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Myl1 myosin, light polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 17901, updated on 17-Jan-2023

Summary

Official Symbol
Myl1provided by MGI
Official Full Name
myosin, light polypeptide 1provided by MGI
Primary source
MGI:MGI:97269
See related
Ensembl:ENSMUSG00000061816 AllianceGenome:MGI:97269
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mylf; MLC1f; MLC3f
Summary
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two non-phosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in mammary gland adult (RPKM 118.5), limb E14.5 (RPKM 25.3) and 3 other tissues See more
Orthologs
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Genomic context

See Myl1 in Genome Data Viewer
Location:
1 C3; 1 33.71 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (66963454..66987091, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (66924295..66947932, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene acyl-Coenzyme A dehydrogenase, long-chain Neighboring gene predicted gene, 27934 Neighboring gene predicted gene, 25832 Neighboring gene ribosomal protein L31, pseudogene 14 Neighboring gene histidyl-tRNA synthetase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of muscle ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in muscle contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in contractile fiber IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in contractile fiber ISO
Inferred from Sequence Orthology
more info
 
located_in myofibril ISO
Inferred from Sequence Orthology
more info
 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myosin light chain 1/3, skeletal muscle isoform
Names
A1 catalytic
A2 catalytic
MLC1/MLC3
MLC1F/MLC3F
myosin light chain A1/A2
myosin light chain alkali 1/2
myosin light chain, alkali, fast skeletal muscle
myosin, light polypeptide 1, alkali; atrial, embryonic
myosin, light polypeptide 4, alkali; atrial, embryonic

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113387.1NP_001106858.1  myosin light chain 1/3, skeletal muscle isoform isoform 3f

    See identical proteins and their annotated locations for NP_001106858.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3f) encodes a protein that is 38 aa shorter than isoform 1f. Transcript variants 3f and 1f differ in their first two exons.
    Source sequence(s)
    AK009938, BY785713, W48198
    Consensus CDS
    CCDS48284.1
    UniProtKB/Swiss-Prot
    P05977
    UniProtKB/TrEMBL
    A0A6P5Q030, Q545G5
    Related
    ENSMUSP00000112861.2, ENSMUST00000119429.8
    Conserved Domains (1) summary
    PTZ00184
    Location:4149
    PTZ00184; calmodulin; Provisional
  2. NM_021285.3NP_067260.1  myosin light chain 1/3, skeletal muscle isoform isoform 1f

    See identical proteins and their annotated locations for NP_067260.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1f) encodes a protein that is 38 aa longer than isoform 3f. Transcript variants 1f and 3f differ in their first two exons.
    Source sequence(s)
    AK003182, W48198, W87050
    Consensus CDS
    CCDS15024.1
    UniProtKB/Swiss-Prot
    P05977, P05978
    UniProtKB/TrEMBL
    A0A6P5Q4Q5, A0A8C6GD50, Q545T7
    Related
    ENSMUSP00000027151.6, ENSMUST00000027151.12
    Conserved Domains (1) summary
    PTZ00184
    Location:39187
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    66963454..66987091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162616.1XP_036018509.1  myosin light chain 1/3, skeletal muscle isoform isoform X1

    UniProtKB/Swiss-Prot
    P05978
    UniProtKB/TrEMBL
    A0A6P5Q4Q5, A0A8C6GD50, Q545T7
    Conserved Domains (1) summary
    PTZ00184
    Location:39187
    PTZ00184; calmodulin; Provisional
  2. XM_036162618.1XP_036018511.1  myosin light chain 1/3, skeletal muscle isoform isoform X1

    UniProtKB/Swiss-Prot
    P05978
    UniProtKB/TrEMBL
    A0A6P5Q4Q5, A0A8C6GD50, Q545T7
    Conserved Domains (1) summary
    PTZ00184
    Location:39187
    PTZ00184; calmodulin; Provisional
  3. XM_036162620.1XP_036018513.1  myosin light chain 1/3, skeletal muscle isoform isoform X3

    UniProtKB/TrEMBL
    A0A6P5Q030, Q545G5
    Conserved Domains (1) summary
    PTZ00184
    Location:4149
    PTZ00184; calmodulin; Provisional
  4. XM_011238451.4XP_011236753.1  myosin light chain 1/3, skeletal muscle isoform isoform X2

    UniProtKB/TrEMBL
    A0A8C6GCV2, E9PWG4
    Related
    ENSMUSP00000112880.2, ENSMUST00000120415.8
    Conserved Domains (1) summary
    PTZ00184
    Location:4141
    PTZ00184; calmodulin; Provisional