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DYNC1I1 dynein cytoplasmic 1 intermediate chain 1 [ Homo sapiens (human) ]

Gene ID: 1780, updated on 1-Aug-2020

Summary

Official Symbol
DYNC1I1provided by HGNC
Official Full Name
dynein cytoplasmic 1 intermediate chain 1provided by HGNC
Primary source
HGNC:HGNC:2963
See related
Ensembl:ENSG00000158560 MIM:603772
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DNCI1; DNCIC1
Expression
Biased expression in brain (RPKM 14.7), adrenal (RPKM 3.3) and 4 other tissues See more
Orthologs

Genomic context

See DYNC1I1 in Genome Data Viewer
Location:
7q21.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (95772506..96110322)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (95401818..95739634)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986746 Neighboring gene uncharacterized LOC105375409 Neighboring gene eDlx#27 enhancer in SHFM1 region Neighboring gene eDlx#26 enhancer in SHFM1 region Neighboring gene eDlx#24 enhancer in SHFM1 region Neighboring gene eExon 15 DLX5/6 limb enhancer Neighboring gene eExon 17 DLX5/6 limb enhancer Neighboring gene eDlx#23 enhancer in SHFM1 region Neighboring gene solute carrier family 25 member 13 Neighboring gene CYCS pseudogene 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag HIV-1 CA uncoating is delayed in the presence of ciliobrevin D, a specific inhibitor of dynein-mediated motor function, indicating that dynein is involved in CA uncoating in cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule motor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
motor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
spectrin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle transport along microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic dynein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytoplasmic dynein 1 intermediate chain 1
Names
DH IC-1
cytoplasmic dynein intermediate chain 1
dynein intermediate chain 1, cytosolic
dynein, cytoplasmic, intermediate polypeptide 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135556.1NP_001129028.1  cytoplasmic dynein 1 intermediate chain 1 isoform b

    See identical proteins and their annotated locations for NP_001129028.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF123074, AK313148, BC032945, DA491512, DB343806
    Consensus CDS
    CCDS47645.1
    UniProtKB/Swiss-Prot
    O14576
    UniProtKB/TrEMBL
    A4D1I7, Q8N542
    Related
    ENSP00000392337.2, ENST00000447467.6
    Conserved Domains (3) summary
    sd00039
    Location:329368
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:130156
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    cl25539
    Location:266589
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001135557.1NP_001129029.1  cytoplasmic dynein 1 intermediate chain 1 isoform c

    See identical proteins and their annotated locations for NP_001129029.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF123074, BC032945, DA491512, DB343806
    Consensus CDS
    CCDS47646.1
    UniProtKB/Swiss-Prot
    O14576
    UniProtKB/TrEMBL
    Q8N542
    Related
    ENSP00000352348.4, ENST00000359388.8
    Conserved Domains (3) summary
    sd00039
    Location:309348
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:110136
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    cl25539
    Location:246569
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001278421.1NP_001265350.1  cytoplasmic dynein 1 intermediate chain 1 isoform d

    See identical proteins and their annotated locations for NP_001265350.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK309419, BC022540, BC032945, DA491512
    Consensus CDS
    CCDS64718.1
    UniProtKB/Swiss-Prot
    O14576
    UniProtKB/TrEMBL
    Q8N542
    Related
    ENSP00000398118.1, ENST00000437599.5
    Conserved Domains (3) summary
    sd00039
    Location:326365
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:127153
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    cl25539
    Location:263586
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_001278422.1NP_001265351.1  cytoplasmic dynein 1 intermediate chain 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice junction at the 5' end of an exon, lacks an alternate in-frame exon, and has an alternate 3'-most exon compared to variant 1. The resulting isoform (e) lacks two alternate segments in the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC002452, AK297427, DA491512
    Consensus CDS
    CCDS64719.1
    UniProtKB/Swiss-Prot
    O14576
    Related
    ENSP00000486363.1, ENST00000630942.2
    Conserved Domains (4) summary
    COG2319
    Location:160570
    WD40; WD40 repeat [General function prediction only]
    pfam11540
    Location:110136
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    sd00039
    Location:309348
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:246569
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. NM_004411.4NP_004402.1  cytoplasmic dynein 1 intermediate chain 1 isoform a

    See identical proteins and their annotated locations for NP_004402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK313148, BC032945, BP307571, DA491512, DB343806
    Consensus CDS
    CCDS5644.1
    UniProtKB/Swiss-Prot
    O14576
    UniProtKB/TrEMBL
    A4D1I7, Q8N542
    Related
    ENSP00000320130.6, ENST00000324972.10
    Conserved Domains (3) summary
    sd00039
    Location:346385
    7WD40; WD40 repeat [structural motif]
    pfam11540
    Location:147173
    Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
    cl25539
    Location:283606
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    95772506..96110322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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