Emc8 ER membrane protein complex subunit 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Emc8provided by MGI
Official Full Name: ER membrane protein complex subunit 8provided by MGI
Primary source: MGI:MGI:1343095
See related: Ensembl:ENSMUSG00000031819 AllianceGenome:MGI:1343095
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Noc4; Cox4nb; Fam158b
Summary: Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human EMC8 (ER membrane protein complex subunit 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 15.9), adrenal adult (RPKM 11.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 69.98 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (121380653..121394826, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (120653914..120668087, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Readthrough Gm27021

Readthrough gene: Gm27021, Included gene: 1190005I06Rik

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to membrane insertase activity	ISO Inferred from Sequence Orthology more info
contributes_to membrane insertase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISS Inferred from Sequence or Structural Similarity more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of EMC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of EMC complex	ISO Inferred from Sequence Orthology more info
part_of EMC complex	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	NAS Non-traceable Author Statement more info	PubMed
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: ER membrane protein complex subunit 8

Names: COX4 neighbor; neighbor of Cox4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010926.6 → NP_035056.1 ER membrane protein complex subunit 8

See identical proteins and their annotated locations for NP_035056.1

Status: VALIDATED

Source sequence(s)

AC103360

Consensus CDS

CCDS22719.1

UniProtKB/Swiss-Prot

O70378

UniProtKB/TrEMBL

Q3TPU5, Q3TTC9, Q8C988

Related

ENSMUSP00000034277.7, ENSMUST00000034277.14

Conserved Domains (1) summary

cd08060
Location:6 → 196

MPN_UPF0172; Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p)