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DRG2 developmentally regulated GTP binding protein 2 [ Homo sapiens (human) ]

Gene ID: 1819, updated on 5-Aug-2018

Summary

Official Symbol
DRG2provided by HGNC
Official Full Name
developmentally regulated GTP binding protein 2provided by HGNC
Primary source
HGNC:HGNC:3030
See related
Ensembl:ENSG00000108591 MIM:602986; Vega:OTTHUMG00000059399
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in ovary (RPKM 11.9), prostate (RPKM 10.9) and 25 other tissues See more
Orthologs

Genomic context

See DRG2 in Genome Data Viewer
Location:
17p11.2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (18087867..18107985)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17991181..18011299)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene dynein regulatory complex subunit 3 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2 Neighboring gene GID complex subunit 4 homolog Neighboring gene uncharacterized LOC105371566 Neighboring gene myosin XVA Neighboring gene uncharacterized LOC105371567 Neighboring gene alkB homolog 5, RNA demethylase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
developmentally-regulated GTP-binding protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330144.1NP_001317073.1  developmentally-regulated GTP-binding protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC087164, AI478627
    Consensus CDS
    CCDS82082.1
    UniProtKB/TrEMBL
    A8MZF9
    Related
    ENSP00000379076.4, ENST00000395726.8
    Conserved Domains (4) summary
    cd01896
    Location:63295
    DRG; Developmentally Regulated GTP-binding protein (DRG)
    COG1163
    Location:1331
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
    cl00155
    Location:289331
    UBQ; Ubiquitin-like proteins
    cl21455
    Location:3119
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001388.4NP_001379.1  developmentally-regulated GTP-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001379.1

    Status: REVIEWED

    Source sequence(s)
    AI478627, BC000493, DA602486, DC298961, X80754
    Consensus CDS
    CCDS11191.1
    UniProtKB/Swiss-Prot
    P55039
    Related
    ENSP00000225729.3, OTTHUMP00000065704, ENST00000225729.7, OTTHUMT00000132075
    Conserved Domains (4) summary
    cd01666
    Location:289363
    TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
    cd01896
    Location:63295
    DRG; Developmentally Regulated GTP-binding protein (DRG)
    COG1163
    Location:1364
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
    cl21455
    Location:3119
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    18087867..18107985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256500.2XP_005256557.1  developmentally-regulated GTP-binding protein 2 isoform X3

    Conserved Domains (2) summary
    cd01666
    Location:208303
    TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
    cd01896
    Location:1214
    DRG; Developmentally Regulated GTP-binding protein (DRG)
  2. XM_011523707.1XP_011522009.1  developmentally-regulated GTP-binding protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011522009.1

    Conserved Domains (2) summary
    cd01666
    Location:145240
    TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
    cd01896
    Location:1151
    DRG; Developmentally Regulated GTP-binding protein (DRG)
  3. XM_017024297.1XP_016879786.1  developmentally-regulated GTP-binding protein 2 isoform X5

  4. XM_005256499.3XP_005256556.1  developmentally-regulated GTP-binding protein 2 isoform X1

    Conserved Domains (4) summary
    cd01666
    Location:289384
    TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
    cd01896
    Location:63295
    DRG; Developmentally Regulated GTP-binding protein (DRG)
    COG1163
    Location:1385
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
    cl21455
    Location:3119
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_011523704.2XP_011522006.1  developmentally-regulated GTP-binding protein 2 isoform X2

    Conserved Domains (4) summary
    cd01896
    Location:63295
    DRG; Developmentally Regulated GTP-binding protein (DRG)
    COG1163
    Location:1352
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
    cl00155
    Location:289352
    UBQ; Ubiquitin-like proteins
    cl21455
    Location:3119
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_011523706.2XP_011522008.1  developmentally-regulated GTP-binding protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011522008.1

    Conserved Domains (2) summary
    cd01666
    Location:145240
    TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
    cd01896
    Location:1151
    DRG; Developmentally Regulated GTP-binding protein (DRG)
  7. XM_017024296.2XP_016879785.1  developmentally-regulated GTP-binding protein 2 isoform X5

RNA

  1. XR_002957980.1 RNA Sequence

    Related
    ENST00000467099.6
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