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ilcr-1 Interleukin cytokine receptor-related protein 1 [ Caenorhabditis elegans ]

Gene ID: 178376, updated on 18-Sep-2024

Summary

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Official Symbol
ilcr-1
Official Full Name
Interleukin cytokine receptor-related protein 1
Primary source
WormBase:WBGene00013415
Locus tag
CELE_Y64G10A.6
See related
AllianceGenome:WB:WBGene00013415
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable interleukin-17 receptor activity. Involved in positive regulation of locomotion and response to oxygen levels. Located in plasma membrane. Part of receptor complex. Is expressed in neurons. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis; hypogonadotropic hypogonadism 18 with or without anosmia; and immunodeficiency 51. Orthologous to several human genes including IL17RA (interleukin 17 receptor A); IL17RB (interleukin 17 receptor B); and IL17RC (interleukin 17 receptor C). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
11
Sequence:
Chromosome: IV; NC_003282.8 (14276460..14285527)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. IL-17: good fear no tears. Rua R, et al. Nat Immunol, 2020 Nov. PMID 32958929
  2. IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. Chen C, et al. Nature, 2017 Feb 2. PMID 28099418, Free PMC Article
  3. MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity. Flynn SM, et al. Nat Commun, 2020 Apr 29. PMID 32350248, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables interleukin-17 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-17 receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxygen levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Interleukin cytokine receptor-related protein 1
NP_502736.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    14276460..14285527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070335.6 → NP_502736.1  Interleukin cytokine receptor-related protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502736.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NA64
    Conserved Domains (1) summary
    cl23749
    Location:479 → 620
    TIR_2; TIR domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NA64.1

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