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F10C2.4 DNA polymerase delta catalytic subunit [ Caenorhabditis elegans ]

Gene ID: 179652, updated on 23-Nov-2023

Summary

Gene symbol
F10C2.4
Gene description
DNA polymerase delta catalytic subunit
Primary source
WormBase:WBGene00008645
Locus tag
CELE_F10C2.4
See related
AllianceGenome:WB:WBGene00008645
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 3'-5'-exodeoxyribonuclease activity and DNA-directed DNA polymerase activity. Predicted to be involved in DNA replication proofreading; base-excision repair, gap-filling; and nucleotide-excision repair, DNA gap filling. Predicted to be located in nucleus. Predicted to be part of delta DNA polymerase complex. Orthologous to human POLD1 (DNA polymerase delta 1, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See F10C2.4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (12041556..12045347)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Protein kup-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene alpha-1,2-Mannosidase Neighboring gene Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 3'-5'-DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication proofreading IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in base-excision repair, gap-filling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleotide-excision repair, DNA gap filling IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of DNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
part_of delta DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA polymerase delta catalytic subunit
NP_506017.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12041556..12045347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073616.4NP_506017.1  DNA polymerase delta catalytic subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506017.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90829
    Conserved Domains (4) summary
    cd05777
    Location:274503
    DNA_polB_delta_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase delta, a family-B DNA polymerase
    cd05533
    Location:551944
    POLBc_delta; DNA polymerase type-B delta subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. Presently, no direct data is available regarding ...
    PTZ00166
    Location:651072
    PTZ00166; DNA polymerase delta catalytic subunit; Provisional
    pfam14260
    Location:9811054
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta