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ORC2 origin recognition complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 4999, updated on 7-Jun-2020

Summary

Official Symbol
ORC2provided by HGNC
Official Full Name
origin recognition complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:8488
See related
Ensembl:ENSG00000115942 MIM:601182
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORC2L
Summary
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. [provided by RefSeq, Oct 2010]
Expression
Ubiquitous expression in testis (RPKM 10.9), thyroid (RPKM 5.8) and 25 other tissues See more
Orthologs

Genomic context

See ORC2 in Genome Data Viewer
Location:
2q33.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (200908977..200963701, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (201774894..201828424, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 312, pseudogene Neighboring gene peptidylprolyl isomerase like 3 Neighboring gene NGG1 interacting factor 3 like 1 Neighboring gene RNA, U6 small nuclear 762, pseudogene Neighboring gene uncharacterized LOC105373835 Neighboring gene family with sequence similarity 126 member B Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 35 Neighboring gene ribosomal protein L23a pseudogene 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication TAS
Traceable Author Statement
more info
 
DNA replication initiation TAS
Traceable Author Statement
more info
PubMed 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome inner kinetochore IEA
Inferred from Electronic Annotation
more info
 
heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nuclear chromosome, telomeric region HDA PubMed 
colocalizes_with nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear origin of replication recognition complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
origin recognition complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
origin recognition complex subunit 2
Names
origin recognition complex protein 2 homolog
origin recognition complex, subunit 2 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006190.5NP_006181.1  origin recognition complex subunit 2

    See identical proteins and their annotated locations for NP_006181.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes a functional protein.
    Source sequence(s)
    AC005037, AI033876, DA111542, U40268
    Consensus CDS
    CCDS2334.1
    UniProtKB/Swiss-Prot
    Q13416
    UniProtKB/TrEMBL
    A0A024R411
    Related
    ENSP00000234296.2, ENST00000234296.7
    Conserved Domains (1) summary
    pfam04084
    Location:256562
    ORC2; Origin recognition complex subunit 2

RNA

  1. NR_033915.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) retains an intron in the CDS, resulting in a premature stop codon, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, and is probably not making a functional protein.
    Source sequence(s)
    AC005037, AI033876, AK302614, BP264347, DA545257, U40268

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    200908977..200963701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511252.3XP_011509554.1  origin recognition complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_011509554.1

    Conserved Domains (1) summary
    pfam04084
    Location:276582
    ORC2; Origin recognition complex subunit 2
  2. XM_006712555.4XP_006712618.1  origin recognition complex subunit 2 isoform X2

    See identical proteins and their annotated locations for XP_006712618.1

    UniProtKB/Swiss-Prot
    Q13416
    UniProtKB/TrEMBL
    A0A024R411
    Conserved Domains (1) summary
    pfam04084
    Location:256562
    ORC2; Origin recognition complex subunit 2
  3. XM_011511253.3XP_011509555.1  origin recognition complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_011509555.1

    Conserved Domains (1) summary
    pfam04084
    Location:276582
    ORC2; Origin recognition complex subunit 2

RNA

  1. XR_001738755.2 RNA Sequence

  2. XR_922930.3 RNA Sequence

  3. XR_002959301.1 RNA Sequence

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