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Tsc22d3 TSC22 domain family, member 3 [ Mus musculus (house mouse) ]

Gene ID: 14605, updated on 20-Feb-2024

Summary

Official Symbol
Tsc22d3provided by MGI
Official Full Name
TSC22 domain family, member 3provided by MGI
Primary source
MGI:MGI:1196284
See related
Ensembl:ENSMUSG00000031431 AllianceGenome:MGI:1196284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DIP; Gilz; Dsip1; Tilz3; TSC-22R
Summary
Enables MRF binding activity. Acts upstream of or within several processes, including negative regulation of activation-induced cell death of T cells; negative regulation of skeletal muscle tissue development; and negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including early conceptus; genitourinary system; nervous system; sensory organ; and viscerocranium. Orthologous to human TSC22D3 (TSC22 domain family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 50.5), lung adult (RPKM 48.1) and 25 other tissues See more
Orthologs
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Genomic context

See Tsc22d3 in Genome Data Viewer
Location:
X F1; X 61.35 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (139440277..139501257, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (140539528..140600522, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chrX:136990945-136991245 Neighboring gene STARR-seq mESC enhancer starr_48006 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 Neighboring gene STARR-positive B cell enhancer mm9_chrX:137038534-137038835 Neighboring gene predicted gene, 39538 Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene Neighboring gene midline 2 Neighboring gene predicted gene, 23199

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
TSC22 domain family protein 3
Names
TSC22-related inducible leucine zipper 3
delta sleep inducing peptide, immunoreactor
glucocorticoid-induced leucine zipper protein
long glucocorticoid-induced leucine zipper protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077364.2NP_001070832.1  TSC22 domain family protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001070832.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL683809
    Consensus CDS
    CCDS41150.1
    UniProtKB/Swiss-Prot
    Q9Z2S7
    Related
    ENSMUSP00000108620.3, ENSMUST00000112996.9
    Conserved Domains (1) summary
    pfam01166
    Location:122178
    TSC22; TSC-22/dip/bun family
  2. NM_010286.6NP_034416.3  TSC22 domain family protein 3 isoform 2

    See identical proteins and their annotated locations for NP_034416.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different 5' structure, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL683809
    Consensus CDS
    CCDS30440.1
    UniProtKB/Swiss-Prot
    B1AVF3, C6EX03, Q3UNI6, Q8K160, Q9EQN0, Q9EQN1, Q9EQN2, Q9Z2S7
    Conserved Domains (1) summary
    cd21940
    Location:57137
    ZIP_TSC22D3; leucine zipper domain found in TSC22 domain family protein 3

RNA

  1. NR_122039.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a different 5' structure compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL683809
    Related
    ENSMUST00000112995.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    139440277..139501257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528504.4XP_006528567.1  TSC22 domain family protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006528567.1

    UniProtKB/Swiss-Prot
    Q9Z2S7
    Conserved Domains (1) summary
    pfam01166
    Location:122178
    TSC22; TSC-22/dip/bun family
  2. XM_006528499.5XP_006528562.1  TSC22 domain family protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006528562.1

    UniProtKB/Swiss-Prot
    Q9Z2S7
    Conserved Domains (1) summary
    pfam01166
    Location:122178
    TSC22; TSC-22/dip/bun family
  3. XM_006528500.4XP_006528563.1  TSC22 domain family protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006528563.1

    UniProtKB/Swiss-Prot
    Q9Z2S7
    Conserved Domains (1) summary
    pfam01166
    Location:122178
    TSC22; TSC-22/dip/bun family
  4. XM_006528505.5XP_006528568.1  TSC22 domain family protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006528568.1

    UniProtKB/Swiss-Prot
    Q9Z2S7
    Conserved Domains (1) summary
    pfam01166
    Location:122178
    TSC22; TSC-22/dip/bun family
  5. XM_036161820.1XP_036017713.1  TSC22 domain family protein 3 isoform X2

    UniProtKB/Swiss-Prot
    B1AVF3, C6EX03, Q3UNI6, Q8K160, Q9EQN0, Q9EQN1, Q9EQN2, Q9Z2S7
    Related
    ENSMUSP00000062589.5, ENSMUST00000055738.12
    Conserved Domains (1) summary
    cd21940
    Location:57137
    ZIP_TSC22D3; leucine zipper domain found in TSC22 domain family protein 3
  6. XM_006528503.4XP_006528566.1  TSC22 domain family protein 3 isoform X3

    See identical proteins and their annotated locations for XP_006528566.1

    UniProtKB/Swiss-Prot
    Q9Z2S7
    Conserved Domains (1) summary
    pfam01166
    Location:157
    TSC22; TSC-22/dip/bun family