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C17H11.6 RBR-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

Gene ID: 181076, updated on 23-Nov-2023

Summary

Gene symbol
C17H11.6
Gene description
RBR-type E3 ubiquitin transferase
Primary source
WormBase:WBGene00015926
Locus tag
CELE_C17H11.6
See related
AllianceGenome:WB:WBGene00015926
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including hypodermis; intestine; nervous system; pharyngeal-intestinal valve; and reproductive system. Orthologous to several human genes including RNF19B (ring finger protein 19B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See C17H11.6 in Genome Data Viewer
Location:
chromosome: X
Exon count:
17
Sequence:
Chromosome: X; NC_003284.9 (8185164..8203779, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene FERM domain-containing protein Neighboring gene Phage protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cytidine deaminase

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
RBR-type E3 ubiquitin transferase
NP_001123112.1
  • Confirmed by transcript evidence
NP_001300318.1
  • Confirmed by transcript evidence
NP_001300319.1
  • Confirmed by transcript evidence
NP_001379690.1
  • Confirmed by transcript evidence
NP_509383.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    8185164..8203779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076982.6NP_509383.2  RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95Q83
    Conserved Domains (3) summary
    smart00647
    Location:123188
    IBR; In Between Ring fingers
    cl00570
    Location:288384
    AzlC; AzlC protein
    cl19760
    Location:224262
    IBR; IBR domain, a half RING-finger domain
  2. NM_001392809.1NP_001379690.1  RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86ME0
    Conserved Domains (4) summary
    smart00647
    Location:153218
    IBR; In Between Ring fingers
    cd16629
    Location:84138
    RING-HC_RBR_RNF19; RING finger, HC subclass, found in the family of RING finger proteins RNF19A, RNF19B and similar proteins
    pfam01485
    Location:254292
    IBR; IBR domain, a half RING-finger domain
    cl00570
    Location:318414
    AzlC; AzlC protein
  3. NM_001129640.5NP_001123112.1  RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123112.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B1Q249
    Conserved Domains (3) summary
    smart00647
    Location:268333
    IBR; In Between Ring fingers
    pfam01485
    Location:369407
    IBR; IBR domain, a half RING-finger domain
    cl00570
    Location:433529
    AzlC; AzlC protein
  4. NM_001313389.4NP_001300318.1  RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AW92
  5. NM_001313390.4NP_001300319.1  RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AYH3