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ifta-1 Anaphase-promoting complex subunit 4-like WD40 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 183817, updated on 18-Sep-2024

Summary

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Official Symbol
ifta-1
Official Full Name
Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
Primary source
WormBase:WBGene00016935
Locus tag
CELE_C54G7.4
See related
AllianceGenome:WB:WBGene00016935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in chemotaxis; intraciliary transport; and non-motile cilium assembly. Located in axoneme and ciliary basal body. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Ellis-Van Creveld syndrome; cranioectodermal dysplasia 2; and short-rib thoracic dysplasia 7 with or without polydactyly. Orthologous to human WDR35 (WD repeat domain 35). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
27
Sequence:
Chromosome: X; NC_003284.9 (5545587..5552752, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF19 domain-containing protein Neighboring gene ncRNA Neighboring gene SAP30_Sin3_bdg domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional genomics of intraflagellar transport-associated proteins in C. elegans. Inglis PN, et al. Methods Cell Biol, 2009. PMID 20409822
  2. Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Li JB, et al. Cell, 2004 May 14. PMID 15137946
  3. Regulatory Factor X (RFX)-mediated transcriptional rewiring of ciliary genes in animals. Piasecki BP, et al. Proc Natl Acad Sci U S A, 2010 Jul 20. PMID 20615967, Free PMC Article
  4. The WD repeat-containing protein IFTA-1 is required for retrograde intraflagellar transport. Blacque OE, et al. Mol Biol Cell, 2006 Dec. PMID 17021254, Free PMC Article
  5. Dynein-Driven Retrograde Intraflagellar Transport Is Triphasic in C. elegans Sensory Cilia. Yi P, et al. Curr Biol, 2017 May 22. PMID 28479320

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data indicate that IFTA-1 is a novel IFT protein that is required for retrograde transport along ciliary axonemes.
    Title: The WD repeat-containing protein IFTA-1 is required for retrograde intraflagellar transport.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in intraciliary retrograde transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of intraciliary transport particle A IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in non-motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
NP_508940.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5545587..5552752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076539.7 → NP_508940.4  Anaphase-promoting complex subunit 4-like WD40 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508940.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18859
    Conserved Domains (3) summary
    COG2319
    Location:31 → 210
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:38 → 87
    7WD40; WD40 repeat [structural motif]
    pfam12894
    Location:334 → 392
    ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
Nucleotide Protein
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