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DPYSL2 dihydropyrimidinase like 2 [ Homo sapiens (human) ]

Gene ID: 1808, updated on 27-Nov-2024

Summary

Official Symbol
DPYSL2provided by HGNC
Official Full Name
dihydropyrimidinase like 2provided by HGNC
Primary source
HGNC:HGNC:3014
See related
Ensembl:ENSG00000092964 MIM:602463; AllianceGenome:HGNC:3014
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2
Summary
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Annotation information
Note: DRP2 (Gene ID: 1821) and DPYSL2 (Gene ID: 1808) share the DRP2 symbol/alias in common. DRP2 is a widely used alternative name for dihydropyrimidinase like 2 (DPYSL2), which can be confused with the official symbol for dystrophin related protein 2 (DRP2). [06 Jul 2018]
Expression
Broad expression in brain (RPKM 146.0), lung (RPKM 48.2) and 15 other tissues See more
Orthologs
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Genomic context

See DPYSL2 in Genome Data Viewer
Location:
8p21.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (26514031..26658175)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (26790610..26934895)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (26371547..26515691)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene vegetative cell wall protein gp1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:26346103-26346626 Neighboring gene Sharpr-MPRA regulatory region 13991 Neighboring gene PNMA family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:26433901-26434598 Neighboring gene proteasome activator subunit 2 pseudogene 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:26434599-26435296 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:26435598-26436492 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:26436493-26437387 Neighboring gene uncharacterized LOC124901916 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:26448723-26449328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27130 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:26485007-26485506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27131 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:26494036-26495000 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:26495001-26495965 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:26500941-26501851 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:26518635-26519136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:26519137-26519636 Neighboring gene adrenoceptor alpha 1A Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 9 Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat induces hyperphosphorylation of CRMP2 in neuronal cells PubMed
tat Expression of HIV-1 Tat upregulates the abundance of dihydropyrimidinase-like 2 (DPYSL2, CRMP2) in the nucleoli of Jurkat T-cells PubMed
tat A peptide of CRMP-2 fused to the HIV transactivator of transcription Tat protein decreases neuropeptide release from sensory neurons PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables dihydropyrimidinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
NOT involved_in pyrimidine nucleobase catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
colocalizes_with membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
dihydropyrimidinase-related protein 2
Names
collapsin response mediator protein hCRMP-2
unc-33-like phosphoprotein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030020.1 RefSeqGene

    Range
    4839..148983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001197293.3NP_001184222.1  dihydropyrimidinase-related protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001184222.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB209195, AC015564, AC015743, BC056408, BX463316, DA649686
    Consensus CDS
    CCDS83268.1
    UniProtKB/TrEMBL
    A0A1C7CYX9, Q59GB4
    Related
    ENSP00000427985.2, ENST00000521913.7
    Conserved Domains (1) summary
    cd01314
    Location:122571
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
  2. NM_001244604.2NP_001231533.1  dihydropyrimidinase-related protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001231533.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC015564, AK299077, BC056408, BP222303, BX463316
    Consensus CDS
    CCDS59096.1
    UniProtKB/TrEMBL
    Q53ET2
    Related
    ENSP00000431117.1, ENST00000523027.1
    Conserved Domains (1) summary
    cd01314
    Location:1430
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
  3. NM_001386.6NP_001377.1  dihydropyrimidinase-related protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001377.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC015564, BC056408, BX461557, DC333865
    Consensus CDS
    CCDS6051.1
    UniProtKB/Swiss-Prot
    A8K5H2, B4DR31, D3DSS7, O00424, Q16555
    UniProtKB/TrEMBL
    Q53ET2
    Related
    ENSP00000309539.5, ENST00000311151.9
    Conserved Domains (1) summary
    cd01314
    Location:17466
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    26514031..26658175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    26790610..26934895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)