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Npy2r neuropeptide Y receptor Y2 [ Mus musculus (house mouse) ]

Gene ID: 18167, updated on 13-Dec-2022

Summary

Official Symbol
Npy2rprovided by MGI
Official Full Name
neuropeptide Y receptor Y2provided by MGI
Primary source
MGI:MGI:108418
See related
Ensembl:ENSMUSG00000028004 AllianceGenome:MGI:108418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NPY2-R
Summary
Enables peptide YY receptor activity. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Located in non-motile cilium. Is expressed in central nervous system; dorsal root ganglion; eye; and metanephros. Human ortholog(s) of this gene implicated in Huntington's disease; morbid obesity; and obesity. Orthologous to human NPY2R (neuropeptide Y receptor Y2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 1.5), genital fat pad adult (RPKM 1.1) and 11 other tissues See more
Orthologs
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Genomic context

See Npy2r in Genome Data Viewer
Location:
3 E3; 3 36.49 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (82445690..82456310, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (82538383..82548989, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene microtubule-associated protein 9 Neighboring gene predicted gene, 29999 Neighboring gene RNA binding motif protein 46

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC124241, MGC124242, MGC124244

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables neuropeptide Y receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables neuropeptide Y receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide YY receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide YY receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in behavioral fear response ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac left ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of nervous system process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptide secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cilium ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neuropeptide Y receptor type 2
Names
NPY-Y2 receptor
Y2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205099.2NP_001192028.1  neuropeptide Y receptor type 2 isoform 2

    See identical proteins and their annotated locations for NP_001192028.1

    Status: VALIDATED

    Source sequence(s)
    AC091478
    Consensus CDS
    CCDS57219.1
    UniProtKB/TrEMBL
    Q3SWR9
    Related
    ENSMUSP00000138559.2, ENSMUST00000182181.8
    Conserved Domains (1) summary
    pfam00001
    Location:30212
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_001410443.1NP_001397372.1  neuropeptide Y receptor type 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC091478
    UniProtKB/Swiss-Prot
    Q8BWV1
  3. NM_001410444.1NP_001397373.1  neuropeptide Y receptor type 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC091478
    UniProtKB/Swiss-Prot
    Q8BWV1
  4. NM_001410445.1NP_001397374.1  neuropeptide Y receptor type 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC091478
    UniProtKB/Swiss-Prot
    Q8BWV1
  5. NM_008731.4NP_032757.2  neuropeptide Y receptor type 2 isoform 1

    See identical proteins and their annotated locations for NP_032757.2

    Status: VALIDATED

    Source sequence(s)
    AC091478
    Consensus CDS
    CCDS59646.1
    UniProtKB/Swiss-Prot
    P97295, Q8BWV1
    Related
    ENSMUSP00000096595.5, ENSMUST00000098997.5
    Conserved Domains (1) summary
    cd15399
    Location:51336
    7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    82445690..82456310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501115.2XP_006501178.1  neuropeptide Y receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P97295
    Related
    ENSMUSP00000138282.2, ENSMUST00000182831.2
    Conserved Domains (1) summary
    cd15399
    Location:51336
    7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_006501116.2XP_006501179.1  neuropeptide Y receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    P97295
    Related
    ENSMUSP00000029633.5, ENSMUST00000029633.5
    Conserved Domains (1) summary
    cd15399
    Location:51336
    7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors