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Msh2 mutS homolog 2 [ Mus musculus (house mouse) ]

Gene ID: 17685, updated on 12-Aug-2018

Summary

Official Symbol
Msh2provided by MGI
Official Full Name
mutS homolog 2provided by MGI
Primary source
MGI:MGI:101816
See related
Ensembl:ENSMUSG00000024151 Vega:OTTMUSG00000038134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI788990
Expression
Broad expression in CNS E11.5 (RPKM 24.0), CNS E14 (RPKM 14.5) and 24 other tissues See more
Orthologs

Genomic context

See Msh2 in Genome Data Viewer
Location:
17 E4; 17 57.87 cM
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (87672557..87723713)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (88071897..88123053)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 46609 Neighboring gene epithelial cell adhesion molecule Neighboring gene potassium channel, subfamily K, member 12 Neighboring gene predicted gene, 41649

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
CONTRIBUTES_TO ADP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ADP binding ISO
Inferred from Sequence Orthology
more info
 
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ATP binding ISO
Inferred from Sequence Orthology
more info
 
ATPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to ATPase activity ISO
Inferred from Sequence Orthology
more info
 
DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-dependent ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CONTRIBUTES_TO MutLalpha complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to MutLalpha complex binding ISO
Inferred from Sequence Orthology
more info
 
Y-form DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centromeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
damaged DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to dinucleotide insertion or deletion binding ISO
Inferred from Sequence Orthology
more info
 
CONTRIBUTES_TO dinucleotide repeat insertion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to dinucleotide repeat insertion binding ISO
Inferred from Sequence Orthology
more info
 
double-strand/single-strand DNA junction binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
four-way junction DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to four-way junction DNA binding ISO
Inferred from Sequence Orthology
more info
 
CONTRIBUTES_TO guanine/thymine mispair binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to guanine/thymine mispair binding IDA
Inferred from Direct Assay
more info
PubMed 
guanine/thymine mispair binding ISO
Inferred from Sequence Orthology
more info
PubMed 
contributes_to guanine/thymine mispair binding ISO
Inferred from Sequence Orthology
more info
 
heteroduplex DNA loop binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CONTRIBUTES_TO magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
mismatched DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to mismatched DNA binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
CONTRIBUTES_TO oxidized purine DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to oxidized purine DNA binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
CONTRIBUTES_TO single guanine insertion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to single guanine insertion binding ISO
Inferred from Sequence Orthology
more info
 
CONTRIBUTES_TO single thymine insertion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to single thymine insertion binding ISO
Inferred from Sequence Orthology
more info
 
CONTRIBUTES_TO single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
B cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA repair ISO
Inferred from Sequence Orthology
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intra-S DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intra-S DNA damage checkpoint IGI
Inferred from Genetic Interaction
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
Inferred from Genetic Interaction
more info
PubMed 
isotype switching IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of DNA repeat elements IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
maintenance of DNA repeat elements ISO
Inferred from Sequence Orthology
more info
 
male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic gene conversion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
meiotic mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair IDA
Inferred from Direct Assay
more info
PubMed 
mismatch repair IGI
Inferred from Genetic Interaction
more info
PubMed 
mismatch repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
mismatch repair ISO
Inferred from Sequence Orthology
more info
PubMed 
mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of DNA recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA recombination ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidative phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of helicase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of isotype switching to IgA isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of isotype switching to IgG isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postreplication repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
postreplication repair ISO
Inferred from Sequence Orthology
more info
 
pyrimidine dimer repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
replication fork arrest IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to UV-B IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to UV-B IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to X-ray IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to X-ray IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic hypermutation of immunoglobulin genes IGI
Inferred from Genetic Interaction
more info
PubMed 
somatic hypermutation of immunoglobulin genes IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT somatic hypermutation of immunoglobulin genes IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic recombination of immunoglobulin gene segments IGI
Inferred from Genetic Interaction
more info
PubMed 
somatic recombination of immunoglobulin gene segments IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic recombination of immunoglobulin genes involved in immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
MutSalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MutSalpha complex IDA
Inferred from Direct Assay
more info
PubMed 
MutSalpha complex ISO
Inferred from Sequence Orthology
more info
 
MutSbeta complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MutSbeta complex ISO
Inferred from Sequence Orthology
more info
 
mismatch repair complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair complex IEA
Inferred from Electronic Annotation
more info
 
nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA mismatch repair protein Msh2
Names
mutS protein homolog 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008628.3NP_032654.1  DNA mismatch repair protein Msh2

    See identical proteins and their annotated locations for NP_032654.1

    Status: VALIDATED

    Source sequence(s)
    AC163652
    Consensus CDS
    CCDS29019.1
    UniProtKB/Swiss-Prot
    P43247
    UniProtKB/TrEMBL
    Q3TZI5
    Related
    ENSMUSP00000024967.7, OTTMUSP00000055147, ENSMUST00000024967.13
    Conserved Domains (6) summary
    cd03285
    Location:633852
    ABC_MSH2_euk; ATP-binding cassette domain of eukaryotic MutS2 homolog
    COG0249
    Location:26853
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:18132
    MutS_I; MutS domain I
    pfam05188
    Location:152284
    MutS_II; MutS domain II
    pfam05190
    Location:473569
    MutS_IV; MutS family domain IV
    pfam05192
    Location:305423
    MutS_III; MutS domain III

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    87672557..87723713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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