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hpo-18 ATP synthase subunit epsilon, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 178830, updated on 25-Apr-2024

Summary

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Gene symbol
hpo-18
Gene description
ATP synthase subunit epsilon, mitochondrial
Primary source
WormBase:WBGene00017982
Locus tag
CELE_F32D1.2
See related
AllianceGenome:WB:WBGene00017982
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in mitochondrial ATP synthesis coupled proton transport. Predicted to be part of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1). Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 3. Orthologous to human ATP5F1E (ATP synthase F1 subunit epsilon) and ATP5F1EP2 (ATP synthase F1 subunit epsilon pseudogene 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
2
Sequence:
Chromosome: V; NC_003283.11 (4346089..4346425, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Recep_L_domain domain-containing protein;Receptor L-domain domain-containing protein Neighboring gene Glutaredoxin 3 Neighboring gene AAA domain-containing protein;Fidgetin-like protein 1;Spastin/Vps4 C-terminal domain-containing protein Neighboring gene DNA replication licensing factor MCM7 Neighboring gene TPR_REGION domain-containing protein;dolichyl-phosphate-mannose--protein mannosyltransferase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATP synthase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cellular anatomical entity IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP synthase subunit epsilon, mitochondrial
NP_504198.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    4346089..4346425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071797.8 → NP_504198.1  ATP synthase subunit epsilon, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504198.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16298
    Conserved Domains (1) summary
    pfam04627
    Location:3 → 50
    ATP-synt_Eps; Mitochondrial ATP synthase epsilon chain
Nucleotide Protein
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