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EMC8 ER membrane protein complex subunit 8 [ Homo sapiens (human) ]

Gene ID: 10328, updated on 7-Jun-2020

Summary

Official Symbol
EMC8provided by HGNC
Official Full Name
ER membrane protein complex subunit 8provided by HGNC
Primary source
HGNC:HGNC:7864
See related
Ensembl:ENSG00000131148 MIM:604886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOC4; COX4NB; C16orf2; C16orf4; FAM158B
Expression
Ubiquitous expression in bone marrow (RPKM 7.1), testis (RPKM 6.1) and 25 other tissues See more
Orthologs

Genomic context

See EMC8 in Genome Data Viewer
Location:
16q24.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (85778624..85799555, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (85812230..85833161, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Gse1 coiled-coil protein Neighboring gene GINS complex subunit 2 Neighboring gene chromosome 16 open reading frame 74 Neighboring gene microRNA 1910 Neighboring gene uncharacterized LOC101928557 Neighboring gene iron-sulfur cluster assembly 1 homolog (S. cerevisiae) pseudogene Neighboring gene RNA, U1 small nuclear 103, pseudogene Neighboring gene cytochrome c oxidase subunit 4I1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
ER membrane protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER membrane protein complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ER membrane protein complex subunit 8
Names
COX4 neighbor
family with sequence similarity 158, member B
neighbor of COX4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142288.2NP_001135760.1  ER membrane protein complex subunit 8 isoform 2

    See identical proteins and their annotated locations for NP_001135760.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AC018695, BE855452, BP307869
    Consensus CDS
    CCDS45541.1
    UniProtKB/Swiss-Prot
    O43402
    Related
    ENSP00000391730.1, ENST00000435200.2
    Conserved Domains (1) summary
    cd08060
    Location:6126
    MPN_UPF0172; Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p)
  2. NM_006067.5NP_006058.1  ER membrane protein complex subunit 8 isoform 1

    See identical proteins and their annotated locations for NP_006058.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC018695, BC020250, BP307869
    Consensus CDS
    CCDS10954.1
    UniProtKB/Swiss-Prot
    O43402
    UniProtKB/TrEMBL
    Q53Y03
    Related
    ENSP00000253457.3, ENST00000253457.8
    Conserved Domains (1) summary
    cd08060
    Location:6199
    MPN_UPF0172; Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    85778624..85799555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022867.1XP_016878356.1  ER membrane protein complex subunit 8 isoform X1

  2. XM_011522813.3XP_011521115.1  ER membrane protein complex subunit 8 isoform X2

    Conserved Domains (1) summary
    cd08060
    Location:6103
    MPN_UPF0172; Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p)

RNA

  1. XR_001751817.2 RNA Sequence

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