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Myl1 myosin, light polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 17901, updated on 2-Nov-2024

Summary

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Official Symbol
Myl1provided by MGI
Official Full Name
myosin, light polypeptide 1provided by MGI
Primary source
MGI:MGI:97269
See related
Ensembl:ENSMUSG00000061816 AllianceGenome:MGI:97269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mylf; MLC1f; MLC3f
Summary
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two non-phosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in mammary gland adult (RPKM 118.5), limb E14.5 (RPKM 25.3) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Myl1 in Genome Data Viewer
Location:
1 C3; 1 33.71 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (66963454..66987091, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (66924295..66947932, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene acyl-Coenzyme A dehydrogenase, long-chain Neighboring gene predicted gene, 27934 Neighboring gene predicted gene, 25832 Neighboring gene STARR-seq mESC enhancer starr_01192 Neighboring gene ribosomal protein L31, pseudogene 14 Neighboring gene histidyl-tRNA synthetase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Selective expression of Cre recombinase in skeletal muscle fibers. Bothe GW, et al. Genesis, 2000 Feb. PMID 10686620
  2. Comparative Analysis of Muscle Hypertrophy Models Reveals Divergent Gene Transcription Profiles and Points to Translational Regulation of Muscle Growth through Increased mTOR Signaling. Pereira MG, et al. Front Physiol, 2017. PMID 29255421, Free PMC Article
  3. cDNA recombinant plasmid complementary to mRNAs for light chains 1 and 3 of mouse skeletal muscle myosin. Robert B, et al. Proc Natl Acad Sci U S A, 1982 Apr. PMID 6283523, Free PMC Article
  4. Inducible activation of Akt increases skeletal muscle mass and force without satellite cell activation. Blaauw B, et al. FASEB J, 2009 Nov. PMID 19661286
  5. Regulation of cell proliferation by fast Myosin light chain 1 in myoblasts derived from extraocular muscle, diaphragm and gastrocnemius. Zhang SZ, et al. Exp Biol Med (Maywood), 2008 Nov. PMID 18957633

See all (212) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. aPKCzeta is required for the cellular organization of acto-non-muscle myosin II (NMII) cytoskeleton, for proper cell adhesion and directed cell migration.
    Title: aPKCζ affects directed cell migration through the regulation of myosin light chain phosphorylation.
  2. This study provides an additional mechanistic link between Angiotensin II and vasoconstriction via SFK-enhanced MLC phosphorylation in smooth muscle cells.
    Title: Src Family Kinases (SFK) Mediate Angiotensin II-Induced Myosin Light Chain Phosphorylation and Hypertension.
  3. Data show that Ca(V) 1.2 and 1.3 channels are expressed in lens, regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins 50 and 46.
    Title: L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins.
  4. Results show that the binding force between selenium and cardiac myosin (CM), which consists of two heavy chains (MHC) and two pairs of light chains: MLC1 and MLC2, was 100 times stronger than that of daunorubicin (DNR) and CM.
    Title: Effect of selenium on the interaction between daunorubicin and cardiac myosin.
  5. The present work further established the role of MuRF1 in muscle atrophy and for the first time shows that MuRF1 plays a role in muscle fatigue and twitch potentiation.
    Title: Modulation of muscle atrophy, fatigue and MLC phosphorylation by MuRF1 as indicated by hindlimb suspension studies on MuRF1-KO mice.
  6. MLC1f expression is reversely related to the proliferation of muscle cells.
    Title: Regulation of cell proliferation by fast Myosin light chain 1 in myoblasts derived from extraocular muscle, diaphragm and gastrocnemius.
  7. Using double reporter transgenes study demonstrates that each enhancer can activate both Mlc1f and Mlc3f promoters in vivo, revealing enhancer sharing rather than exclusive enhancer-promoter interactions.
    Title: Integration of embryonic and fetal skeletal myogenic programs at the myosin light chain 1f/3f locus.
  8. Targeted deletion of the MLC1f/3 downstream enhancer results in precocious MLC expression and mesoderm ablation. This suggests that the enhancer and its flanking sequences in clude negative regulatory elements as well as positive ones.
    Title: Targeted deletion of the MLC1f/3f downstream enhancer results in precocious MLC expression and mesoderm ablation.
  9. myotome pairs are transiently left-right asymmetric, with higher expression of alpha-skeletal actin and myosin light chain 3F (MLC3F) on the left side between embryonic day 9.5-10.25.
    Title: Mouse myotomes pairs exhibit left-right asymmetric expression of MLC3F and alpha-skeletal actin.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of muscle ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of muscle ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle contraction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in contractile muscle fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in contractile muscle fiber ISO
Inferred from Sequence Orthology
more info
  
located_in myofibril IEA
Inferred from Electronic Annotation
more info
  
located_in myofibril ISO
Inferred from Sequence Orthology
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin light chain 1/3, skeletal muscle isoform
Names
A1 catalytic
A2 catalytic
MLC1/MLC3
MLC1F/MLC3F
myosin light chain A1/A2
myosin light chain alkali 1/2
myosin light chain, alkali, fast skeletal muscle
myosin, light polypeptide 1, alkali; atrial, embryonic
myosin, light polypeptide 4, alkali; atrial, embryonic

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113387.2 → NP_001106858.1  myosin light chain 1/3, skeletal muscle isoform isoform 3f

    See identical proteins and their annotated locations for NP_001106858.1

    Status: VALIDATED

    Source sequence(s)
    AC124389
    Consensus CDS
    CCDS48284.1
    UniProtKB/TrEMBL
    Q545G5, Q6PCW9
    Related
    ENSMUSP00000112861.2, ENSMUST00000119429.8
    Conserved Domains (1) summary
    PTZ00184
    Location:4 → 149
    PTZ00184; calmodulin; Provisional

  2. NM_001420333.1 → NP_001407262.1  myosin light chain 1/3, skeletal muscle isoform isoform 1f

    Status: VALIDATED

    Source sequence(s)
    AC124389, AC133187
    UniProtKB/Swiss-Prot
    P05977, P05978
    UniProtKB/TrEMBL
    Q545T7

  3. NM_001420334.1 → NP_001407263.1  myosin light chain 1/3, skeletal muscle isoform isoform 3f

    Status: VALIDATED

    Source sequence(s)
    AC124389
    UniProtKB/TrEMBL
    Q545G5

  4. NM_021285.4 → NP_067260.1  myosin light chain 1/3, skeletal muscle isoform isoform 1f

    See identical proteins and their annotated locations for NP_067260.1

    Status: VALIDATED

    Source sequence(s)
    AC124389, AC133187
    Consensus CDS
    CCDS15024.1
    UniProtKB/Swiss-Prot
    P05977, P05978
    UniProtKB/TrEMBL
    Q545T7
    Related
    ENSMUSP00000027151.6, ENSMUST00000027151.12
    Conserved Domains (1) summary
    PTZ00184
    Location:39 → 187
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    66963454..66987091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162616.1 → XP_036018509.1  myosin light chain 1/3, skeletal muscle isoform isoform X1

    UniProtKB/Swiss-Prot
    P05977, P05978
    UniProtKB/TrEMBL
    Q545T7
    Conserved Domains (1) summary
    PTZ00184
    Location:39 → 187
    PTZ00184; calmodulin; Provisional

  2. XM_036162618.1 → XP_036018511.1  myosin light chain 1/3, skeletal muscle isoform isoform X1

    UniProtKB/Swiss-Prot
    P05977, P05978
    UniProtKB/TrEMBL
    Q545T7
    Conserved Domains (1) summary
    PTZ00184
    Location:39 → 187
    PTZ00184; calmodulin; Provisional

  3. XM_011238451.4 → XP_011236753.1  myosin light chain 1/3, skeletal muscle isoform isoform X2

    UniProtKB/TrEMBL
    E9PWG4, Q6PCW9
    Related
    ENSMUSP00000112880.2, ENSMUST00000120415.8
    Conserved Domains (1) summary
    PTZ00184
    Location:4 → 141
    PTZ00184; calmodulin; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05977.2 GenPept UniProtKB/Swiss-Prot:P05977

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