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Map7 microtubule-associated protein 7 [ Mus musculus (house mouse) ]

Gene ID: 17761, updated on 8-Feb-2024

Summary

Official Symbol
Map7provided by MGI
Official Full Name
microtubule-associated protein 7provided by MGI
Primary source
MGI:MGI:1328328
See related
Ensembl:ENSMUSG00000019996 AllianceGenome:MGI:1328328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ste; mshi; mste; MAP-7; Mtap7; E-MAP-115
Summary
Enables signaling receptor binding activity. Involved in protein localization to plasma membrane and response to osmotic stress. Acts upstream of or within several processes, including gamete generation; male gonad development; and response to retinoic acid. Located in plasma membrane. Is expressed in several structures, including alimentary system; endocrine gland; ganglia; genitourinary system; and skin. Orthologous to human MAP7 (microtubule associated protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 10.3), cortex adult (RPKM 7.2) and 27 other tissues See more
Orthologs
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Genomic context

See Map7 in Genome Data Viewer
Location:
10 A3; 10 9.75 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (20024666..20157336)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (20148920..20281590)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25941 Neighboring gene STARR-seq mESC enhancer starr_25942 Neighboring gene peroxisomal biogenesis factor 7 Neighboring gene STARR-seq mESC enhancer starr_25943 Neighboring gene STARR-positive B cell enhancer ABC_E10597 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:19659120-19659310 Neighboring gene mitogen-activated protein kinase kinase kinase 5 Neighboring gene STARR-seq mESC enhancer starr_25945 Neighboring gene STARR-positive B cell enhancer mm9_chr10:19711687-19711987 Neighboring gene STARR-positive B cell enhancer ABC_E8326 Neighboring gene STARR-positive B cell enhancer ABC_E11432 Neighboring gene STARR-seq mESC enhancer starr_25946 Neighboring gene STARR-seq mESC enhancer starr_25947 Neighboring gene STARR-seq mESC enhancer starr_25949 Neighboring gene STARR-seq mESC enhancer starr_25952 Neighboring gene RIKEN cDNA 4930405J17 gene Neighboring gene predicted gene, 51795 Neighboring gene STARR-seq mESC enhancer starr_25958 Neighboring gene ribosomal protein L32-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:19977636-19977875 Neighboring gene predicted gene, 48249 Neighboring gene predicted gene, 30285 Neighboring gene microRNA 6413

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
male sterility and histoincompatibility
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Leydig cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Sertoli cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glycosphingolipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nucleus organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to osmotic stress IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to osmotic stress IPI
Inferred from Physical Interaction
more info
PubMed 
acts_upstream_of_or_within response to retinoic acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ensconsin
Names
epithelial microtubule-associated protein of 115 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198635.1NP_001185564.1  ensconsin isoform 2

    See identical proteins and their annotated locations for NP_001185564.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) has an additional segment, as compared to isoform 1.
    Source sequence(s)
    BC052637, BY277244
    Consensus CDS
    CCDS56694.1
    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    UniProtKB/TrEMBL
    D3YWN7
    Related
    ENSMUSP00000111963.4, ENSMUST00000116259.5
    Conserved Domains (1) summary
    pfam05672
    Location:458610
    MAP7; MAP7 (E-MAP-115) family
  2. NM_001358787.1NP_001345716.1  ensconsin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AB098611, AK014575, BC052637, BY264190
    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (3) summary
    pfam03999
    Location:111337
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam05672
    Location:472625
    MAP7; MAP7 (E-MAP-115) family
    pfam09756
    Location:101174
    DDRGK; DDRGK domain
  3. NM_008635.2NP_032661.2  ensconsin isoform 1

    See identical proteins and their annotated locations for NP_032661.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the dominant transcript and encodes isoform 1.
    Source sequence(s)
    AB098611, AK014575, BC052637, BY277244, CJ074623
    Consensus CDS
    CCDS87968.1
    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    UniProtKB/TrEMBL
    E9QMU3
    Related
    ENSMUSP00000020173.10, ENSMUST00000020173.16
    Conserved Domains (1) summary
    pfam05672
    Location:450602
    MAP7; MAP7 (E-MAP-115) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    20024666..20157336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155666.1XP_036011559.1  ensconsin isoform X8

    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (1) summary
    pfam05672
    Location:312464
    MAP7; MAP7 (E-MAP-115) family
  2. XM_006512577.4XP_006512640.1  ensconsin isoform X1

    See identical proteins and their annotated locations for XP_006512640.1

    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (2) summary
    pfam05672
    Location:480632
    MAP7; MAP7 (E-MAP-115) family
    pfam15927
    Location:111180
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  3. XM_036155665.1XP_036011558.1  ensconsin isoform X4

    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (2) summary
    pfam05672
    Location:442594
    MAP7; MAP7 (E-MAP-115) family
    pfam06098
    Location:111168
    Radial_spoke_3; Radial spoke protein 3
  4. XM_006512582.4XP_006512645.1  ensconsin isoform X6

    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (2) summary
    pfam05672
    Location:434586
    MAP7; MAP7 (E-MAP-115) family
    pfam15927
    Location:111180
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  5. XM_036155667.1XP_036011560.1  ensconsin isoform X9

    Conserved Domains (1) summary
    pfam05672
    Location:274426
    MAP7; MAP7 (E-MAP-115) family
  6. XM_006512584.5XP_006512647.1  ensconsin isoform X8

    See identical proteins and their annotated locations for XP_006512647.1

    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (1) summary
    pfam05672
    Location:312464
    MAP7; MAP7 (E-MAP-115) family
  7. XM_006512585.5XP_006512648.1  ensconsin isoform X8

    See identical proteins and their annotated locations for XP_006512648.1

    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (1) summary
    pfam05672
    Location:312464
    MAP7; MAP7 (E-MAP-115) family
  8. XM_006512580.3XP_006512643.1  ensconsin isoform X3

    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (2) summary
    pfam05672
    Location:443595
    MAP7; MAP7 (E-MAP-115) family
    pfam15927
    Location:74145
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  9. XM_006512581.3XP_006512644.1  ensconsin isoform X5

    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (2) summary
    pfam05672
    Location:435587
    MAP7; MAP7 (E-MAP-115) family
    pfam15927
    Location:74143
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  10. XM_006512583.4XP_006512646.1  ensconsin isoform X7

    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (2) summary
    pfam05672
    Location:421573
    MAP7; MAP7 (E-MAP-115) family
    pfam15927
    Location:98167
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
  11. XM_006512579.4XP_006512642.1  ensconsin isoform X2

    UniProtKB/Swiss-Prot
    O88735, Q3V0B9, Q7TQL9, Q80V60
    Conserved Domains (2) summary
    pfam05672
    Location:467619
    MAP7; MAP7 (E-MAP-115) family
    pfam09756
    Location:88161
    DDRGK; DDRGK domain
  12. XM_036155668.1XP_036011561.1  ensconsin isoform X10

    Conserved Domains (1) summary
    pfam05672
    Location:193345
    MAP7; MAP7 (E-MAP-115) family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001198636.1: Suppressed sequence

    Description
    NM_001198636.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.