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Emc8 ER membrane protein complex subunit 8 [ Mus musculus (house mouse) ]

Gene ID: 18117, updated on 12-May-2024


Official Symbol
Emc8provided by MGI
Official Full Name
ER membrane protein complex subunit 8provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000031819 AllianceGenome:MGI:1343095
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Noc4; Cox4nb; Fam158b
Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human EMC8 (ER membrane protein complex subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in ovary adult (RPKM 15.9), adrenal adult (RPKM 11.0) and 28 other tissues See more
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Genomic context

See Emc8 in Genome Data Viewer
8 E1; 8 69.98 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (121380653..121394826, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (120653914..120668087, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10614 Neighboring gene RIKEN cDNA 1190005I06 gene Neighboring gene predicted gene, 27021 Neighboring gene STARR-seq mESC enhancer starr_22909 Neighboring gene predicted gene, 33075 Neighboring gene cytochrome c oxidase subunit 4I1 Neighboring gene predicted gene, 39265

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 


Products Interactant Other Gene Complex Source Pubs Description

General gene information

Readthrough Gm27021

Readthrough gene: Gm27021, Included gene: 1190005I06Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to membrane insertase activity ISO
Inferred from Sequence Orthology
more info
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
part_of EMC complex ISO
Inferred from Sequence Orthology
more info
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
located_in membrane IEA
Inferred from Electronic Annotation
more info
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
ER membrane protein complex subunit 8
COX4 neighbor
neighbor of Cox4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010926.6NP_035056.1  ER membrane protein complex subunit 8

    See identical proteins and their annotated locations for NP_035056.1

    Status: VALIDATED

    Source sequence(s)
    Consensus CDS
    Q3TPU5, Q3TTC9, Q8C988
    ENSMUSP00000034277.7, ENSMUST00000034277.14
    Conserved Domains (1) summary
    MPN_UPF0172; Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000074.7 Reference GRCm39 C57BL/6J

    121380653..121394826 complement
    GenBank, FASTA, Sequence Viewer (Graphics)