C17H11.6 RBR-type E3 ubiquitin transferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: C17H11.6
Official Full Name: RBR-type E3 ubiquitin transferase
Primary source: WormBase:WBGene00015926
Locus tag: CELE_C17H11.6
See related: AllianceGenome:WB:WBGene00015926
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including hypodermis; intestine; nervous system; pharyngeal-intestinal valve; and reproductive system. Orthologous to human RNF19A (ring finger protein 19A, RBR E3 ubiquitin protein ligase) and RNF19B (ring finger protein 19B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See C17H11.6 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 17

Sequence:: Chromosome: X; NC_003284.9 (8185164..8203779, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

C17H11.6 (e-PCR)
- UniSTS:306740

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RBR-type E3 ubiquitin transferase

NP_001123112.1

Confirmed by transcript evidence

NP_001300318.1

Confirmed by transcript evidence

NP_001300319.1

Confirmed by transcript evidence

NP_001379690.1

Confirmed by transcript evidence

NP_509383.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

8185164..8203779 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076982.6 → NP_509383.2 RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q95Q83

Conserved Domains (3) summary

smart00647
Location:123 → 188

IBR; In Between Ring fingers

cl00570
Location:288 → 384

AzlC; AzlC protein

cl19760
Location:224 → 262

IBR; IBR domain, a half RING-finger domain
NM_001392809.1 → NP_001379690.1 RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q86ME0

Conserved Domains (4) summary

smart00647
Location:153 → 218

IBR; In Between Ring fingers

cd16629
Location:84 → 138

RING-HC_RBR_RNF19; RING finger, HC subclass, found in the family of RING finger proteins RNF19A, RNF19B and similar proteins

pfam01485
Location:254 → 292

IBR; IBR domain, a half RING-finger domain

cl00570
Location:318 → 414

AzlC; AzlC protein
NM_001129640.5 → NP_001123112.1 RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001123112.1

Status: REVIEWED

UniProtKB/TrEMBL

B1Q249

Conserved Domains (3) summary

smart00647
Location:268 → 333

IBR; In Between Ring fingers

pfam01485
Location:369 → 407

IBR; IBR domain, a half RING-finger domain

cl00570
Location:433 → 529

AzlC; AzlC protein
NM_001313389.4 → NP_001300318.1 RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AW92
NM_001313390.4 → NP_001300319.1 RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AYH3