U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TSC22D3 TSC22 domain family member 3 [ Homo sapiens (human) ]

Gene ID: 1831, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
TSC22D3provided by HGNC
Official Full Name
TSC22 domain family member 3provided by HGNC
Primary source
HGNC:HGNC:3051
See related
Ensembl:ENSG00000157514 MIM:300506; AllianceGenome:HGNC:3051
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIP; GILZ; DSIPI; TSC-22R
Summary
This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in fat (RPKM 114.8), appendix (RPKM 102.3) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TSC22D3 in Genome Data Viewer
Location:
Xq22.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (107713221..107775988, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (106149979..106212727, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (106956451..107019218, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 3 Neighboring gene FRMPD3 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:106804525-106805322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:106806121-106806916 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:106806917-106807714 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:106842109-106842610 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:106842611-106843110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:106843233-106843778 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:106843779-106844324 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20928 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:106876457-106876559 Neighboring gene Sharpr-MPRA regulatory region 15331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29833 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20931 Neighboring gene NANOG hESC enhancer GRCh37_chrX:106943730-106944231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29835 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:106968611-106969112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:106975096-106975705 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:106980023-106980600 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:106992672-106993524 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:106993525-106994376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:107017786-107018363 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:107018364-107018940 Neighboring gene Sharpr-MPRA regulatory region 6089 Neighboring gene nuclear cap binding protein subunit 2 like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20933 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20934 Neighboring gene Sharpr-MPRA regulatory region 15158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:107120928-107121436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:107121437-107121945 Neighboring gene midline 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29837 Neighboring gene uncharacterized LOC101928335 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:107162128-107162628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:107162629-107163129

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Role of GILZ in immune regulation, glucocorticoid actions and rheumatoid arthritis. Beaulieu E, et al. Nat Rev Rheumatol, 2011 Jun. PMID 21556028
  2. Recombinant long-glucocorticoid-induced leucine zipper (L-GILZ) protein restores the control of proliferation in gilz KO spermatogonia. Venanzi A, et al. Eur J Pharm Sci, 2014 Oct 15. PMID 24993177
  3. Downregulation of the glucocorticoid-induced leucine zipper (GILZ) promotes vascular inflammation. Hahn RT, et al. Atherosclerosis, 2014 Jun. PMID 24747114
  4. Activation of GILZ gene by photoactivated 8-methoxypsoralen: potential role of immunoregulatory dendritic cells in extracorporeal photochemotherapy. Futterleib JS, et al. Transfus Apher Sci, 2014 Jun. PMID 24215840, Free PMC Article
  5. GILZ overexpression inhibits endothelial cell adhesive function through regulation of NF-κB and MAPK activity. Cheng Q, et al. J Immunol, 2013 Jul 1. PMID 23729444

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Type 1 interferon suppresses expression and glucocorticoid induction of glucocorticoid-induced leucine zipper (GILZ).
    Title: Type 1 interferon suppresses expression and glucocorticoid induction of glucocorticoid-induced leucine zipper (GILZ).
  2. Expression Profiles of GILZ and Annexin A1 in Human Oral Candidiasis and Lichen Planus.
    Title: Expression Profiles of GILZ and Annexin A1 in Human Oral Candidiasis and Lichen Planus.
  3. Glucocorticoid-induced leucine zipper regulates liver fibrosis by suppressing CCL2-mediated leukocyte recruitment.
    Title: Glucocorticoid-induced leucine zipper regulates liver fibrosis by suppressing CCL2-mediated leukocyte recruitment.
  4. Glucocorticoid-transactivated TSC22D3 attenuates hypoxia- and diabetes-induced Muller glial galectin-1 expression via HIF-1alpha destabilization.
    Title: Glucocorticoid-transactivated TSC22D3 attenuates hypoxia- and diabetes-induced Müller glial galectin-1 expression via HIF-1α destabilization.
  5. MiR-222-3p ameliorates glucocorticoid-induced inhibition of airway epithelial cell repair through down-regulating GILZ expression.
    Title: MiR-222-3p ameliorates glucocorticoid-induced inhibition of airway epithelial cell repair through down-regulating GILZ expression.
  6. Short-Chain Alcohols Upregulate GILZ Gene Expression and Attenuate LPS-Induced Septic Immune Response.
    Title: Short-Chain Alcohols Upregulate GILZ Gene Expression and Attenuate LPS-Induced Septic Immune Response.
  7. Glucocorticoids and Glucocorticoid-Induced-Leucine-Zipper (GILZ) in Psoriasis.
    Title: Glucocorticoids and Glucocorticoid-Induced-Leucine-Zipper (GILZ) in Psoriasis.
  8. Implicating the Role of GILZ in Glucocorticoid Modulation of T-Cell Activation.
    Title: Implicating the Role of GILZ in Glucocorticoid Modulation of T-Cell Activation.
  9. Dramatic alterations in GILZ occur in those exposed to a stressor in early life, adulthood or both.
    Title: Glucocorticoid-induced leucine zipper "quantifies" stressors and increases male susceptibility to PTSD.
  10. L-GILZ regulates thyroid cancer cell proliferation.
    Title: Long glucocorticoid-induced leucine zipper regulates human thyroid cancer cell proliferation.
Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • DKFZp313A1123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of activation-induced cell death of T cells IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in response to osmotic stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
TSC22 domain family protein 3
Names
DSIP-immunoreactive leucine zipper protein
DSIP-immunoreactive peptide
TSC-22 related protein
TSC-22-like protein
delta sleep-inducing peptide immunoreactor
glucocorticoid-induced leucine zipper protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015881.2 → NP_001015881.1  TSC22 domain family protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001015881.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus when compared to isoform 1.
    Source sequence(s)
    AB025432, AL590423, BQ919216, CR933650
    Consensus CDS
    CCDS35365.1
    UniProtKB/TrEMBL
    B2R4H9
    Related
    ENSP00000361466.4, ENST00000372390.8
    Conserved Domains (1) summary
    pfam01166
    Location:1 → 57
    TSC22; TSC-22/dip/bun family

  2. NM_001318468.1 → NP_001305397.1  TSC22 domain family protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    BX647854, CR933650, DA170687
    Consensus CDS
    CCDS14530.1
    UniProtKB/TrEMBL
    B4DU81
    Related
    ENSP00000314655.4, ENST00000315660.8
    Conserved Domains (1) summary
    pfam01166
    Location:124 → 180
    TSC22; TSC-22/dip/bun family

  3. NM_001318470.1 → NP_001305399.1  TSC22 domain family protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AK092645, CR933650, DA170687
    Consensus CDS
    CCDS14530.1
    UniProtKB/TrEMBL
    B4DU81
    Related
    ENSP00000361459.2, ENST00000372384.6
    Conserved Domains (1) summary
    pfam01166
    Location:124 → 180
    TSC22; TSC-22/dip/bun family

  4. NM_004089.4 → NP_004080.2  TSC22 domain family protein 3 isoform 2

    See identical proteins and their annotated locations for NP_004080.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a different 5' end exon compared to transcript variant 1, resulting in an isoform (2) with a different and a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AB025432, AL110191, AL590423, CR933650
    Consensus CDS
    CCDS14531.1
    UniProtKB/Swiss-Prot
    Q5H9S3, Q5JRI9, Q5JRJ2, Q6FIH6, Q8NAI1, Q8WVB9, Q99576, Q9UBN5, Q9UG13
    UniProtKB/TrEMBL
    B3KXT7
    Related
    ENSP00000361474.2, ENST00000372397.6
    Conserved Domains (1) summary
    cd21940
    Location:57 → 134
    ZIP_TSC22D3; leucine zipper domain found in TSC22 domain family protein 3

  5. NM_198057.3 → NP_932174.1  TSC22 domain family protein 3 isoform 1

    See identical proteins and their annotated locations for NP_932174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AK092669, BM047061, CR933650
    Consensus CDS
    CCDS14530.1
    UniProtKB/TrEMBL
    B4DU81
    Related
    ENSP00000361458.4, ENST00000372383.9
    Conserved Domains (1) summary
    pfam01166
    Location:124 → 180
    TSC22; TSC-22/dip/bun family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    107713221..107775988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    106149979..106212727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99576.2 GenPept UniProtKB/Swiss-Prot:Q99576

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous