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Arid3a AT rich interactive domain 3A (BRIGHT-like) [ Mus musculus (house mouse) ]

Gene ID: 13496, updated on 5-Jan-2023

Summary

Official Symbol
Arid3aprovided by MGI
Official Full Name
AT rich interactive domain 3A (BRIGHT-like)provided by MGI
Primary source
MGI:MGI:1328360
See related
Ensembl:ENSMUSG00000019564 AllianceGenome:MGI:1328360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dri1; Dril1; Bright
Summary
Enables several functions, including chromatin binding activity; identical protein binding activity; and transcription coregulator activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and skin. Orthologous to human ARID3A (AT-rich interaction domain 3A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 13.2), testis adult (RPKM 6.1) and 25 other tissues See more
Orthologs
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Genomic context

See Arid3a in Genome Data Viewer
Location:
10; 10 C1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79762877..79790852)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79927043..79955018)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene KISS1 receptor Neighboring gene predicted gene, 40715 Neighboring gene WD repeat domain 18 Neighboring gene glutamate receptor, ionotropic, NMDA3B Neighboring gene transmembrane protein 259

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
AT-rich interactive domain-containing protein 3A
Names
ARID domain-containing protein 3A
AT rich interactive domain 3A (Bright like)
B-cell regulator of IgH transcription
dead ringer homolog 1
dead ringer-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288625.1NP_001275554.1  AT-rich interactive domain-containing protein 3A isoform a

    See identical proteins and their annotated locations for NP_001275554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK141283, BP763961
    Consensus CDS
    CCDS23999.1
    UniProtKB/Swiss-Prot
    Q62431, Q80YP8
    Related
    ENSMUSP00000101015.2, ENSMUST00000105376.2
    Conserved Domains (1) summary
    cd16878
    Location:224356
    ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins
  2. NM_001288626.1NP_001275555.1  AT-rich interactive domain-containing protein 3A isoform b

    See identical proteins and their annotated locations for NP_001275555.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 2 aa shorter compared to isoform a.
    Source sequence(s)
    BC050925, BP763961, BY126533
    Consensus CDS
    CCDS78851.1
    UniProtKB/Swiss-Prot
    Q62431
    UniProtKB/TrEMBL
    A0A0R4J1A7
    Related
    ENSMUSP00000101016.2, ENSMUST00000105377.8
    Conserved Domains (1) summary
    smart00501
    Location:244336
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
  3. NM_007880.4NP_031906.1  AT-rich interactive domain-containing protein 3A isoform a

    See identical proteins and their annotated locations for NP_031906.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK141283, BC050925, BP763961, BY126533
    Consensus CDS
    CCDS23999.1
    UniProtKB/Swiss-Prot
    Q62431, Q80YP8
    Related
    ENSMUSP00000019708.6, ENSMUST00000019708.12
    Conserved Domains (1) summary
    cd16878
    Location:224356
    ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79762877..79790852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513202.5XP_006513265.1  AT-rich interactive domain-containing protein 3A isoform X1

    See identical proteins and their annotated locations for XP_006513265.1

    UniProtKB/Swiss-Prot
    Q62431, Q80YP8
    Conserved Domains (1) summary
    cd16878
    Location:224356
    ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins
  2. XM_006513201.5XP_006513264.1  AT-rich interactive domain-containing protein 3A isoform X1

    See identical proteins and their annotated locations for XP_006513264.1

    UniProtKB/Swiss-Prot
    Q62431, Q80YP8
    Conserved Domains (1) summary
    cd16878
    Location:224356
    ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins