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NLK nemo like kinase [ Homo sapiens (human) ]

Gene ID: 51701, updated on 8-Dec-2022

Summary

Official Symbol
NLKprovided by HGNC
Official Full Name
nemo like kinaseprovided by HGNC
Primary source
HGNC:HGNC:29858
See related
Ensembl:ENSG00000087095 MIM:609476; AllianceGenome:HGNC:29858
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables ubiquitin protein ligase binding activity. Involved in protein stabilization and transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 18.0), adrenal (RPKM 18.0) and 25 other tissues See more
Orthologs
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Genomic context

See NLK in Genome Data Viewer
Location:
17q11.2
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (28042677..28206074)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (28984080..29137796)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26369703..26523407)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC105371709 Neighboring gene Sharpr-MPRA regulatory region 3957 Neighboring gene uncharacterized LOC102724517 Neighboring gene ribosomal protein S29 pseudogene 22 Neighboring gene uncharacterized LOC105371711 Neighboring gene uncharacterized LOC105371710 Neighboring gene uncharacterized LOC105371712 Neighboring gene peptide YY 2 (pseudogene) Neighboring gene pancreatic polypeptide 2, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu In vitro protein-protein interaction analysis identifies a Vpu-binding host protein nemo-like kinase (NLK) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21033, DKFZp761G1211

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables SH2 domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway, calcium modulating pathway TAS
Traceable Author Statement
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in serine phosphorylation of STAT protein ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase NLK
NP_057315.3
XP_005258045.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016231.5NP_057315.3  serine/threonine-protein kinase NLK

    See identical proteins and their annotated locations for NP_057315.3

    Status: VALIDATED

    Source sequence(s)
    AC090287, AK024686, AL036279, BM723604, BQ636970, DA224552, DA573077, U69562
    Consensus CDS
    CCDS11224.2
    UniProtKB/Swiss-Prot
    Q6P2A3, Q9UBE8
    UniProtKB/TrEMBL
    A0A024QZ12
    Related
    ENSP00000384625.3, ENST00000407008.8
    Conserved Domains (1) summary
    cd07853
    Location:137508
    STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    28042677..28206074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257988.3XP_005258045.1  serine/threonine-protein kinase NLK isoform X1

    See identical proteins and their annotated locations for XP_005258045.1

    Conserved Domains (1) summary
    cd07853
    Location:137479
    STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

RNA

  1. XR_934482.2 RNA Sequence

  2. XR_001752526.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    28984080..29137796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)