U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mt2 metallothionein 2 [ Mus musculus (house mouse) ]

Gene ID: 17750, updated on 27-Nov-2024

Summary

Official Symbol
Mt2provided by MGI
Official Full Name
metallothionein 2provided by MGI
Primary source
MGI:MGI:97172
See related
Ensembl:ENSMUSG00000031762 AllianceGenome:MGI:97172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mt-2; MT-II
Summary
Predicted to enable cadmium ion binding activity and zinc ion binding activity. Acts upstream of or within several processes, including detoxification of copper ion; intracellular zinc ion homeostasis; and nitric oxide mediated signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including gut; liver lobe; lung; sensory organ; and telencephalon. Human ortholog(s) of this gene implicated in carotid stenosis and type 2 diabetes mellitus. Orthologous to several human genes including MT2A (metallothionein 2A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver E14.5 (RPKM 757.6), liver E14 (RPKM 674.1) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Mt2 in Genome Data Viewer
Location:
8 C5; 8 46.32 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94899246..94900195)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94172618..94173567)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene metallothionein 3 Neighboring gene predicted gene, 39227 Neighboring gene metallothionein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:96707225-96707334 Neighboring gene uncharacterized LOC118567560

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cadmium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to cadmium ion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to copper ion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to zinc ion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in detoxification of copper ion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within detoxification of copper ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within intracellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of growth ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within nitric oxide mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
metallothionein-2
Names
metallothionein-II

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008630.2NP_032656.1  metallothionein-2

    See identical proteins and their annotated locations for NP_032656.1

    Status: VALIDATED

    Source sequence(s)
    AK002567, AV014447, BY159747
    Consensus CDS
    CCDS40437.1
    UniProtKB/Swiss-Prot
    P02798
    UniProtKB/TrEMBL
    Q6VEU6
    Related
    ENSMUSP00000034214.7, ENSMUST00000034214.8
    Conserved Domains (1) summary
    pfam00131
    Location:461
    Metallothio; Metallothionein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    94899246..94900195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)