Format

Send to:

Choose Destination

MAP7 microtubule associated protein 7 [ Homo sapiens (human) ]

Gene ID: 9053, updated on 11-Sep-2019

Summary

Official Symbol
MAP7provided by HGNC
Official Full Name
microtubule associated protein 7provided by HGNC
Primary source
HGNC:HGNC:6869
See related
Ensembl:ENSG00000135525 MIM:604108
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EMAP115; E-MAP-115
Summary
The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Expression
Broad expression in kidney (RPKM 10.5), brain (RPKM 10.5) and 21 other tissues See more
Orthologs

Genomic context

See MAP7 in Genome Data Viewer
Location:
6q23.3
Exon count:
21
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (136342281..136550819, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (136663419..136871957, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene mitochondrial fission regulator 2 Neighboring gene BCL2 associated transcription factor 1 Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 8 Neighboring gene phosphopantothenate--cysteine ligase pseudogene Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 pseudogene 1 Neighboring gene RN7SK pseudogene 299 Neighboring gene mitogen-activated protein kinase kinase kinase 5 Neighboring gene MAP3K5 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 219 Neighboring gene uncharacterized LOC101928429 Neighboring gene Sharpr-MPRA regulatory region 14394

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
establishment or maintenance of cell polarity TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
response to osmotic stress ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule associated complex TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ensconsin
Names
MAP-7
dJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP-115))
epithelial microtubule-associated protein of 115 kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198608.1NP_001185537.1  ensconsin isoform 1

    See identical proteins and their annotated locations for NP_001185537.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI344295, AJ420541, AK294461, AK296556, BC025777, DA341792, DC325462, DC332469
    Consensus CDS
    CCDS56455.1
    UniProtKB/Swiss-Prot
    Q14244
    Conserved Domains (2) summary
    pfam05672
    Location:485641
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:106178
    Tho2; Transcription factor/nuclear export subunit protein 2
  2. NM_001198609.1NP_001185538.1  ensconsin isoform 2

    See identical proteins and their annotated locations for NP_001185538.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) has an additional segment, as compared to isoform 1.
    Source sequence(s)
    AI344295, AJ420541, AK294461, AK295749, DA341792, DC325462, DC332469
    Consensus CDS
    CCDS75527.1
    UniProtKB/Swiss-Prot
    Q14244
    UniProtKB/TrEMBL
    A0A087WZ40, B7Z3E1
    Related
    ENSP00000482335.1, ENST00000617204.4
    Conserved Domains (2) summary
    pfam05672
    Location:493649
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:106178
    Tho2; Transcription factor/nuclear export subunit protein 2
  3. NM_001198611.1NP_001185540.1  ensconsin isoform 4

    See identical proteins and their annotated locations for NP_001185540.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (4) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AI344295, AJ420541, AK294461, DA341792, DC325462, DC332469
    Consensus CDS
    CCDS56454.1
    UniProtKB/Swiss-Prot
    Q14244
    Related
    ENSP00000400790.2, ENST00000438100.6
    Conserved Domains (2) summary
    pfam05672
    Location:448604
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:106178
    Tho2; Transcription factor/nuclear export subunit protein 2
  4. NM_001198614.1NP_001185543.1  ensconsin isoform 1

    See identical proteins and their annotated locations for NP_001185543.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR, as comapred to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AI344295, AJ420541, AK294461, AK311270, AK316529, BC025777, DA341792
    Consensus CDS
    CCDS56455.1
    UniProtKB/Swiss-Prot
    Q14244
    UniProtKB/TrEMBL
    B7ZB64
    Related
    ENSP00000414712.1, ENST00000454590.5
    Conserved Domains (2) summary
    pfam05672
    Location:485641
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:106178
    Tho2; Transcription factor/nuclear export subunit protein 2
  5. NM_001198615.1NP_001185544.1  ensconsin isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has an alternate 5' exon, as compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AI344295, AJ420541, AK294461, AK299355, BC025777, DA341792
    Consensus CDS
    CCDS56453.1
    UniProtKB/Swiss-Prot
    Q14244
    Related
    ENSP00000445737.1, ENST00000544465.5
    Conserved Domains (2) summary
    pfam05672
    Location:448604
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:69141
    Tho2; Transcription factor/nuclear export subunit protein 2
  6. NM_001198616.1NP_001185545.1  ensconsin isoform 6

    See identical proteins and their annotated locations for NP_001185545.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate 5' exon and lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (6) has a shorter and distinct N-terminus and lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AI344295, AJ242502, AJ420541, AL042021, DA329576, DA341792
    Consensus CDS
    CCDS75529.1
    UniProtKB/Swiss-Prot
    Q14244
    Related
    ENSP00000482356.1, ENST00000618822.4
    Conserved Domains (2) summary
    pfam05672
    Location:426582
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:84156
    Tho2; Transcription factor/nuclear export subunit protein 2
  7. NM_001198617.1NP_001185546.1  ensconsin isoform 7

    See identical proteins and their annotated locations for NP_001185546.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has an alternate 5' exon and lacks two consecutive in-frame exons in the CDS, as compared to variant 1. The resulting isoform (7) has a shorter and distinct N-terminus and lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AI344295, AJ242501, AJ420541, AL042021, DA329576, DA341792
    Consensus CDS
    CCDS75528.1
    UniProtKB/Swiss-Prot
    Q14244
    Related
    ENSP00000483511.1, ENST00000616617.4
    Conserved Domains (1) summary
    pfam05672
    Location:369525
    MAP7; MAP7 (E-MAP-115) family
  8. NM_001198618.1NP_001185547.1  ensconsin isoform 8

    See identical proteins and their annotated locations for NP_001185547.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has an alternate 5' exon, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (8) is shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AI344295, AJ420541, AK294461, AK296483, BC025777, DA341792
    Consensus CDS
    CCDS56452.1
    UniProtKB/Swiss-Prot
    Q14244
    UniProtKB/TrEMBL
    B7Z3Y3
    Related
    ENSP00000414879.2, ENST00000432797.6
    Conserved Domains (1) summary
    pfam05672
    Location:317473
    MAP7; MAP7 (E-MAP-115) family
  9. NM_001198619.1NP_001185548.1  ensconsin isoform 8

    See identical proteins and their annotated locations for NP_001185548.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has an alternate 5' exon, resulting in a downstream AUG start codon, as compared to variant 1. Variants 9 and 10 encode the same isoform (8), which is shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AI344295, AJ420541, AK316062, DA341792
    Consensus CDS
    CCDS56452.1
    UniProtKB/Swiss-Prot
    Q14244
    Related
    ENSP00000482998.1, ENST00000611373.1
    Conserved Domains (1) summary
    pfam05672
    Location:317473
    MAP7; MAP7 (E-MAP-115) family
  10. NM_003980.4NP_003971.1  ensconsin isoform 3

    See identical proteins and their annotated locations for NP_003971.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' exon, as compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AI344295, AJ420541, AL042021, DA329576, DA341792, X73882
    Consensus CDS
    CCDS5178.1
    UniProtKB/Swiss-Prot
    Q14244
    Related
    ENSP00000346581.2, ENST00000354570.7
    Conserved Domains (2) summary
    pfam05672
    Location:463619
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:84156
    Tho2; Transcription factor/nuclear export subunit protein 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    136342281..136550819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536245.2XP_011534547.1  ensconsin isoform X7

    Conserved Domains (2) summary
    pfam05672
    Location:434590
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:84156
    Tho2; Transcription factor/nuclear export subunit protein 2
  2. XM_006715601.4XP_006715664.1  ensconsin isoform X3

    Conserved Domains (2) summary
    pfam05672
    Location:471627
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:84156
    Tho2; Transcription factor/nuclear export subunit protein 2
  3. XM_006715599.3XP_006715662.1  ensconsin isoform X1

    See identical proteins and their annotated locations for XP_006715662.1

    UniProtKB/TrEMBL
    A0A087WZ40
    Conserved Domains (2) summary
    pfam05672
    Location:493649
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:106178
    Tho2; Transcription factor/nuclear export subunit protein 2
  4. XM_006715600.3XP_006715663.1  ensconsin isoform X2

    See identical proteins and their annotated locations for XP_006715663.1

    UniProtKB/Swiss-Prot
    Q14244
    Conserved Domains (2) summary
    pfam05672
    Location:485641
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:106178
    Tho2; Transcription factor/nuclear export subunit protein 2
  5. XM_006715598.3XP_006715661.1  ensconsin isoform X1

    See identical proteins and their annotated locations for XP_006715661.1

    UniProtKB/TrEMBL
    A0A087WZ40
    Conserved Domains (2) summary
    pfam05672
    Location:493649
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:106178
    Tho2; Transcription factor/nuclear export subunit protein 2
  6. XM_011536246.2XP_011534548.1  ensconsin isoform X8

    Conserved Domains (2) summary
    pfam05672
    Location:419575
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:69141
    Tho2; Transcription factor/nuclear export subunit protein 2
  7. XM_011536243.2XP_011534545.1  ensconsin isoform X4

    Conserved Domains (2) summary
    pfam05672
    Location:456612
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:69141
    Tho2; Transcription factor/nuclear export subunit protein 2
  8. XM_011536244.3XP_011534546.1  ensconsin isoform X5

    Conserved Domains (2) summary
    pfam05672
    Location:456612
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:106178
    Tho2; Transcription factor/nuclear export subunit protein 2
  9. XM_017011471.2XP_016866960.1  ensconsin isoform X6

    UniProtKB/Swiss-Prot
    Q14244
    Conserved Domains (2) summary
    pfam05672
    Location:448604
    MAP7; MAP7 (E-MAP-115) family
    pfam11262
    Location:106178
    Tho2; Transcription factor/nuclear export subunit protein 2
Support Center