NPY5R neuropeptide Y receptor Y5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NPY5Rprovided by HGNC
Official Full Name: neuropeptide Y receptor Y5provided by HGNC
Primary source: HGNC:HGNC:7958
See related: Ensembl:ENSG00000164129 MIM:602001
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NPYR5; NPY5-R; NPYY5-R
Summary: The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
Expression: Biased expression in spleen (RPKM 1.2), fat (RPKM 1.1) and 9 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 4q32.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109.20201120	current	GRCh38.p13 (GCF_000001405.39)	4	NC_000004.12 (163336968..163352277)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (164265062..164273540)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Y1R and Y5R might be the dominant receptors that mediate the effect of NPY-induced fat accumulation in both subcutaneous and visceral adipose tissues. Y1R and Y5R in visceral adipose tissue might be targets of drug development in prevention or treatment of obesity.
Title: Adipose Y5R mRNA is higher in obese than non-obese humans and is correlated with obesity parameters.
NPY5R is an inducible pro-survival factor that is responsible for chemoresistance in neuroblastoma cells.
Title: Neuropeptide Y receptor Y5 as an inducible pro-survival factor in neuroblastoma: implications for tumor chemoresistance.
Variations in genes AGRP, CPE, GHRL, GLP1R, HTR2A, NPY1R, NPY5R, SOCS3 and STAT3 showed modest associations with BMI in European Americans.
Title: Genetic association analysis of 30 genes related to obesity in a European American population.
these data highlight a novel mechanism by which NPY may promote breast cancer progression, and further implicate a pathological role of the NPY Y5R.
Title: Neuropeptide Y Y5-receptor activation on breast cancer cells acts as a paracrine system that stimulates VEGF expression and secretion to promote angiogenesis.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT.
Together, our results suggest that Y5R plays an important role in cancer cell growth and migration and could be a novel therapeutic target for breast cancer.
Title: Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line.
NPY1R and NPY5R have roles in nutrient-specific food intake in Europeans
Title: Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans.
Results suggest that rabbit and human Y1, Y2 and Y5 receptor subtypes are well conserved, whereas Y4 receptors are less well conserved.
Title: Cloning and characterization of rabbit neuropeptide Y receptor subtypes.
Sequence variations in neuropeptide Y receptor genes (NPY5R and NPY2R) are associated with alcohol dependence, cocaine dependence, and comorbid alcohol and cocaine dependence.
Title: Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NPY5R_960 (e-PCR)
- UniSTS:277538

NPY5R_V236 (e-PCR)
- UniSTS:277538

PMC310777P8 (e-PCR)
- UniSTS:272692

PMC310777P9 (e-PCR)
- UniSTS:272693

Homology

Homologs of the NPY5R gene: The NPY5R gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 259 organisms have orthologs with human gene NPY5R
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
neuropeptide Y receptor activity	TAS Traceable Author Statement more info	PubMed
pancreatic polypeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
peptide YY receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info
aging	IEA Inferred from Electronic Annotation more info
cardiac left ventricle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info	PubMed
eating behavior	IEA Inferred from Electronic Annotation more info
generation of ovulation cycle rhythm	IEA Inferred from Electronic Annotation more info
negative regulation of acute inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
negative regulation of glutamate secretion	IEA Inferred from Electronic Annotation more info
negative regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
positive regulation of acute inflammatory response	IEA Inferred from Electronic Annotation more info
positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
integral component of plasma membrane	TAS Traceable Author Statement more info	PubMed
membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
neuron projection	IBA Inferred from Biological aspect of Ancestor more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuropeptide Y receptor type 5

Names: NPY-Y5 receptor; Y5 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001317091.2 → NP_001304020.1 neuropeptide Y receptor type 5

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

BC034224

Consensus CDS

CCDS3804.1

UniProtKB/Swiss-Prot

Q15761

Related

ENSP00000423917.1, ENST00000515560.1

Conserved Domains (1) summary

cd15398
Location:42 → 436

7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001317092.2 → NP_001304021.1 neuropeptide Y receptor type 5

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

BC042416, HY025097

Consensus CDS

CCDS3804.1

UniProtKB/Swiss-Prot

Q15761

Conserved Domains (1) summary

cd15398
Location:42 → 436

7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_006174.4 → NP_006165.1 neuropeptide Y receptor type 5

See identical proteins and their annotated locations for NP_006165.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

BC042416, BI464162

Consensus CDS

CCDS3804.1

UniProtKB/Swiss-Prot

Q15761

Related

ENSP00000339377.3, ENST00000338566.8

Conserved Domains (1) summary

cd15398
Location:42 → 436

7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p13 Primary Assembly

Range

163336968..163352277

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017008256.1 → XP_016863745.1 neuropeptide Y receptor type 5 isoform X1

Conserved Domains (2) summary

pfam00001
Location:65 → 432

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:56 → 178

7tm_4; Olfactory receptor
XM_011532017.2 → XP_011530319.1 neuropeptide Y receptor type 5 isoform X2

See identical proteins and their annotated locations for XP_011530319.1

UniProtKB/Swiss-Prot

Q15761

Conserved Domains (1) summary

cd15398
Location:42 → 436

7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011532015.2 → XP_011530317.1 neuropeptide Y receptor type 5 isoform X1

See identical proteins and their annotated locations for XP_011530317.1

Conserved Domains (2) summary

pfam00001
Location:65 → 432

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:56 → 178

7tm_4; Olfactory receptor
XM_005263038.3 → XP_005263095.1 neuropeptide Y receptor type 5 isoform X2

See identical proteins and their annotated locations for XP_005263095.1

UniProtKB/Swiss-Prot

Q15761

Conserved Domains (1) summary

cd15398
Location:42 → 436

7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_017008255.1 → XP_016863744.1 neuropeptide Y receptor type 5 isoform X1

Conserved Domains (2) summary

pfam00001
Location:65 → 432

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:56 → 178

7tm_4; Olfactory receptor