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NPY2R neuropeptide Y receptor Y2 [ Homo sapiens (human) ]

Gene ID: 4887, updated on 26-Oct-2022

Summary

Official Symbol
NPY2Rprovided by HGNC
Official Full Name
neuropeptide Y receptor Y2provided by HGNC
Primary source
HGNC:HGNC:7957
See related
Ensembl:ENSG00000185149 MIM:162642; AllianceGenome:HGNC:7957
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPY2-R
Summary
Predicted to enable calcium channel regulator activity and neuropeptide Y receptor activity. Involved in cardiac left ventricle morphogenesis and outflow tract morphogenesis. Located in cilium. Implicated in Huntington's disease; morbid obesity; and obesity. Biomarker of peripheral artery disease and temporal lobe epilepsy. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See NPY2R in Genome Data Viewer
Location:
4q32.1
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (155173723..155217076)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (158505608..158548978)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (156094875..156138228)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U2 small nuclear 44, pseudogene Neighboring gene RNA binding motif protein 46 Neighboring gene uncharacterized LOC105377501 Neighboring gene NPY2R antisense RNA 1 Neighboring gene uncharacterized LOC105377502 Neighboring gene MAP9 antisense RNA 1 Neighboring gene microtubule associated protein 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
enables neuropeptide Y receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide YY receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in non-motile cilium IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neuropeptide Y receptor type 2
Names
NPY-Y2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000910.4NP_000901.1  neuropeptide Y receptor type 2

    See identical proteins and their annotated locations for NP_000901.1

    Status: VALIDATED

    Source sequence(s)
    U36269, U42766
    Consensus CDS
    CCDS3791.1
    UniProtKB/Swiss-Prot
    P49146, Q9UE67
    Related
    ENSP00000332591.3, ENST00000329476.4
    Conserved Domains (1) summary
    cd15399
    Location:51336
    7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001370180.1NP_001357109.1  neuropeptide Y receptor type 2

    Status: VALIDATED

    Source sequence(s)
    AC104407
    Consensus CDS
    CCDS3791.1
    UniProtKB/Swiss-Prot
    Q9UE67
    Related
    ENSP00000426366.1, ENST00000506608.1
    Conserved Domains (1) summary
    cd15399
    Location:51336
    7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001375470.1NP_001362399.1  neuropeptide Y receptor type 2

    Status: VALIDATED

    Source sequence(s)
    AC104407
    Consensus CDS
    CCDS3791.1
    UniProtKB/Swiss-Prot
    Q9UE67
    Conserved Domains (1) summary
    cd15399
    Location:51336
    7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    155173723..155217076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    158505608..158548978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)