C07A12.7 TOM1-like protein 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: C07A12.7
Official Full Name: TOM1-like protein 2
Primary source: WormBase:WBGene00015561
Locus tag: CELE_C07A12.7
See related: AllianceGenome:WB:WBGene00015561
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable clathrin binding activity. Predicted to be involved in signal transduction. Predicted to be active in endosome and membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to several human genes including TOM1L2 (target of myb1 like 2 membrane trafficking protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: X

Exon count:: 8

Sequence:: Chromosome: X; NC_003284.9 (4517747..4521051, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C07A12.7 (e-PCR)
- UniSTS:313504

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TOM1-like protein 2

NP_508776.1

Confirmed by transcript evidence

NP_508777.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4517747..4521051 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076376.8 → NP_508777.1 TOM1-like protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508777.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95QX5

Conserved Domains (2) summary

cd14233
Location:251 → 336

GAT_TOM1_like; GAT domain found in target of myb protein 1 (Tom1) protein family

cd03565
Location:38 → 176

VHS_Tom1_like; VHS (Vps27/Hrs/STAM) domain of Tom1 subfamily
NM_076375.6 → NP_508776.1 TOM1-like protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508776.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KYH5

Conserved Domains (2) summary

cd14233
Location:217 → 302

GAT_TOM1_like; GAT domain found in target of myb protein 1 (Tom1) protein family

cd03565
Location:38 → 176

VHS_Tom1_like; VHS (Vps27/Hrs/STAM) domain of Tom1 subfamily