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NPY5R neuropeptide Y receptor Y5 [ Homo sapiens (human) ]

Gene ID: 4889, updated on 5-Jul-2025
Official Symbol
NPY5Rprovided by HGNC
Official Full Name
neuropeptide Y receptor Y5provided by HGNC
Primary source
HGNC:HGNC:7958
See related
Ensembl:ENSG00000164129 MIM:602001; AllianceGenome:HGNC:7958
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPYR5; NPY5-R; NPYY5-R
Summary
The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
Expression
Biased expression in spleen (RPKM 1.2), fat (RPKM 1.1) and 9 other tissues See more
Orthologs
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See NPY5R in Genome Data Viewer
Location:
4q32.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (163343892..163352403)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (166691703..166700212)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (164265044..164273086)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377517 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75696 Neighboring gene mitochondrial ribosomal protein S5 pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:164238175-164238759 Neighboring gene neuropeptide Y receptor Y1 Neighboring gene ribosomal protein L35a pseudogene 12 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:164336685-164337439 Neighboring gene transketolase like 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Functional characterization of human neuropeptide Y receptor subtype five specific antagonists using a luciferase reporter gene assay. Beauverger P, et al. Cell Signal, 2005 Apr. PMID 15601626
  2. Adipose Y5R mRNA is higher in obese than non-obese humans and is correlated with obesity parameters. Chatree S, et al. Exp Biol Med (Maywood), 2018 May. PMID 29763369, Free PMC Article
  3. Neuropeptide Y receptor Y5 as an inducible pro-survival factor in neuroblastoma: implications for tumor chemoresistance. Czarnecka M, et al. Oncogene, 2015 Jun 11. PMID 25132261, Free PMC Article
  4. Molecular identification of the long isoform of the human neuropeptide Y Y5 receptor and pharmacological comparison with the short Y5 receptor isoform. Rodriguez M, et al. Biochem J, 2003 Feb 1. PMID 12398768, Free PMC Article
  5. Conservation of expression of neuropeptide Y5 receptor between human and rat hypothalamus and limbic regions suggests an integral role in central neuroendocrine control. Nichol KA, et al. J Neurosci, 1999 Dec 1. PMID 10575027, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuropeptide Y promotes hepatic apolipoprotein A1 synthesis and secretion through neuropeptide Y Y5 receptor.
    Title: Neuropeptide Y promotes hepatic apolipoprotein A1 synthesis and secretion through neuropeptide Y Y5 receptor.
  2. Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation.
    Title: Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation.
  3. Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.
    Title: Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.
  4. Y1R and Y5R might be the dominant receptors that mediate the effect of NPY-induced fat accumulation in both subcutaneous and visceral adipose tissues. Y1R and Y5R in visceral adipose tissue might be targets of drug development in prevention or treatment of obesity.
    Title: Adipose Y5R mRNA is higher in obese than non-obese humans and is correlated with obesity parameters.
  5. NPY5R is an inducible pro-survival factor that is responsible for chemoresistance in neuroblastoma cells.
    Title: Neuropeptide Y receptor Y5 as an inducible pro-survival factor in neuroblastoma: implications for tumor chemoresistance.
  6. Variations in genes AGRP, CPE, GHRL, GLP1R, HTR2A, NPY1R, NPY5R, SOCS3 and STAT3 showed modest associations with BMI in European Americans.
    Title: Genetic association analysis of 30 genes related to obesity in a European American population.
  7. these data highlight a novel mechanism by which NPY may promote breast cancer progression, and further implicate a pathological role of the NPY Y5R.
    Title: Neuropeptide Y Y5-receptor activation on breast cancer cells acts as a paracrine system that stimulates VEGF expression and secretion to promote angiogenesis.
  8. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT.
  9. Together, our results suggest that Y5R plays an important role in cancer cell growth and migration and could be a novel therapeutic target for breast cancer.
    Title: Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line.
  10. NPY1R and NPY5R have roles in nutrient-specific food intake in Europeans
    Title: Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide Y receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pancreatic polypeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pancreatic polypeptide receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide YY receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide YY receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in cardiac left ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in eating behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in generation of ovulation cycle rhythm IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of acute inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of glutamate secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of acute inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic signaling via neuropeptide IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in presynapse IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
neuropeptide Y receptor type 5
Names
NPY-Y5 receptor
Y5 receptor

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317091.2 → NP_001304020.1  neuropeptide Y receptor type 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    BC034224
    Consensus CDS
    CCDS3804.1
    UniProtKB/Swiss-Prot
    Q15761, Q6GTR7, Q92916
    Related
    ENSP00000423917.1, ENST00000515560.1
    Conserved Domains (1) summary
    cd15398
    Location:42 → 436
    7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001317092.2 → NP_001304021.1  neuropeptide Y receptor type 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    BC042416, HY025097
    Consensus CDS
    CCDS3804.1
    UniProtKB/Swiss-Prot
    Q15761, Q6GTR7, Q92916
    Conserved Domains (1) summary
    cd15398
    Location:42 → 436
    7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_006174.4 → NP_006165.1  neuropeptide Y receptor type 5

    See identical proteins and their annotated locations for NP_006165.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    BC042416, BI464162
    Consensus CDS
    CCDS3804.1
    UniProtKB/Swiss-Prot
    Q15761, Q6GTR7, Q92916
    Related
    ENSP00000339377.3, ENST00000338566.8
    Conserved Domains (1) summary
    cd15398
    Location:42 → 436
    7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    163343892..163352403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532017.3 → XP_011530319.1  neuropeptide Y receptor type 5 isoform X2

    See identical proteins and their annotated locations for XP_011530319.1

    UniProtKB/Swiss-Prot
    Q15761, Q6GTR7, Q92916
    Conserved Domains (1) summary
    cd15398
    Location:42 → 436
    7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_005263038.4 → XP_005263095.1  neuropeptide Y receptor type 5 isoform X2

    See identical proteins and their annotated locations for XP_005263095.1

    UniProtKB/Swiss-Prot
    Q15761, Q6GTR7, Q92916
    Conserved Domains (1) summary
    cd15398
    Location:42 → 436
    7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_017008256.2 → XP_016863745.1  neuropeptide Y receptor type 5 isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:65 → 432
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56 → 178
    7tm_4; Olfactory receptor

  4. XM_011532015.3 → XP_011530317.1  neuropeptide Y receptor type 5 isoform X1

    See identical proteins and their annotated locations for XP_011530317.1

    Conserved Domains (2) summary
    pfam00001
    Location:65 → 432
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56 → 178
    7tm_4; Olfactory receptor

  5. XM_047415745.1 → XP_047271701.1  neuropeptide Y receptor type 5 isoform X1

  6. XM_017008255.2 → XP_016863744.1  neuropeptide Y receptor type 5 isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:65 → 432
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56 → 178
    7tm_4; Olfactory receptor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    166691703..166700212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350126.1 → XP_054206101.1  neuropeptide Y receptor type 5 isoform X2

    UniProtKB/Swiss-Prot
    Q15761, Q6GTR7, Q92916

  2. XM_054350125.1 → XP_054206100.1  neuropeptide Y receptor type 5 isoform X2

    UniProtKB/Swiss-Prot
    Q15761, Q6GTR7, Q92916

  3. XM_054350122.1 → XP_054206097.1  neuropeptide Y receptor type 5 isoform X1

  4. XM_054350121.1 → XP_054206096.1  neuropeptide Y receptor type 5 isoform X1

  5. XM_054350124.1 → XP_054206099.1  neuropeptide Y receptor type 5 isoform X1

  6. XM_054350123.1 → XP_054206098.1  neuropeptide Y receptor type 5 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15761.2 GenPept UniProtKB/Swiss-Prot:Q15761

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