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NPY5R neuropeptide Y receptor Y5 [ Homo sapiens (human) ]

Gene ID: 4889, updated on 24-Nov-2020

Summary

Official Symbol
NPY5Rprovided by HGNC
Official Full Name
neuropeptide Y receptor Y5provided by HGNC
Primary source
HGNC:HGNC:7958
See related
Ensembl:ENSG00000164129 MIM:602001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPYR5; NPY5-R; NPYY5-R
Summary
The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
Expression
Biased expression in spleen (RPKM 1.2), fat (RPKM 1.1) and 9 other tissues See more
Orthologs

Genomic context

See NPY5R in Genome Data Viewer
Location:
4q32.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (163336968..163352277)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (164265062..164273540)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377517 Neighboring gene mitochondrial ribosomal protein S5 pseudogene Neighboring gene neuropeptide Y receptor Y1 Neighboring gene ribosomal protein L35a pseudogene 12 Neighboring gene transketolase like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
neuropeptide Y receptor activity TAS
Traceable Author Statement
more info
PubMed 
pancreatic polypeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide YY receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
cardiac left ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eating behavior IEA
Inferred from Electronic Annotation
more info
 
generation of ovulation cycle rhythm IEA
Inferred from Electronic Annotation
more info
 
negative regulation of acute inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glutamate secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neuropeptide Y receptor type 5
Names
NPY-Y5 receptor
Y5 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317091.2NP_001304020.1  neuropeptide Y receptor type 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    BC034224
    Consensus CDS
    CCDS3804.1
    UniProtKB/Swiss-Prot
    Q15761
    Related
    ENSP00000423917.1, ENST00000515560.1
    Conserved Domains (1) summary
    cd15398
    Location:42436
    7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001317092.2NP_001304021.1  neuropeptide Y receptor type 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    BC042416, HY025097
    Consensus CDS
    CCDS3804.1
    UniProtKB/Swiss-Prot
    Q15761
    Conserved Domains (1) summary
    cd15398
    Location:42436
    7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_006174.4NP_006165.1  neuropeptide Y receptor type 5

    See identical proteins and their annotated locations for NP_006165.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    BC042416, BI464162
    Consensus CDS
    CCDS3804.1
    UniProtKB/Swiss-Prot
    Q15761
    Related
    ENSP00000339377.3, ENST00000338566.8
    Conserved Domains (1) summary
    cd15398
    Location:42436
    7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    163336968..163352277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008256.1XP_016863745.1  neuropeptide Y receptor type 5 isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:65432
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56178
    7tm_4; Olfactory receptor
  2. XM_011532017.2XP_011530319.1  neuropeptide Y receptor type 5 isoform X2

    See identical proteins and their annotated locations for XP_011530319.1

    UniProtKB/Swiss-Prot
    Q15761
    Conserved Domains (1) summary
    cd15398
    Location:42436
    7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_011532015.2XP_011530317.1  neuropeptide Y receptor type 5 isoform X1

    See identical proteins and their annotated locations for XP_011530317.1

    Conserved Domains (2) summary
    pfam00001
    Location:65432
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56178
    7tm_4; Olfactory receptor
  4. XM_005263038.3XP_005263095.1  neuropeptide Y receptor type 5 isoform X2

    See identical proteins and their annotated locations for XP_005263095.1

    UniProtKB/Swiss-Prot
    Q15761
    Conserved Domains (1) summary
    cd15398
    Location:42436
    7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. XM_017008255.1XP_016863744.1  neuropeptide Y receptor type 5 isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:65432
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56178
    7tm_4; Olfactory receptor
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