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PPP1R12A protein phosphatase 1 regulatory subunit 12A [ Homo sapiens (human) ]

Gene ID: 4659, updated on 8-Oct-2017
Official Symbol
PPP1R12Aprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 12Aprovided by HGNC
Primary source
HGNC:HGNC:7618
See related
Ensembl:ENSG00000058272 MIM:602021; Vega:OTTHUMG00000170100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MBS; M130; MYPT1
Summary
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Orthologs
Location:
12q21.2-q21.31
Exon count:
31
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (79773563..79935455, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (80167343..80329235, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NOP56 ribonucleoprotein pseudogene 3 Neighboring gene pro-apoptotic WT1 regulator Neighboring gene uncharacterized LOC105369864 Neighboring gene RNA, 5S ribosomal pseudogene 363 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 20 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 20

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat Treatment of human brain endothelial cells with Tat markedly elevate GTP-RhoA levels and the potential downstream effectors, such as myosin phosphatase target subunit 1 and myosin light chain PubMed
nucleocapsid gag HIV-1 NC is identified to have a physical interaction with protein phosphatase 1, regulatory subunit 12A (PPP1R12A; YMPT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • G2/M Transition, organism-specific biosystem (from REACTOME)
    G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
  • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
    Mitotic G2-G2/M phases, organism-specific biosystem
    Mitotic G2-G2/M phases
  • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
    Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
    Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    PLK1 signaling events, organism-specific biosystem
    PLK1 signaling events
  • Platelet activation, organism-specific biosystem (from KEGG)
    Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate ROCKs, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate ROCKs, organism-specific biosystemRHO associated, coiled-coil containing protein kinases ROCK1 and ROCK2 consist of a serine/threonine kinase domain, a coiled-coil region, a RHO-binding domain and a plekstrin homology (PH) domain int...
  • RHO GTPases activate PAKs, organism-specific biosystem (from REACTOME)
    RHO GTPases activate PAKs, organism-specific biosystemThe PAKs (p21-activated kinases) are a family of serine/threonine kinases mainly implicated in cytoskeletal rearrangements. All PAKs share a conserved catalytic domain located at the carboxyl terminu...
  • RHO GTPases activate PKNs, organism-specific biosystem (from REACTOME)
    RHO GTPases activate PKNs, organism-specific biosystemProtein kinases N (PKN), also known as protein kinase C-related kinases (PKR) feature a C-terminal serine/threonine kinase domain and three RHO-binding motifs at the N-terminus. RHO GTPases RHOA, RHO...
  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
  • Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystem (from REACTOME)
    Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystemThe kinase activity of PLK1 is required for cell cycle progression as PLK1 phosphorylates and regulates a number of cellular proteins during mitosis. Centrosomic AURKA (Aurora A kinase), catalyticall...
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • RhoA signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    RhoA signaling pathway, organism-specific biosystem
    RhoA signaling pathway
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
    Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
    Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC133042

Gene Ontology Provided by GOA

Function Evidence Code Pubs
14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
signal transducer activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of catalytic activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of myosin-light-chain-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
NOT regulation of establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of myosin-light-chain-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
A band ISS
Inferred from Sequence or Structural Similarity
more info
 
PTW/PP1 phosphatase complex IDA
Inferred from Direct Assay
more info
PubMed 
Z disc ISS
Inferred from Sequence or Structural Similarity
more info
 
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
contractile fiber IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
protein phosphatase 1 regulatory subunit 12A
Names
myosin binding subunit
myosin phosphatase, target subunit 1
myosin phosphatase-targeting subunit 1
protein phosphatase 1, regulatory (inhibitor) subunit 12A
protein phosphatase myosin-binding subunit

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143885.1NP_001137357.1  protein phosphatase 1 regulatory subunit 12A isoform a

    See identical proteins and their annotated locations for NP_001137357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AC073569, AF458589, AK314193, BC111752
    Consensus CDS
    CCDS44947.1
    UniProtKB/Swiss-Prot
    O14974
    UniProtKB/TrEMBL
    B2RAH5
    Related
    ENSP00000261207.5, ENST00000261207.9
    Conserved Domains (5) summary
    cd00204
    Location:67252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199252
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:9311029
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
  2. NM_001143886.1NP_001137358.1  protein phosphatase 1 regulatory subunit 12A isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC073569, AK302692, BC111752
    Consensus CDS
    CCDS44948.1
    UniProtKB/Swiss-Prot
    O14974
    Related
    ENSP00000449514.1, OTTHUMP00000242814, ENST00000546369.5, OTTHUMT00000407256
    Conserved Domains (5) summary
    cd00204
    Location:13165
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:112165
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:558
    Ank_5; Ankyrin repeats (many copies)
    pfam15898
    Location:844942
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:1849
    ANK; ANK repeat [structural motif]
  3. NM_001244990.1NP_001231919.1  protein phosphatase 1 regulatory subunit 12A isoform c

    See identical proteins and their annotated locations for NP_001231919.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC018476, AC073569, AC074270
    Consensus CDS
    CCDS58260.1
    UniProtKB/Swiss-Prot
    O14974
    Related
    ENSP00000416769.2, OTTHUMP00000242813, ENST00000437004.6, OTTHUMT00000407255
    Conserved Domains (5) summary
    cd00204
    Location:67252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199252
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:933994
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
  4. NM_001244992.1NP_001231921.1  protein phosphatase 1 regulatory subunit 12A isoform d

    See identical proteins and their annotated locations for NP_001231921.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an exon in the coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC018476, AC073569, AC074270
    Consensus CDS
    CCDS58259.1
    UniProtKB/Swiss-Prot
    O14974
    Related
    ENSP00000446855.1, OTTHUMP00000242815, ENST00000550107.5, OTTHUMT00000407257
    Conserved Domains (5) summary
    cd00204
    Location:67252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199252
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:875973
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
  5. NM_002480.2NP_002471.1  protein phosphatase 1 regulatory subunit 12A isoform a

    See identical proteins and their annotated locations for NP_002471.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AC073569, AK314193, BC111752, DC350703
    Consensus CDS
    CCDS44947.1
    UniProtKB/Swiss-Prot
    O14974
    UniProtKB/TrEMBL
    B2RAH5
    Related
    ENSP00000389168.2, OTTHUMP00000242812, ENST00000450142.6, OTTHUMT00000407254
    Conserved Domains (5) summary
    cd00204
    Location:67252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199252
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:9311029
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

    Range
    79773563..79935455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019328.1XP_016874817.1  protein phosphatase 1 regulatory subunit 12A isoform X16

  2. XM_017019325.1XP_016874814.1  protein phosphatase 1 regulatory subunit 12A isoform X11

  3. XM_017019329.1XP_016874818.1  protein phosphatase 1 regulatory subunit 12A isoform X17

  4. XM_017019324.1XP_016874813.1  protein phosphatase 1 regulatory subunit 12A isoform X10

  5. XM_011538377.1XP_011536679.1  protein phosphatase 1 regulatory subunit 12A isoform X4

    Conserved Domains (5) summary
    cd00204
    Location:67252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199252
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:9451043
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
  6. XM_011538385.1XP_011536687.1  protein phosphatase 1 regulatory subunit 12A isoform X19

    Conserved Domains (5) summary
    cd00204
    Location:67252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199252
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:816914
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
  7. XM_017019326.1XP_016874815.1  protein phosphatase 1 regulatory subunit 12A isoform X13

  8. XM_017019323.1XP_016874812.1  protein phosphatase 1 regulatory subunit 12A isoform X6

  9. XM_011538383.2XP_011536685.1  protein phosphatase 1 regulatory subunit 12A isoform X12

    UniProtKB/Swiss-Prot
    O14974
    Conserved Domains (5) summary
    cd00204
    Location:67252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199252
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:872970
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
  10. XM_011538384.1XP_011536686.1  protein phosphatase 1 regulatory subunit 12A isoform X14

    Conserved Domains (5) summary
    cd00204
    Location:67252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199252
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:855953
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
  11. XM_011538379.1XP_011536681.1  protein phosphatase 1 regulatory subunit 12A isoform X7

    Conserved Domains (5) summary
    cd00204
    Location:67252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199252
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:9141012
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
  12. XM_011538375.1XP_011536677.1  protein phosphatase 1 regulatory subunit 12A isoform X2

    Conserved Domains (5) summary
    cd00204
    Location:67252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199252
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:9581056
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
  13. XM_011538380.1XP_011536682.1  protein phosphatase 1 regulatory subunit 12A isoform X8

    Conserved Domains (5) summary
    cd00204
    Location:67252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199252
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:9111009
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
  14. XM_011538374.1XP_011536676.1  protein phosphatase 1 regulatory subunit 12A isoform X1

    Conserved Domains (5) summary
    cd00204
    Location:67252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199252
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:9701068
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
  15. XM_005268887.3XP_005268944.1  protein phosphatase 1 regulatory subunit 12A isoform X9

    Conserved Domains (5) summary
    cd00204
    Location:67252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199252
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:931985
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
  16. XM_017019327.1XP_016874816.1  protein phosphatase 1 regulatory subunit 12A isoform X15

  17. XM_011538378.2XP_011536680.1  protein phosphatase 1 regulatory subunit 12A isoform X5

    Conserved Domains (5) summary
    cd00204
    Location:67252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199252
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:9701024
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
  18. XM_011538376.2XP_011536678.1  protein phosphatase 1 regulatory subunit 12A isoform X3

    Conserved Domains (5) summary
    cd00204
    Location:67252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47136
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:199252
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:9701024
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72103
    ANK; ANK repeat [structural motif]
  19. XM_017019330.1XP_016874819.1  protein phosphatase 1 regulatory subunit 12A isoform X18

RNA

  1. XR_001748712.1 RNA Sequence

  2. XR_001748713.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    80133789..80295575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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