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Npy5r neuropeptide Y receptor Y5 [ Mus musculus (house mouse) ]

Gene ID: 18168, updated on 9-Mar-2023

Summary

Official Symbol
Npy5rprovided by MGI
Official Full Name
neuropeptide Y receptor Y5provided by MGI
Primary source
MGI:MGI:108082
See related
Ensembl:ENSMUSG00000044014 AllianceGenome:MGI:108082
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Y5R; NPY5-R; NPYY5-R
Summary
Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Acts upstream of or within chemical synaptic transmission. Located in membrane and neuron projection. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (neuropeptide Y receptor Y5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 1.1), frontal lobe adult (RPKM 1.0) and 5 other tissues See more
Orthologs
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Genomic context

See Npy5r in Genome Data Viewer
Location:
8 B3.1; 8 33.15 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (67132617..67140746, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (66679965..66688094, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene translation machinery associated 16 Neighboring gene transketolase-like 2 Neighboring gene neuropeptide Y receptor Y1 Neighboring gene RNA binding motif protein 7 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC151353, MGC151355

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables neuropeptide Y receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables neuropeptide Y receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pancreatic polypeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pancreatic polypeptide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pancreatic polypeptide receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide YY receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide YY receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide YY receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cardiac left ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in generation of ovulation cycle rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of acute inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glutamate secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic signaling via neuropeptide EXP
Inferred from Experiment
more info
PubMed 
involved_in synaptic signaling via neuropeptide IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neuropeptide Y receptor type 5
Names
NPY-Y5 receptor
Y5 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358957.1NP_001345886.1  neuropeptide Y receptor type 5

    Status: VALIDATED

    Source sequence(s)
    AC100541
    Consensus CDS
    CCDS22335.1
    UniProtKB/Swiss-Prot
    Q9JMK1
    UniProtKB/TrEMBL
    A0A8C6N5M2, Q543U8
    Conserved Domains (1) summary
    cd15398
    Location:63456
    7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001358958.1NP_001345887.1  neuropeptide Y receptor type 5

    Status: VALIDATED

    Source sequence(s)
    AC100541
    Consensus CDS
    CCDS22335.1
    UniProtKB/Swiss-Prot
    Q9JMK1
    UniProtKB/TrEMBL
    A0A8C6N5M2, Q543U8
    Related
    ENSMUSP00000148589.2, ENSMUST00000212563.2
    Conserved Domains (1) summary
    cd15398
    Location:63456
    7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_016708.3NP_057917.2  neuropeptide Y receptor type 5

    See identical proteins and their annotated locations for NP_057917.2

    Status: VALIDATED

    Source sequence(s)
    AK045587, BB346009, BB868845, BY008559, BY655564
    Consensus CDS
    CCDS22335.1
    UniProtKB/Swiss-Prot
    O70342, Q9JMK1
    UniProtKB/TrEMBL
    A0A8C6N5M2, Q543U8
    Related
    ENSMUSP00000065157.8, ENSMUST00000070810.8
    Conserved Domains (1) summary
    cd15398
    Location:63456
    7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    67132617..67140746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153813.1XP_036009706.1  neuropeptide Y receptor type 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9JMK1
    UniProtKB/TrEMBL
    A0A8C6N5M2, Q543U8
    Conserved Domains (1) summary
    cd15398
    Location:63456
    7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors