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Nlk nemo like kinase [ Mus musculus (house mouse) ]

Gene ID: 18099, updated on 12-May-2024

Summary

Official Symbol
Nlkprovided by MGI
Official Full Name
nemo like kinaseprovided by MGI
Primary source
MGI:MGI:1201387
See related
Ensembl:ENSMUSG00000017376 AllianceGenome:MGI:1201387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables several functions, including ATP binding activity; SH2 domain binding activity; and magnesium ion binding activity. Involved in several processes, including intracellular signal transduction; negative regulation of Wnt signaling pathway; and protein phosphorylation. Acts upstream of or within protein autophosphorylation. Located in nucleus. Is expressed in several structures, including early embryo; genitourinary system; nervous system; neural retina; and respiratory system. Orthologous to human NLK (nemo like kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 16.4), frontal lobe adult (RPKM 14.0) and 28 other tissues See more
Orthologs
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Genomic context

See Nlk in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78457994..78588848, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78567168..78697595, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L10 pseudogene Neighboring gene predicted gene, 22947 Neighboring gene annexin A2 pseudogene Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene STARR-seq mESC enhancer starr_30101 Neighboring gene STARR-positive B cell enhancer ABC_E1143 Neighboring gene STARR-positive B cell enhancer ABC_E2361 Neighboring gene 40S ribosomal protein SA-like Neighboring gene STARR-seq mESC enhancer starr_30102 Neighboring gene cyclin Q

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables SH2 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase NLK
NP_032728.3
XP_036012300.1
XP_036012301.1
XP_036012302.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008702.3NP_032728.3  serine/threonine-protein kinase NLK

    See identical proteins and their annotated locations for NP_032728.3

    Status: VALIDATED

    Source sequence(s)
    AK078118, AK160340, BU923375, BY137033, BY237029, CB234984, CO042120
    Consensus CDS
    CCDS25113.2
    UniProtKB/Swiss-Prot
    O54949, Q5SYE6, Q6PF98
    Related
    ENSMUSP00000119345.2, ENSMUST00000142739.8
    Conserved Domains (1) summary
    cd07853
    Location:137508
    STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    78457994..78588848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156409.1XP_036012302.1  serine/threonine-protein kinase NLK isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1287
    PKc_like; Protein Kinases, catalytic domain
  2. XM_036156408.1XP_036012301.1  serine/threonine-protein kinase NLK isoform X2

    Conserved Domains (1) summary
    cd07853
    Location:2356
    STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
  3. XM_036156407.1XP_036012300.1  serine/threonine-protein kinase NLK isoform X1

    Conserved Domains (1) summary
    cd07853
    Location:22376
    STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

RNA

  1. XR_001779914.2 RNA Sequence