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vha-19 V-type proton ATPase subunit S1 [ Caenorhabditis elegans ]

Gene ID: 177103, updated on 23-Nov-2023

Summary

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Gene symbol
vha-19
Gene description
V-type proton ATPase subunit S1
Primary source
WormBase:WBGene00021952
Locus tag
CELE_Y55H10A.1
See related
AllianceGenome:WB:WBGene00021952
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in cellular water homeostasis; positive regulation of oocyte development; and positive regulation of protein targeting to membrane. Located in membrane raft. Is expressed in excretory cell; hypodermis; intestine; pharynx; and vulva. Human ortholog(s) of this gene implicated in immunodeficiency 47. Orthologous to several human genes including ATP6AP1 (ATPase H+ transporting accessory protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (3369197..3373485)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene OTU domain-containing protein Neighboring gene SRR1 domain-containing protein;Yippee domain-containing protein Neighboring gene Protein yippee-like B0546.4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. VHA-19 is essential in Caenorhabditis elegans oocytes for embryogenesis and is involved in trafficking in oocytes. Knight AJ, et al. PLoS One, 2012. PMID 22768351, Free PMC Article
  2. Silencing of essential genes by RNA interference in Haemonchus contortus. Zawadzki JL, et al. Parasitology, 2012 Apr. PMID 22348596
  3. An analysis of the Caenorhabditis elegans lipid raft proteome using geLC-MS/MS. Rao W, et al. J Proteomics, 2011 Feb 1. PMID 21070894
  4. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
  5. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans. Updike DL, et al. Genetics, 2009 Dec. PMID 19805813, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular water homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of oocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft HDA PubMed 
part_of proton-transporting V-type ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
V-type proton ATPase subunit S1
NP_500332.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3369197..3373485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067931.5 → NP_500332.1  V-type proton ATPase subunit S1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500332.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9TYW1
    Conserved Domains (1) summary
    pfam05827
    Location:16 → 430
    ATP-synt_S1; Vacuolar ATP synthase subunit S1 (ATP6S1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TYW1.1

Gene LinkOut

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