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nhr-31 Nuclear hormone receptor family member nhr-31 [ Caenorhabditis elegans ]

Gene ID: 177601, updated on 18-Sep-2024

Summary

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Official Symbol
nhr-31
Official Full Name
Nuclear hormone receptor family member nhr-31
Primary source
WormBase:WBGene00003625
Locus tag
CELE_C26B2.3
See related
AllianceGenome:WB:WBGene00003625
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Involved in embryo development; post-embryonic animal morphogenesis; and response to osmotic stress. Predicted to be located in nucleus. Is expressed in excretory cell. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (8022655..8029513, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Elongator complex protein 4 Neighboring gene Dynactin subunit 4 Neighboring gene Membrane-associated kinase regulator Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans HNF4alpha Homolog, NHR-31, mediates excretory tube growth and function through coordinate regulation of the vacuolar ATPase. Hahn-Windgassen A, et al. PLoS Genet, 2009 Jul. PMID 19668342, Free PMC Article
  2. Prorenin Receptor Homologue VHA-20 is Critical for Intestinal pH Regulation, Ion and Water Management and Larval Development in C. elegans. Zima V, et al. Folia Biol (Praha), 2015. PMID 26667573
  3. Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival. Murphy JT, et al. PLoS Biol, 2019 May. PMID 31086360, Free PMC Article
  4. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  5. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HNF4-type plays roles in the development and function of a renal system.
    Title: The Caenorhabditis elegans HNF4alpha Homolog, NHR-31, mediates excretory tube growth and function through coordinate regulation of the vacuolar ATPase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-embryonic animal morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear hormone receptor family member nhr-31
NP_001379703.1
  • Confirmed by transcript evidence
NP_741456.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8022655..8029513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171391.7 → NP_741456.1  Nuclear hormone receptor family member nhr-31 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741456.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18192, Q5TYL7, Q8MQB8
    UniProtKB/TrEMBL
    Q9GTI0
    Conserved Domains (2) summary
    cd06157
    Location:259 → 423
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    cd06960
    Location:82 → 157
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  2. NM_001392341.1 → NP_001379703.1  Nuclear hormone receptor family member nhr-31 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTH9
    Conserved Domains (2) summary
    cd06157
    Location:220 → 384
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    cd06960
    Location:43 → 118
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

RNA

  1. NR_131580.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18192.2

Gene LinkOut

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