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Ppp1r12a protein phosphatase 1, regulatory subunit 12A [ Mus musculus (house mouse) ]

Gene ID: 17931, updated on 12-May-2024

Summary

Official Symbol
Ppp1r12aprovided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 12Aprovided by MGI
Primary source
MGI:MGI:1309528
See related
Ensembl:ENSMUSG00000019907 AllianceGenome:MGI:1309528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mypt1; D10Ertd625e; 1200015F06Rik; 5730577I22Rik
Summary
Predicted to enable several functions, including 14-3-3 protein binding activity; phosphatase regulator activity; and protein kinase binding activity. Acts upstream of or within cellular response to xenobiotic stimulus; protein dephosphorylation; and regulation of nucleocytoplasmic transport. Located in A band and Z disc. Is expressed in corpus striatum; genital tubercle epithelium; head mesenchyme; urethra epithelium; and urothelium. Orthologous to human PPP1R12A (protein phosphatase 1 regulatory subunit 12A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 144.2), CNS E11.5 (RPKM 14.0) and 11 other tissues See more
Orthologs
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Genomic context

See Ppp1r12a in Genome Data Viewer
Location:
10 D1; 10 56.33 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (107997913..108115846)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (108162092..108279985)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27787 Neighboring gene otogelin-like Neighboring gene predicted gene, 29685 Neighboring gene STARR-seq mESC enhancer starr_27789 Neighboring gene STARR-positive B cell enhancer ABC_E11458 Neighboring gene STARR-seq mESC enhancer starr_27796 Neighboring gene STARR-seq mESC enhancer starr_27797 Neighboring gene STARR-seq mESC enhancer starr_27798 Neighboring gene STARR-seq mESC enhancer starr_27807 Neighboring gene STARR-seq mESC enhancer starr_27810 Neighboring gene STARR-seq mESC enhancer starr_27812 Neighboring gene PRKC, apoptosis, WT1, regulator Neighboring gene predicted gene, 23105 Neighboring gene predicted gene, 36283 Neighboring gene predicted gene, 36440

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC159084

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in A band IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in A band IDA
Inferred from Direct Assay
more info
PubMed 
part_of PTW/PP1 phosphatase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in contractile muscle fiber ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 12A
Names
myosin phosphatase target subunit 1
myosin phosphatase-targeting subunit 1
protein phosphatase 1, regulatory (inhibitor) subunit 12A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368736.1NP_001355665.1  protein phosphatase 1 regulatory subunit 12A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC139335
    Consensus CDS
    CCDS88083.1
    UniProtKB/Swiss-Prot
    Q05A74, Q8CBV2, Q99NB6, Q9DBR7
    Related
    ENSMUSP00000151842.2, ENSMUST00000219263.2
    Conserved Domains (4) summary
    PHA03095
    Location:43272
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:9301028
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
  2. NM_001368737.1NP_001355666.1  protein phosphatase 1 regulatory subunit 12A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC139335
    Conserved Domains (4) summary
    PHA03095
    Location:43272
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:874972
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
  3. NM_027892.3NP_082168.1  protein phosphatase 1 regulatory subunit 12A isoform 2

    See identical proteins and their annotated locations for NP_082168.1

    Status: VALIDATED

    Source sequence(s)
    AC139335
    Consensus CDS
    CCDS36052.1
    UniProtKB/Swiss-Prot
    Q9DBR7
    Related
    ENSMUSP00000069257.6, ENSMUST00000070663.6
    Conserved Domains (5) summary
    cd00204
    Location:67252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199252
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:930984
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    107997913..108115846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513329.5XP_006513392.1  protein phosphatase 1 regulatory subunit 12A isoform X2

    See identical proteins and their annotated locations for XP_006513392.1

    Conserved Domains (3) summary
    PHA03095
    Location:43272
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
    pfam15898
    Location:873971
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
  2. XM_006513327.5XP_006513390.1  protein phosphatase 1 regulatory subunit 12A isoform X1

    Conserved Domains (3) summary
    PHA03095
    Location:43272
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
    pfam15898
    Location:930984
    PRKG1_interact; cGMP-dependent protein kinase interacting domain