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ARID3A AT-rich interaction domain 3A [ Homo sapiens (human) ]

Gene ID: 1820, updated on 21-Dec-2019

Summary

Official Symbol
ARID3Aprovided by HGNC
Official Full Name
AT-rich interaction domain 3Aprovided by HGNC
Primary source
HGNC:HGNC:3031
See related
Ensembl:ENSG00000116017 MIM:603265
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRIL1; DRIL3; BRIGHT; E2FBP1
Summary
This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 13.1), bone marrow (RPKM 2.3) and 16 other tissues See more
Orthologs

Genomic context

See ARID3A in Genome Data Viewer
Location:
19p13.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (925733..975939)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (925733..972816)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene R3H domain containing 4 Neighboring gene KISS1 receptor Neighboring gene HNF4 motif-containing MPRA enhancer 174 Neighboring gene WD repeat domain 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
AT-rich interactive domain-containing protein 3A
Names
ARID domain-containing 3A
ARID domain-containing protein 3A
AT rich interactive domain 3A (BRIGHT- like) protein
AT rich interactive domain 3A (BRIGHT-like)
B-cell regulator of IgH transcription
E2F-binding protein 1
dead ringer-like 1
dead ringer-like protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005224.3NP_005215.1  AT-rich interactive domain-containing protein 3A

    See identical proteins and their annotated locations for NP_005215.1

    Status: REVIEWED

    Source sequence(s)
    AC005379, AC005391, BC060828, U88047
    Consensus CDS
    CCDS12050.1
    UniProtKB/Swiss-Prot
    Q99856
    Related
    ENSP00000263620.2, ENST00000263620.8
    Conserved Domains (1) summary
    smart00501
    Location:239331
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    925733..975939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026445.1XP_016881934.1  AT-rich interactive domain-containing protein 3A isoform X1

    UniProtKB/Swiss-Prot
    Q99856
    Conserved Domains (1) summary
    smart00501
    Location:239331
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
  2. XM_024451407.1XP_024307175.1  AT-rich interactive domain-containing protein 3A isoform X2

    Conserved Domains (1) summary
    smart00501
    Location:180
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
  3. XM_005259514.4XP_005259571.1  AT-rich interactive domain-containing protein 3A isoform X1

    See identical proteins and their annotated locations for XP_005259571.1

    UniProtKB/Swiss-Prot
    Q99856
    Conserved Domains (1) summary
    smart00501
    Location:239331
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
  4. XM_005259513.5XP_005259570.1  AT-rich interactive domain-containing protein 3A isoform X1

    See identical proteins and their annotated locations for XP_005259570.1

    UniProtKB/Swiss-Prot
    Q99856
    Conserved Domains (1) summary
    smart00501
    Location:239331
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
  5. XM_017026446.1XP_016881935.1  AT-rich interactive domain-containing protein 3A isoform X2

    Conserved Domains (1) summary
    smart00501
    Location:180
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
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