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ORC2 origin recognition complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 4999, updated on 3-May-2025
Official Symbol
ORC2provided by HGNC
Official Full Name
origin recognition complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:8488
See related
Ensembl:ENSG00000115942 MIM:601182; AllianceGenome:HGNC:8488
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORC2L
Summary
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. [provided by RefSeq, Oct 2010]
Expression
Ubiquitous expression in testis (RPKM 10.9), thyroid (RPKM 5.8) and 25 other tissues See more
Orthologs
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See ORC2 in Genome Data Viewer
Location:
2q33.1
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (200908977..200963660, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (201392427..201447106, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (201773700..201828383, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:201753436-201754635 Neighboring gene RNA, U6 small nuclear 312, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16968 Neighboring gene peptidylprolyl isomerase like 3 Neighboring gene NGG1 interacting factor 3 like 1 Neighboring gene RNA, U6 small nuclear 762, pseudogene Neighboring gene OCT4 hESC enhancer GRCh37_chr2:201799831-201800332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16969 Neighboring gene uncharacterized LOC105373835 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:201828394-201828792 Neighboring gene hyccin PI4KA lipid kinase complex subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16970 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:201907391-201907902 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:201907903-201908415 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 35 Neighboring gene ribosomal protein L23a pseudogene 30

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA replication origin binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA replication origin binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region HDA PubMed 
colocalizes_with chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in heterochromatin IEA
Inferred from Electronic Annotation
more info
 
part_of inner kinetochore IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear origin of replication recognition complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear origin of replication recognition complex IEA
Inferred from Electronic Annotation
more info
 
part_of nuclear origin of replication recognition complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
part_of origin recognition complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of origin recognition complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
origin recognition complex subunit 2
Names
origin recognition complex protein 2 homolog
origin recognition complex, subunit 2 homolog

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006190.5NP_006181.1  origin recognition complex subunit 2

    See identical proteins and their annotated locations for NP_006181.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes a functional protein.
    Source sequence(s)
    AC005037, AI033876, DA111542, U40268
    Consensus CDS
    CCDS2334.1
    UniProtKB/Swiss-Prot
    Q13204, Q13416, Q53TX5
    UniProtKB/TrEMBL
    B4DYU9
    Related
    ENSP00000234296.2, ENST00000234296.7
    Conserved Domains (1) summary
    pfam04084
    Location:256565
    ORC2; Origin recognition complex subunit 2

RNA

  1. NR_033915.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) retains an intron in the CDS, resulting in a premature stop codon, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, and is probably not making a functional protein.
    Source sequence(s)
    AC005037, AI033876, AK302614, BP264347, DA545257, U40268

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    200908977..200963660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511252.4XP_011509554.1  origin recognition complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_011509554.1

    UniProtKB/TrEMBL
    B4DYU9
    Conserved Domains (1) summary
    pfam04084
    Location:276582
    ORC2; Origin recognition complex subunit 2
  2. XM_006712555.5XP_006712618.1  origin recognition complex subunit 2 isoform X2

    See identical proteins and their annotated locations for XP_006712618.1

    UniProtKB/Swiss-Prot
    Q13204, Q13416, Q53TX5
    UniProtKB/TrEMBL
    B4DYU9
    Conserved Domains (1) summary
    pfam04084
    Location:256565
    ORC2; Origin recognition complex subunit 2
  3. XM_047444569.1XP_047300525.1  origin recognition complex subunit 2 isoform X2

    UniProtKB/Swiss-Prot
    Q13204, Q13416, Q53TX5
    UniProtKB/TrEMBL
    B4DYU9
  4. XM_011511253.4XP_011509555.1  origin recognition complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_011509555.1

    UniProtKB/TrEMBL
    B4DYU9
    Conserved Domains (1) summary
    pfam04084
    Location:276582
    ORC2; Origin recognition complex subunit 2
  5. XM_047444568.1XP_047300524.1  origin recognition complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    B4DYU9
  6. XM_047444572.1XP_047300528.1  origin recognition complex subunit 2 isoform X4

  7. XM_047444570.1XP_047300526.1  origin recognition complex subunit 2 isoform X3

RNA

  1. XR_002959301.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    201392427..201447106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342304.1XP_054198279.1  origin recognition complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    B4DYU9
  2. XM_054342307.1XP_054198282.1  origin recognition complex subunit 2 isoform X2

    UniProtKB/Swiss-Prot
    Q13204, Q13416, Q53TX5
    UniProtKB/TrEMBL
    B4DYU9
  3. XM_054342306.1XP_054198281.1  origin recognition complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    B4DYU9
  4. XM_054342308.1XP_054198283.1  origin recognition complex subunit 2 isoform X2

    UniProtKB/Swiss-Prot
    Q13204, Q13416, Q53TX5
    UniProtKB/TrEMBL
    B4DYU9
  5. XM_054342305.1XP_054198280.1  origin recognition complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    B4DYU9
  6. XM_054342310.1XP_054198285.1  origin recognition complex subunit 2 isoform X4

  7. XM_054342309.1XP_054198284.1  origin recognition complex subunit 2 isoform X3

RNA

  1. XR_008486379.1 RNA Sequence