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pks-1 Fatty acid synthase [ Caenorhabditis elegans ]

Gene ID: 180815, updated on 2-May-2024

Summary

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Gene symbol
pks-1
Gene description
Fatty acid synthase
Primary source
WormBase:WBGene00016558
Locus tag
CELE_C41A3.1
See related
AllianceGenome:WB:WBGene00016558
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable fatty acid synthase activity. Predicted to be involved in fatty acid biosynthetic process. Is expressed in CANL and CANR. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
31
Sequence:
Chromosome: X; NC_003284.9 (5413810..5441961)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene tRNA-Met Neighboring gene Coiled-coil domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan. Feng L, et al. Nat Commun, 2021 Aug 13. PMID 34389721, Free PMC Article
  2. A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival. Shou Q, et al. Nat Chem Biol, 2016 Oct. PMID 27501395, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan.
    Title: Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acyl-[ACP] hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphopantetheine binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in monocarboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in organic cyclic compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in organonitrogen compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in secondary metabolite biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Fatty acid synthase
NP_001317900.1
  • Confirmed by transcript evidence
NP_508923.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5413810..5441961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330898.4 → NP_001317900.1  Fatty acid synthase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1C3NSM6

  2. NM_076522.3 → NP_508923.2  Fatty acid synthase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508923.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18559
    Conserved Domains (16) summary
    PRK14691
    Location:4335 → 4629
    PRK14691; 3-oxoacyl-(acyl carrier protein) synthase II; Provisional
    smart00822
    Location:3203 → 3377
    PKS_KR; This enzymatic domain is part of bacterial polyketide synthases
    smart00823
    Location:2943 → 3024
    PKS_PP; Phosphopantetheine attachment site
    smart00825
    Location:1891 → 2282
    PKS_KS; Beta-ketoacyl synthase
    smart00827
    Location:3649 → 3927
    PKS_AT; Acyl transferase domain in polyketide synthase (PKS) enzymes
    COG3321
    Location:3609 → 3984
    PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
    cd00833
    Location:5258 → 5645
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    TIGR01733
    Location:7000 → 7356
    AA-adenyl-dom; amino acid adenylation domain
    pfam00550
    Location:6476 → 6539
    PP-binding; Phosphopantetheine attachment site
    pfam16197
    Location:376 → 433
    KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
    cl00509
    Location:1544 → 1759
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
    cl08282
    Location:5761 → 6023
    Acyl_transf_1; Acyl transferase domain
    cl17068
    Location:6990 → 7412
    AFD_class_I; Adenylate forming domain, Class I superfamily
    cl21454
    Location:4991 → 5131
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    cl21494
    Location:7527 → 7622
    Abhydrolase; alpha/beta hydrolases
    cl23853
    Location:6558 → 6831
    Condensation; Condensation domain
Nucleotide Protein
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