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Npy2r neuropeptide Y receptor Y2 [ Mus musculus (house mouse) ]

Gene ID: 18167, updated on 2-Nov-2024

Summary

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Official Symbol
Npy2rprovided by MGI
Official Full Name
neuropeptide Y receptor Y2provided by MGI
Primary source
MGI:MGI:108418
See related
Ensembl:ENSMUSG00000028004 AllianceGenome:MGI:108418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NPY2-R
Summary
Enables peptide YY receptor activity. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Located in non-motile cilium. Is active in cilium. Is expressed in central nervous system; dorsal root ganglion; eye; and metanephros. Human ortholog(s) of this gene implicated in Huntington's disease; morbid obesity; and obesity. Orthologous to human NPY2R (neuropeptide Y receptor Y2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in adrenal adult (RPKM 1.5), genital fat pad adult (RPKM 1.1) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Npy2r in Genome Data Viewer
Location:
3 E3; 3 36.49 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (82445688..82455404, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (82538383..82548989, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08033 Neighboring gene predicted gene, 57713 Neighboring gene STARR-seq mESC enhancer starr_08035 Neighboring gene STARR-positive B cell enhancer mm9_chr3:82161796-82162097 Neighboring gene STARR-seq mESC enhancer starr_08038 Neighboring gene microtubule-associated protein 9 Neighboring gene predicted gene, 29999 Neighboring gene STARR-seq mESC enhancer starr_08040 Neighboring gene STARR-seq mESC enhancer starr_08041 Neighboring gene RNA binding motif protein 46

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Assessment of ethanol consumption and water drinking by NPY Y(2) receptor knockout mice. Thiele TE, et al. Peptides, 2004 Jun. PMID 15203244
  2. Peripheral-specific y2 receptor knockdown protects mice from high-fat diet-induced obesity. Shi YC, et al. Obesity (Silver Spring), 2011 Nov. PMID 21546930
  3. Neuropeptide Y-Y2 receptor knockout mice: influence of genetic background on anxiety-related behaviors. Zambello E, et al. Neuroscience, 2011 Mar 10. PMID 21055451
  4. The central and basolateral amygdala are critical sites of neuropeptide Y/Y2 receptor-mediated regulation of anxiety and depression. Tasan RO, et al. J Neurosci, 2010 May 5. PMID 20445054, Free PMC Article
  5. NPY Y2 receptor agonist PYY(3-36) inhibits diarrhea by reducing intestinal fluid secretion and slowing colonic transit in mice. Moriya R, et al. Peptides, 2010 Apr. PMID 19925840

See all (131) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional deletion of neuropeptide Y receptors type 2 in local synaptic networks of anteroventral BNST facilitates recall and increases return of fear.
    Title: Functional deletion of neuropeptide Y receptors type 2 in local synaptic networks of anteroventral BNST facilitates recall and increases return of fear.
  2. Neuropeptide Y Acts Directly on Cartilage Homeostasis and Exacerbates Progression of Osteoarthritis Through NPY2R.
    Title: Neuropeptide Y Acts Directly on Cartilage Homeostasis and Exacerbates Progression of Osteoarthritis Through NPY2R.
  3. A role for NPY-NPY2R signaling in albuminuric kidney disease.
    Title: A role for NPY-NPY2R signaling in albuminuric kidney disease.
  4. Combined loss of GLP1R and Y2R-signaling was not able to negate or attenuate the beneficial effects of RYGB on body weight and glucose homeostasis in mice, suggesting that a larger number of signaling pathways is involved or that the critical pathway has not yet been identified.
    Title: Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice.
  5. It was concluded that PYY signaling through Y2R is not required for the normal appetite-suppressing and body weight-lowering effects of Roux-en-Y gastric bypass in this global knockout mouse model.
    Title: The PYY/Y2R-Deficient Mouse Responds Normally to High-Fat Diet and Gastric Bypass Surgery.
  6. High Npy2r expression is associated with chronic social defeat stress.
    Title: iTRAQ-based proteomics suggests LRP6, NPY and NPY2R perturbation in the hippocampus involved in CSDS may induce resilience and susceptibility.
  7. These results indicate that endogenous PYY has a hypoalgesic effect on somatic thermal and visceral chemical pain. The effect on visceral pain seems to be mediated by peripheral Y2 receptors.
    Title: Visceral hyperalgesia caused by peptide YY deletion and Y2 receptor antagonism.
  8. NPY and agonists of Y2R and Y5R may be neuroprotective against oxygen-glucose deprivation-induced neuronal cell death in primary cortical cell cultures after delayed treatment. A Y2R agonist not only diminished transient cerebral ischemia-induced neuronal injury, but also improved functional outcome after delayed treatment. Y5 and especially Y2 receptors may be promising targets for neuroprotection against ischemic damage
    Title: Neuropeptide Y Y2 and Y5 receptors as promising targets for neuroprotection in primary neurons exposed to oxygen-glucose deprivation and in transient focal cerebral ischemia in rats.
  9. Findings suggest that neuropeptide Y is expressed by distinct populations of neurons can modulate afferent and efferent projections of the central amygdala via presynaptic Y2 receptors located at inhibitory and excitatory synapses.
    Title: Structure and function of the amygdaloid NPY system: NPY Y2 receptors regulate excitatory and inhibitory synaptic transmission in the centromedial amygdala.
  10. confirms the critical role of Y2 signalling to control neuropeptide Y and associated pro-opiomelanocortin expression in the arcuate nuclei
    Title: Y2 receptor signalling in NPY neurons controls bone formation and fasting induced feeding but not spontaneous feeding.
Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC124241, MGC124242, MGC124244

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables neuropeptide Y receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neuropeptide Y receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide YY receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide YY receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in behavioral fear response ISO
Inferred from Sequence Orthology
more info
  
involved_in cardiac left ventricle morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cardiac left ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nervous system process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptide secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in secretion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neuropeptide Y receptor type 2
Names
NPY-Y2 receptor
Y2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205099.2 → NP_001192028.1  neuropeptide Y receptor type 2 isoform 2

    See identical proteins and their annotated locations for NP_001192028.1

    Status: VALIDATED

    Source sequence(s)
    AC091478
    Consensus CDS
    CCDS57219.1
    UniProtKB/TrEMBL
    Q3SWR9
    Related
    ENSMUSP00000138559.2, ENSMUST00000182181.8
    Conserved Domains (1) summary
    pfam00001
    Location:30 → 212
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. NM_001410443.1 → NP_001397372.1  neuropeptide Y receptor type 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC091478
    UniProtKB/Swiss-Prot
    F7C6W7, P97295, Q8BWV1
    Related
    ENSMUSP00000029633.5, ENSMUST00000029633.5

  3. NM_001410444.1 → NP_001397373.1  neuropeptide Y receptor type 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC091478
    UniProtKB/Swiss-Prot
    F7C6W7, P97295, Q8BWV1
    Related
    ENSMUSP00000138282.2, ENSMUST00000182831.2

  4. NM_001410445.1 → NP_001397374.1  neuropeptide Y receptor type 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC091478
    UniProtKB/Swiss-Prot
    F7C6W7, P97295, Q8BWV1

  5. NM_008731.4 → NP_032757.2  neuropeptide Y receptor type 2 isoform 1

    See identical proteins and their annotated locations for NP_032757.2

    Status: VALIDATED

    Source sequence(s)
    AC091478
    Consensus CDS
    CCDS59646.1
    UniProtKB/Swiss-Prot
    F7C6W7, P97295, Q8BWV1
    Related
    ENSMUSP00000096595.5, ENSMUST00000098997.5
    Conserved Domains (1) summary
    cd15399
    Location:51 → 336
    7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    82445688..82455404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97295.2 GenPept UniProtKB/Swiss-Prot:P97295

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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