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Tesmin testis expressed metallothionein like [ Mus musculus (house mouse) ]

Gene ID: 17771, updated on 2-Nov-2024

Summary

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Official Symbol
Tesminprovided by MGI
Official Full Name
testis expressed metallothionein likeprovided by MGI
Primary source
MGI:MGI:1340029
See related
Ensembl:ENSMUSG00000024905 AllianceGenome:MGI:1340029
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mtl5
Summary
Involved in male meiotic nuclear division and spermatogenesis. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including adrenal gland; gonad; heart; liver; and lung. Orthologous to human TESMIN (testis expressed metallothionein like protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 35.1) See more
Orthologs
human all
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Genomic context

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See Tesmin in Genome Data Viewer
Location:
19 A; 19 3.15 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (3438857..3457823)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (3388857..3407823)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L21 Neighboring gene microRNA 6984 Neighboring gene STARR-seq mESC enhancer starr_45314 Neighboring gene carnitine palmitoyltransferase 1a, liver Neighboring gene galanin and GMAP prepropeptide Neighboring gene STARR-seq mESC enhancer starr_45317 Neighboring gene protein phosphatase 6, regulatory subunit 3 Neighboring gene predicted gene, 23940

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proximity-dependent biotin labeling in testicular germ cells identified TESMIN-associated proteins. Oura S, et al. Sci Rep, 2022 Dec 23. PMID 36564444, Free PMC Article
  2. Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice†. Oji A, et al. Biol Reprod, 2020 Apr 15. PMID 31916570, Free PMC Article
  3. Metallothionein-like 5 expression is correlated with poor prognosis and promotes proliferation of cervical squamous cell carcinoma. Huang Y, et al. Bioengineered, 2022 Mar. PMID 35249447, Free PMC Article
  4. A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. Sugihara T, et al. Genomics, 1999 Apr 1. PMID 10191092
  5. Germ cell-specific nucleocytoplasmic shuttling protein, tesmin, responsive to heavy metal stress in mouse testes. Matsuura T, et al. J Inorg Biochem, 2002 Jan 15. PMID 11803038

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Metallothionein-like 5 expression is correlated with poor prognosis and promotes proliferation of cervical squamous cell carcinoma.
    Title: Metallothionein-like 5 expression is correlated with poor prognosis and promotes proliferation of cervical squamous cell carcinoma.
  2. Nuclear translocation of MTL5 from cytoplasm requires its direct interaction with LIN9 and is essential for male meiosis and fertility.
    Title: Nuclear translocation of MTL5 from cytoplasm requires its direct interaction with LIN9 and is essential for male meiosis and fertility.
  3. Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Micedagger.
    Title: Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice†.
  4. regulation of the tesmin nucleocytoplasmic shuttling by the effect of metal stress
    Title: Germ cell-specific nucleocytoplasmic shuttling protein, tesmin, responsive to heavy metal stress in mouse testes.
  5. Data suggest that tesmin transcription may be controlled by two different mechanisms during male and female meiosis.
    Title: Tesmin transcription is regulated differently during male and female meiosis.
  6. tesmin is involved in multiple stages of spermatogenesis and spermiogenesis
    Title: Native tesmin is a 60-kilodalton protein that undergoes dynamic changes in its localization during spermatogenesis in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tesmin
Names
metallothionein-like 5, testis-specific (tesmin)
testis-specific metallothionein-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039657.2 → NP_001034746.1  tesmin isoform a

    See identical proteins and their annotated locations for NP_001034746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK015724, AK015732, AK161511
    Consensus CDS
    CCDS37880.1
    UniProtKB/Swiss-Prot
    Q548K4, Q8VIE0, Q8VIE1, Q9WTJ6
    Related
    ENSMUSP00000025840.10, ENSMUST00000025840.16
    Conserved Domains (1) summary
    pfam03638
    Location:334 → 371
    TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

  2. NM_001039658.2 → NP_001034747.1  tesmin isoform b

    See identical proteins and their annotated locations for NP_001034747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK015732, AK161511
    Consensus CDS
    CCDS50339.1
    UniProtKB/TrEMBL
    Q9D571
    Related
    ENSMUSP00000114142.2, ENSMUST00000151341.8

  3. NM_001286557.1 → NP_001273486.1  tesmin isoform c

    See identical proteins and their annotated locations for NP_001273486.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.
    Source sequence(s)
    AK015724, AK161511, AL626765
    Consensus CDS
    CCDS70912.1
    UniProtKB/Swiss-Prot
    Q9WTJ6
    Related
    ENSMUSP00000114171.2, ENSMUST00000142193.8
    Conserved Domains (1) summary
    pfam03638
    Location:154 → 191
    TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

  4. NM_001286558.1 → NP_001273487.1  tesmin isoform c

    See identical proteins and their annotated locations for NP_001273487.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.
    Source sequence(s)
    AK015724, AK161511, AL626765
    Consensus CDS
    CCDS70912.1
    UniProtKB/Swiss-Prot
    Q9WTJ6
    Related
    ENSMUSP00000122687.2, ENSMUST00000127142.2
    Conserved Domains (1) summary
    pfam03638
    Location:154 → 191
    TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    3438857..3457823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_010841.1: Suppressed sequence

    Description
    NM_010841.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTJ6.2 GenPept UniProtKB/Swiss-Prot:Q9WTJ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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