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TSC22D3 TSC22 domain family member 3 [ Homo sapiens (human) ]

Gene ID: 1831, updated on 2-Oct-2018

Summary

Official Symbol
TSC22D3provided by HGNC
Official Full Name
TSC22 domain family member 3provided by HGNC
Primary source
HGNC:HGNC:3051
See related
Ensembl:ENSG00000157514 MIM:300506; Vega:OTTHUMG00000022168
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIP; GILZ; DSIPI; TSC-22R
Summary
This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in fat (RPKM 114.8), appendix (RPKM 102.3) and 25 other tissues See more
Orthologs

Genomic context

See TSC22D3 in Genome Data Viewer
Location:
Xq22.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (107713221..107777329, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (106956451..107020559, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene FRMPD3 antisense RNA 1 Neighboring gene FERM and PDZ domain containing 3 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 Neighboring gene nuclear cap binding protein subunit 2 like Neighboring gene midline 2 Neighboring gene uncharacterized LOC101928335

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp313A1123

Gene Ontology Provided by GOA

Process Evidence Code Pubs
ion transmembrane transport TAS
Traceable Author Statement
more info
 
negative regulation of activation-induced cell death of T cells IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
response to osmotic stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TSC22 domain family protein 3
Names
DSIP-immunoreactive leucine zipper protein
DSIP-immunoreactive peptide
TSC-22 related protein
TSC-22-like protein
delta sleep-inducing peptide immunoreactor
glucocorticoid-induced leucine zipper protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015881.1NP_001015881.1  TSC22 domain family protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001015881.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus when compared to isoform 1.
    Source sequence(s)
    AB025432, BQ919216, CR933650
    Consensus CDS
    CCDS35365.1
    UniProtKB/Swiss-Prot
    Q99576
    UniProtKB/TrEMBL
    Q5JRJ2
    Related
    ENSP00000361466.4, OTTHUMP00000023811, ENST00000372390.8, OTTHUMT00000057844
    Conserved Domains (1) summary
    pfam01166
    Location:157
    TSC22; TSC-22/dip/bun family
  2. NM_001318468.1NP_001305397.1  TSC22 domain family protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    BX647854, CR933650, DA170687
    Consensus CDS
    CCDS14530.1
    UniProtKB/Swiss-Prot
    Q99576
    Related
    ENSP00000314655.4, OTTHUMP00000217940, ENST00000315660.8, OTTHUMT00000360061
    Conserved Domains (1) summary
    pfam01166
    Location:124180
    TSC22; TSC-22/dip/bun family
  3. NM_001318470.1NP_001305399.1  TSC22 domain family protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AK092645, CR933650, DA170687
    Consensus CDS
    CCDS14530.1
    UniProtKB/Swiss-Prot
    Q99576
    Related
    ENSP00000361459.2, OTTHUMP00000023814, ENST00000372384.6, OTTHUMT00000057847
    Conserved Domains (1) summary
    pfam01166
    Location:124180
    TSC22; TSC-22/dip/bun family
  4. NM_004089.3NP_004080.2  TSC22 domain family protein 3 isoform 2

    See identical proteins and their annotated locations for NP_004080.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a different 5' end exon compared to transcript variant 1, resulting in an isoform (2) with a different and a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AB025432, AL110191, CR933650
    Consensus CDS
    CCDS14531.1
    UniProtKB/Swiss-Prot
    Q99576
    Related
    ENSP00000361474.2, OTTHUMP00000023810, ENST00000372397.6, OTTHUMT00000057843
    Conserved Domains (1) summary
    pfam01166
    Location:58114
    TSC22; TSC-22/dip/bun family
  5. NM_198057.2NP_932174.1  TSC22 domain family protein 3 isoform 1

    See identical proteins and their annotated locations for NP_932174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AK092669, BM047061, CR933650
    Consensus CDS
    CCDS14530.1
    UniProtKB/Swiss-Prot
    Q99576
    Related
    ENSP00000361458.4, OTTHUMP00000023813, ENST00000372383.8, OTTHUMT00000057846
    Conserved Domains (1) summary
    pfam01166
    Location:124180
    TSC22; TSC-22/dip/bun family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    107713221..107777329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262099.1XP_005262156.1  TSC22 domain family protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005262156.1

    UniProtKB/Swiss-Prot
    Q99576
    Conserved Domains (1) summary
    pfam01166
    Location:124180
    TSC22; TSC-22/dip/bun family
  2. XM_011530884.1XP_011529186.1  TSC22 domain family protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011529186.1

    UniProtKB/Swiss-Prot
    Q99576
    Conserved Domains (1) summary
    pfam01166
    Location:124180
    TSC22; TSC-22/dip/bun family
  3. XM_005262103.4XP_005262160.1  TSC22 domain family protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005262160.1

    UniProtKB/Swiss-Prot
    Q99576
    Conserved Domains (1) summary
    pfam01166
    Location:124180
    TSC22; TSC-22/dip/bun family
  4. XM_005262102.1XP_005262159.1  TSC22 domain family protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005262159.1

    UniProtKB/Swiss-Prot
    Q99576
    Conserved Domains (1) summary
    pfam01166
    Location:124180
    TSC22; TSC-22/dip/bun family
  5. XM_005262100.1XP_005262157.1  TSC22 domain family protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005262157.1

    UniProtKB/Swiss-Prot
    Q99576
    Related
    ENSP00000427427.1, OTTHUMP00000217951, ENST00000506081.5, OTTHUMT00000057849
    Conserved Domains (1) summary
    pfam01166
    Location:124180
    TSC22; TSC-22/dip/bun family
  6. XM_017029335.1XP_016884824.1  TSC22 domain family protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q99576
    Conserved Domains (1) summary
    pfam01166
    Location:124180
    TSC22; TSC-22/dip/bun family
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