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ntfc-1 Cytosolic purine 5'-nucleotidase [ Caenorhabditis elegans ]

Gene ID: 180573, updated on 18-Sep-2024

Summary

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Official Symbol
ntfc-1
Official Full Name
Cytosolic purine 5'-nucleotidase
Primary source
WormBase:WBGene00022201
Locus tag
CELE_Y71H10B.1
See related
AllianceGenome:WB:WBGene00022201
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 5'-nucleotidase activity. Predicted to be involved in dephosphorylation. Is expressed in several structures, including anal depressor muscle; hypodermis; pharynx; reproductive system; and tail. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 45. Orthologous to several human genes including NT5C2 (5'-nucleotidase, cytosolic II). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (2834224..2840292, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Tetraspanin Neighboring gene ncRNA Neighboring gene Sperm-Specific family, class R Neighboring gene Serine/threonine-protein kinase kin-29 Neighboring gene Zinc finger protein tra-4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cytosolic purine 5'-nucleotidase
NP_001361936.1
  • Confirmed by transcript evidence
NP_001379633.1
  • Confirmed by transcript evidence
NP_508491.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    2834224..2840292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076090.9 → NP_508491.1  Cytosolic purine 5'-nucleotidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508491.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95X21
    Conserved Domains (1) summary
    pfam05761
    Location:24 → 459
    5_nucleotid; 5' nucleotidase family

  2. NM_001392738.1 → NP_001379633.1  Cytosolic purine 5'-nucleotidase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TZC8
    Conserved Domains (1) summary
    pfam05761
    Location:21 → 456
    5_nucleotid; 5' nucleotidase family

  3. NM_001374980.2 → NP_001361936.1  Cytosolic purine 5'-nucleotidase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86MI3
    Conserved Domains (1) summary
    pfam05761
    Location:1 → 428
    5_nucleotid; 5' nucleotidase family
Nucleotide Protein
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