NPY2R neuropeptide Y receptor Y2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NPY2Rprovided by HGNC
Official Full Name: neuropeptide Y receptor Y2provided by HGNC
Primary source: HGNC:HGNC:7957
See related: Ensembl:ENSG00000185149 MIM:162642; AllianceGenome:HGNC:7957
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NPY2-R
Summary: Predicted to enable calcium channel regulator activity and neuropeptide Y receptor activity. Involved in cardiac left ventricle morphogenesis and outflow tract morphogenesis. Located in cilium. Implicated in Huntington's disease; morbid obesity; and obesity. Biomarker of peripheral artery disease and temporal lobe epilepsy. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 4q32.1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (155173723..155217076)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (158505608..158548978)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (156094875..156138228)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.
Title: Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.
Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients.
Title: Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients.
The analysis of the distribution of genotypes in CEP135 rs4865047 and NPY2R rs1902491 detected significant differences only in the single nucleotide polymorphism rs4865047 genotype between the case and control group in comparison to the reference group. No significant association was found for the NPY2R SNP rs1902491 genotype.
Title: The Association of CEP135 rs4865047 and NPY2R rs1902491 Single Nucleotide Polymorphisms (SNPs) with Rapid Progression of Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes Mellitus.
genetic variation in NPY and NPY2R is at low frequency and thus does not make a major contribution to the obese phenotype in the general population
Title: Evaluation of a Role for NPY and NPY2R in the Pathogenesis of Obesity by Mutation and Copy Number Variation Analysis in Obese Children and Adolescents.
The present study explored whether functional NPY2R variant rs6857715 (C-599T) showed an association with Major Depressive Disorder. Analysis of the overall sample (595 MDD cases; 1295 controls) showed an association with the AD risk allele C. The present findings suggest that the NPY2R rs6857715 C-allele makes a genuine contribution toward MDD
Title: Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder.
not detected in infantile hemanogiomas
Title: Neuropeptide Y receptor 1 is expressed by B and T lymphocytes and mast cells in infantile haemangiomas.
polymorphisms in the NPY2R gene may be useful in identifying women at risk for osteoporosis.
Title: Polymorphisms in neuropeptide genes and bone mineral density in Korean postmenopausal women.
The C-terminal alpha-helix of Neuropeptide Y, which is formed in a membrane environment in the absence of the receptor, is unwound starting at T(32) to provide optimal contacts in a binding pocket within the transmembrane bundle of the NPY-Y2 receptor.
Title: Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y₂ Receptor Binding and Activation.
Data show that the Y2-receptor high expression G allele is associated with a less efficient mode of action cascading where different task goals are activated in parallel.
Title: On the relevance of the NPY2-receptor variation for modes of action cascading processes.
The molecular mobility of the human neuropeptide Y receptor type 2 reconstituted into dimyristoylphosphatidylcholine (DMPC) membranes was investigated by means of solid-state NMR spectroscopy.
Title: The G-protein-coupled neuropeptide Y receptor type 2 is highly dynamic in lipid membranes as revealed by solid-state NMR spectroscopy.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NPY2R_V235 (e-PCR)
- UniSTS:280868

NPY2R_958.2 (e-PCR)
- UniSTS:280868

NoName (e-PCR)
- UniSTS:480593

PMC161419P2 (e-PCR)
- UniSTS:271452

SHGC-35647 (e-PCR)
- UniSTS:42614

STS-U42766 (e-PCR)
- UniSTS:13546

NoName (e-PCR)
- UniSTS:482294

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	TAS Traceable Author Statement more info	PubMed
enables neuropeptide Y receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide Y receptor activity	TAS Traceable Author Statement more info	PubMed
enables peptide YY receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in behavioral fear response	IEA Inferred from Electronic Annotation more info
involved_in cardiac left ventricle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory behavior	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cAMP/PKA signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of feeding behavior	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of nervous system process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-substrate adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dopamine secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptide secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synaptic signaling via neuropeptide	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in cilium	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in non-motile cilium	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
is_active_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuropeptide Y receptor type 2

Names: NPY-Y2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000910.4 → NP_000901.1 neuropeptide Y receptor type 2

See identical proteins and their annotated locations for NP_000901.1

Status: VALIDATED

Source sequence(s)

U36269, U42766

Consensus CDS

CCDS3791.1

UniProtKB/Swiss-Prot

P49146, Q13281, Q13457, Q4W5G7, Q6AZZ6, Q9UE67

Related

ENSP00000332591.3, ENST00000329476.4

Conserved Domains (1) summary

cd15399
Location:51 → 336

7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001370180.1 → NP_001357109.1 neuropeptide Y receptor type 2

Status: VALIDATED

Source sequence(s)

AC104407

Consensus CDS

CCDS3791.1

UniProtKB/Swiss-Prot

P49146, Q13281, Q13457, Q4W5G7, Q6AZZ6, Q9UE67

Related

ENSP00000426366.1, ENST00000506608.1

Conserved Domains (1) summary

cd15399
Location:51 → 336

7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001375470.1 → NP_001362399.1 neuropeptide Y receptor type 2

Status: VALIDATED

Source sequence(s)

AC104407

Consensus CDS

CCDS3791.1

UniProtKB/Swiss-Prot

P49146, Q13281, Q13457, Q4W5G7, Q6AZZ6, Q9UE67

Conserved Domains (1) summary

cd15399
Location:51 → 336

7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors