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TESMIN testis expressed metallothionein like protein [ Homo sapiens (human) ]

Gene ID: 9633, updated on 13-Mar-2020

Summary

Official Symbol
TESMINprovided by HGNC
Official Full Name
testis expressed metallothionein like proteinprovided by HGNC
Primary source
HGNC:HGNC:7446
See related
Ensembl:ENSG00000132749 MIM:604374
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTL5; MTLT; CXCDC2
Summary
Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 13.9), bone marrow (RPKM 1.4) and 2 other tissues See more
Orthologs

Genomic context

See TESMIN in Genome Data Viewer
Location:
11q13.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (68706674..68751564, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (68474908..68518988, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984343 Neighboring gene Sharpr-MPRA regulatory region 1260 Neighboring gene galanin and GMAP prepropeptide Neighboring gene carnitine palmitoyltransferase 1A Neighboring gene long intergenic non-protein coding RNA 2701

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular metal ion homeostasis NAS
Non-traceable Author Statement
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to metal ion NAS
Non-traceable Author Statement
more info
PubMed 
spermatogenesis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
tesmin
Names
CXC domain containing 2
metallothionein-like 5, testis-specific (tesmin)
testis-specific metallothionein-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039656.1NP_001034745.1  tesmin isoform b

    See identical proteins and their annotated locations for NP_001034745.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the C-terminus compared to isoform a.
    Source sequence(s)
    AP003096, BC027593, BM790577
    Consensus CDS
    CCDS44661.1
    UniProtKB/Swiss-Prot
    Q9Y4I5
    Related
    ENSP00000440968.1, ENST00000544963.1
  2. NM_004923.3NP_004914.2  tesmin isoform a

    See identical proteins and their annotated locations for NP_004914.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    BC064579, BM790577
    Consensus CDS
    CCDS8184.1
    UniProtKB/Swiss-Prot
    Q9Y4I5
    Related
    ENSP00000255087.5, ENST00000255087.10
    Conserved Domains (1) summary
    pfam03638
    Location:367404
    TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    68706674..68751564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018588.1XP_016874077.1  tesmin isoform X2

  2. XM_011545402.1XP_011543704.1  tesmin isoform X1

    See identical proteins and their annotated locations for XP_011543704.1

    Conserved Domains (1) summary
    pfam03638
    Location:367404
    TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain
  3. XM_011545403.2XP_011543705.1  tesmin isoform X1

    See identical proteins and their annotated locations for XP_011543705.1

    Conserved Domains (1) summary
    pfam03638
    Location:367404
    TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

RNA

  1. XR_950115.1 RNA Sequence

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