Map7 microtubule-associated protein 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Map7provided by MGI
Official Full Name: microtubule-associated protein 7provided by MGI
Primary source: MGI:MGI:1328328
See related: Ensembl:ENSMUSG00000019996 AllianceGenome:MGI:1328328
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ste; mshi; mste; MAP-7; Mtap7; E-MAP-115
Summary: Enables signaling receptor binding activity. Involved in protein localization to plasma membrane and response to osmotic stress. Acts upstream of or within several processes, including gamete generation; male gonad development; and response to retinoic acid. Located in plasma membrane. Is expressed in several structures, including alimentary system; endocrine gland; ganglia; genitourinary system; and skin. Orthologous to human MAP7 (microtubule associated protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 10.3), cortex adult (RPKM 7.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A3; 10 9.75 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (20024666..20157336)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (20148920..20281590)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAP7 binds to the acetylated and stable region of individual microtubules and rescues microtubule polymerization in developing sensory neurons.
Title: MAP7 Prevents Axonal Branch Retraction by Creating a Stable Microtubule Boundary to Rescue Polymerization.
MAP7D2 interacts with all three kinesin-1 family members and accumulates in the proximal axon through its N-terminal microtubule-binding domain. Depletion of MAP7D2 results in reduced axonal cargo entry.
Title: MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon.
MAP7 does not alter the force exerted by a single kinesin-1 motor, but instead increases its binding rate to the microtubule
Title: MAP7 regulates organelle transport by recruiting kinesin-1 to microtubules.
identification of the microtubule-associated protein ensconsin (Ens)/microtubule-associated protein 7 (MAP7) and kinesin heavy chain (Khc)/Kif5b as essential, evolutionarily conserved regulators of myonuclear positioning in Drosophila and cultured mammalian myotubes
Title: MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function.
Complementation testing showed that one of these, Mtap7, is disrupted in mshi mice.
Title: The male sterility and histoincompatibility (mshi) mutation in mice is a natural variant of microtubule-associated protein 7 (Mtap7).
MAP7 is the TRPV4 C-terminal binding protein; alignment of a.a.798-809 of TRPV4 was important in this interaction; TRPV4 and MAP7 colocalized in lung and kidney; coexpression resulted in redistribution of TRPV4 and enhanced membrane expression of TRPV4
Title: Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4).

Submit: New GeneRIF Correction

Phenotypes

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Associated conditions

Description	Tests
male sterility and histoincompatibility GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Gene trapped (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125144 (e-PCR)
- UniSTS:161966

BB015768 (e-PCR)
- UniSTS:185818

Homology

Homologs of the Map7 gene: The Map7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 348 organisms have orthologs with human gene Map7
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Leydig cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Sertoli cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glycosphingolipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule bundle formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within nucleus organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to osmotic stress	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within response to retinoic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ensconsin

Names: epithelial microtubule-associated protein of 115 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198635.1 → NP_001185564.1 ensconsin isoform 2

See identical proteins and their annotated locations for NP_001185564.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) has an additional segment, as compared to isoform 1.

Source sequence(s)

BC052637, BY277244

Consensus CDS

CCDS56694.1

UniProtKB/Swiss-Prot

O88735

UniProtKB/TrEMBL

D3YWN7

Related

ENSMUSP00000111963.4, ENSMUST00000116259.5

Conserved Domains (1) summary

pfam05672
Location:458 → 610

MAP7; MAP7 (E-MAP-115) family
NM_001358787.1 → NP_001345716.1 ensconsin isoform 3

Status: VALIDATED

Source sequence(s)

AB098611, AK014575, BC052637, BY264190

Conserved Domains (3) summary

pfam03999
Location:111 → 337

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

pfam05672
Location:472 → 625

MAP7; MAP7 (E-MAP-115) family

pfam09756
Location:101 → 174

DDRGK; DDRGK domain
NM_008635.2 → NP_032661.2 ensconsin isoform 1

See identical proteins and their annotated locations for NP_032661.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the dominant transcript and encodes isoform 1.

Source sequence(s)

AB098611, AK014575, BC052637, BY277244, CJ074623

Consensus CDS

CCDS87968.1

UniProtKB/Swiss-Prot

O88735

UniProtKB/TrEMBL

E9QMU3

Related

ENSMUSP00000020173.10, ENSMUST00000020173.16

Conserved Domains (1) summary

pfam05672
Location:450 → 602

MAP7; MAP7 (E-MAP-115) family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

20024666..20157336

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155666.1 → XP_036011559.1 ensconsin isoform X8

Conserved Domains (1) summary

pfam05672
Location:312 → 464

MAP7; MAP7 (E-MAP-115) family
XM_006512577.4 → XP_006512640.1 ensconsin isoform X1

See identical proteins and their annotated locations for XP_006512640.1

Conserved Domains (2) summary

pfam05672
Location:480 → 632

MAP7; MAP7 (E-MAP-115) family

pfam15927
Location:111 → 180

Casc1_N; Cancer susceptibility candidate 1 N-terminus
XM_036155665.1 → XP_036011558.1 ensconsin isoform X4

Conserved Domains (2) summary

pfam05672
Location:442 → 594

MAP7; MAP7 (E-MAP-115) family

pfam06098
Location:111 → 168

Radial_spoke_3; Radial spoke protein 3
XM_006512582.4 → XP_006512645.1 ensconsin isoform X6

Conserved Domains (2) summary

pfam05672
Location:434 → 586

MAP7; MAP7 (E-MAP-115) family

pfam15927
Location:111 → 180

Casc1_N; Cancer susceptibility candidate 1 N-terminus
XM_036155667.1 → XP_036011560.1 ensconsin isoform X9

Conserved Domains (1) summary

pfam05672
Location:274 → 426

MAP7; MAP7 (E-MAP-115) family
XM_006512584.5 → XP_006512647.1 ensconsin isoform X8

See identical proteins and their annotated locations for XP_006512647.1

Conserved Domains (1) summary

pfam05672
Location:312 → 464

MAP7; MAP7 (E-MAP-115) family
XM_006512585.5 → XP_006512648.1 ensconsin isoform X8

See identical proteins and their annotated locations for XP_006512648.1

Conserved Domains (1) summary

pfam05672
Location:312 → 464

MAP7; MAP7 (E-MAP-115) family
XM_006512580.3 → XP_006512643.1 ensconsin isoform X3

Conserved Domains (2) summary

pfam05672
Location:443 → 595

MAP7; MAP7 (E-MAP-115) family

pfam15927
Location:74 → 145

Casc1_N; Cancer susceptibility candidate 1 N-terminus
XM_006512581.3 → XP_006512644.1 ensconsin isoform X5

Conserved Domains (2) summary

pfam05672
Location:435 → 587

MAP7; MAP7 (E-MAP-115) family

pfam15927
Location:74 → 143

Casc1_N; Cancer susceptibility candidate 1 N-terminus
XM_006512583.4 → XP_006512646.1 ensconsin isoform X7

Conserved Domains (2) summary

pfam05672
Location:421 → 573

MAP7; MAP7 (E-MAP-115) family

pfam15927
Location:98 → 167

Casc1_N; Cancer susceptibility candidate 1 N-terminus
XM_006512579.4 → XP_006512642.1 ensconsin isoform X2

Conserved Domains (2) summary

pfam05672
Location:467 → 619

MAP7; MAP7 (E-MAP-115) family

pfam09756
Location:88 → 161

DDRGK; DDRGK domain
XM_036155668.1 → XP_036011561.1 ensconsin isoform X10

Conserved Domains (1) summary

pfam05672
Location:193 → 345

MAP7; MAP7 (E-MAP-115) family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001198636.1: Suppressed sequence

Description

NM_001198636.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.