Drg2 developmentally regulated GTP binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Drg2provided by MGI
Official Full Name: developmentally regulated GTP binding protein 2provided by MGI
Primary source: MGI:MGI:1342307
See related: Ensembl:ENSMUSG00000020537 AllianceGenome:MGI:1342307
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DRG-2
Summary: Predicted to enable GTP binding activity; GTPase activity; and RNA binding activity. Predicted to be involved in cytoplasmic translation. Located in mitochondrion. Is expressed in pituitary gland. Orthologous to human DRG2 (developmentally regulated GTP binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 26.9), ovary adult (RPKM 25.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B2; 11 37.81 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (60345442..60359589)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (60454587..60468754)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DRG2 in macrophages is crucial for initial inflammatory response and protection against Listeria monocytogenes infection.
Title: DRG2 in macrophages is crucial for initial inflammatory response and protection against Listeria monocytogenes infection.
DRG2 knockout (KO) mice displayed defects in motor function in motor coordination and rotarod tests and increased anxiety.
Title: DRG2 Deficient Mice Exhibit Impaired Motor Behaviors with Reduced Striatal Dopamine Release.
Our results reveal a novel mechanism for regulation of membrane tubule stability mediated by DRG2.
Title: Developmentally regulated GTP-binding protein 2 is required for stabilization of Rac1-positive membrane tubules.
Developmentally regulated GTP-binding protein 2 ameliorates EAE by suppressing the development of TH17 cells.
Title: Developmentally regulated GTP-binding protein 2 ameliorates EAE by suppressing the development of TH17 cells.
DRG2 is associated with survival and cytoskeleton organization of osteoclasts under influence of macrophage colony-stimulating factor, and its overexpression leads to elevated bone resorptive activity of osteoclasts, resulting in bone loss.
Title: Overexpression of developmentally regulated GTP-binding protein-2 increases bone loss.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129963 (e-PCR)
- UniSTS:213251

AI255295 (e-PCR)
- UniSTS:160100

RH140016 (e-PCR)
- UniSTS:222098

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: developmentally-regulated GTP-binding protein 2

Names: TRAFAC GTPase DRG2; translation factor GTPase DRG2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021354.3 → NP_067329.1 developmentally-regulated GTP-binding protein 2

See identical proteins and their annotated locations for NP_067329.1

Status: VALIDATED

Source sequence(s)

AL596090

Consensus CDS

CCDS24791.1

UniProtKB/Swiss-Prot

Q5SX94, Q9QXB9

Related

ENSMUSP00000018568.4, ENSMUST00000018568.4

Conserved Domains (1) summary

COG1163
Location:1 → 364

Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]