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NPY2R neuropeptide Y receptor Y2 [ Homo sapiens (human) ]

Gene ID: 4887, updated on 2-Mar-2021

Summary

Official Symbol
NPY2Rprovided by HGNC
Official Full Name
neuropeptide Y receptor Y2provided by HGNC
Primary source
HGNC:HGNC:7957
See related
Ensembl:ENSG00000185149 MIM:162642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPY2-R
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See NPY2R in Genome Data Viewer
Location:
4q32.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (155173723..155217076)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (156094875..156138228)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U2 small nuclear 44, pseudogene Neighboring gene RNA binding motif protein 46 Neighboring gene uncharacterized LOC105377501 Neighboring gene uncharacterized LOC107986321 Neighboring gene uncharacterized LOC105377502 Neighboring gene uncharacterized LOC102724776 Neighboring gene microtubule associated protein 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
neuropeptide Y receptor activity TAS
Traceable Author Statement
more info
PubMed 
peptide YY receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
cardiac left ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotory behavior TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
negative regulation of feeding behavior IEA
Inferred from Electronic Annotation
more info
 
negative regulation of nervous system process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
nitric oxide mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of circadian sleep/wake cycle, non-REM sleep IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dopamine secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptide secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
secretion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cilium IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
non-motile cilium IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neuropeptide Y receptor type 2
Names
NPY-Y2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000910.4NP_000901.1  neuropeptide Y receptor type 2

    See identical proteins and their annotated locations for NP_000901.1

    Status: VALIDATED

    Source sequence(s)
    U36269, U42766
    Consensus CDS
    CCDS3791.1
    UniProtKB/Swiss-Prot
    P49146
    Related
    ENSP00000332591.3, ENST00000329476.4
    Conserved Domains (1) summary
    cd15399
    Location:51336
    7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001370180.1NP_001357109.1  neuropeptide Y receptor type 2

    Status: VALIDATED

    Source sequence(s)
    AC104407
    Related
    ENSP00000426366.1, ENST00000506608.1
    Conserved Domains (1) summary
    cd15399
    Location:51336
    7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001375470.1NP_001362399.1  neuropeptide Y receptor type 2

    Status: VALIDATED

    Source sequence(s)
    AC104407
    Conserved Domains (1) summary
    cd15399
    Location:51336
    7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    155173723..155217076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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