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R04B5.5 [ Caenorhabditis elegans ]

Gene ID: 179405, updated on 11-Sep-2024

Summary

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Official Symbol
R04B5.5
Primary source
WormBase:WBGene00011003
Locus tag
CELE_R04B5.5
See related
AllianceGenome:WB:WBGene00011003
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable L-iditol 2-dehydrogenase activity. Predicted to be involved in sorbitol catabolic process. Is expressed in body wall musculature and intestine. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (10087480..10089002)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Nuclear hormone receptor family member nhr-12;Nuclear receptor Neighboring gene Sorbitol dehydrogenase Neighboring gene BHLH domain-containing protein Neighboring gene Transposase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables L-iditol 2-dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in sorbitol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sorbitol dehydrogenase
NP_505591.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10087480..10089002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073190.5 → NP_505591.1  Sorbitol dehydrogenase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505591.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21702
    Conserved Domains (1) summary
    cd05285
    Location:7 → 347
    sorbitol_DH; Sorbitol dehydrogenase
Nucleotide Protein
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