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rfc-1 Replication factor C subunit 1 [ Caenorhabditis elegans ]

Gene ID: 179967, updated on 2-Nov-2024

Summary

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Official Symbol
rfc-1
Official Full Name
Replication factor C subunit 1
Primary source
WormBase:WBGene00004337
Locus tag
CELE_C54G10.2
See related
AllianceGenome:WB:WBGene00004337
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity. Predicted to be involved in DNA clamp unloading; DNA repair; and DNA replication. Predicted to be part of DNA replication factor C complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in West Nile fever and congenital heart disease. Orthologous to human RFC1 (replication factor C subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rfc-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (14642667..14645979, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CX domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ATP-binding cassette sub-family D member 4 Neighboring gene Mitochondrial carnitine/acylcarnitine carrier protein CACL Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MEL-28 is downstream of the Ran cycle and is required for nuclear-envelope function and chromatin maintenance. Fernandez AG, et al. Curr Biol, 2006 Sep 5. PMID 16950115
  2. Combined functional genomic maps of the C. elegans DNA damage response. Boulton SJ, et al. Science, 2002 Jan 4. PMID 11778048
  3. A targeted RNAi screen for genes involved in chromosome morphogenesis and nuclear organization in the Caenorhabditis elegans germline. Colaiácovo MP, et al. Genetics, 2002 Sep. PMID 12242227, Free PMC Article
  4. Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi. van Haaften G, et al. Curr Biol, 2006 Jul 11. PMID 16824923
  5. Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Pothof J, et al. Genes Dev, 2003 Feb 15. PMID 12600937, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA clamp unloading IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of DNA replication factor C complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Replication factor C subunit 1
NP_001256606.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    14642667..14645979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269677.2 → NP_001256606.1  Replication factor C subunit 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256606.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18841
    Conserved Domains (3) summary
    PRK04195
    Location:277 → 805
    PRK04195; replication factor C large subunit; Provisional
    pfam00004
    Location:344 → 453
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam08519
    Location:597 → 750
    RFC1; Replication factor RFC1 C terminal domain

RNA

  1. NR_069988.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

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