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MSH2 mutS homolog 2 [ Homo sapiens (human) ]

Gene ID: 4436, updated on 9-Jun-2025
Official Symbol
MSH2provided by HGNC
Official Full Name
mutS homolog 2provided by HGNC
Primary source
HGNC:HGNC:7325
See related
Ensembl:ENSG00000095002 MIM:609309; AllianceGenome:HGNC:7325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FCC1; COCA1; HNPCC; LCFS2; MSH-2; hMSH2; HNPCC1; LYNCH1; MMRCS2
Summary
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Expression
Ubiquitous expression in lymph node (RPKM 3.7), testis (RPKM 3.4) and 25 other tissues See more
Orthologs
mouse all
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Try the new Gene table
Try the new Transcript table
See MSH2 in Genome Data Viewer
Location:
2p21-p16.3
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (47403067..47709830)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (47408101..47714827)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (47630206..47936969)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:47596083-47596759 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:47596760-47597435 Neighboring gene RN7SK pseudogene 119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15732 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:47630036-47630746 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:47630747-47631455 Neighboring gene epithelial cell adhesion molecule Neighboring gene microRNA 559 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:47653397-47653896 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:47699841-47700005 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15734 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:47761774-47762289 Neighboring gene potassium two pore domain channel subfamily K member 12 Neighboring gene MSH2 overlapping transcript 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:47796495-47797364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:47798518-47799048 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:47799049-47799577 Neighboring gene Sharpr-MPRA regulatory region 1309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15736 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:47891127-47891628 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:47891629-47892128 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:47918101-47918767 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:47921671-47922214 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11466 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:47923304-47923848 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:47923849-47924392 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:47925482-47926026 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:47928206-47928749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15737 Neighboring gene ribosomal protein L18a pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15738 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:47948619-47949424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15739 Neighboring gene NME2 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:47975285-47975438 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15740 Neighboring gene uncharacterized LOC105374589 Neighboring gene RBIS pseudogene 5

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Cerebral primitive neuroectodermal tumor in an adult with a heterozygous MSH2 mutation. Jeans AF, et al. Nat Rev Clin Oncol, 2009 May. PMID 19390556
  2. Impact of 226C>T MSH2 gene mutation on cancer phenotypes in two HNPCC-associated highly-consanguineous families from Kuwait: emphasis on premarital genetic testing. Marafie MJ, et al. Fam Cancer, 2009. PMID 19669601
  3. Differential MSH2 promoter methylation in blood cells of Neurofibromatosis type 1 (NF1) patients. Titze S, et al. Eur J Hum Genet, 2010 Jan. PMID 19639020, Free PMC Article
  4. RNA Analysis Identifies Pathogenic Duplications in MSH2 in Patients With Lynch Syndrome. Conner BR, et al. Gastroenterology, 2019 May. PMID 30710526, Free PMC Article
  5. Frequency and variability of genomic rearrangements on MSH2 in Spanish Lynch Syndrome families. Romero A, et al. PLoS One, 2013. PMID 24039744, Free PMC Article

See all (929) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Assessing the role of MSH2 and MSH6 gene expression deficiency in prostate cancer progression, a cross-sectional study.
    Title: Assessing the role of MSH2 and MSH6 gene expression deficiency in prostate cancer progression, a cross-sectional study.
  2. LINC01232 targeting miR-1250-3p/MSH2 axis attenuates mesangial cell proliferation and fibrosis in diabetic nephropathy.
    Title: LINC01232 targeting miR-1250-3p/MSH2 axis attenuates mesangial cell proliferation and fibrosis in diabetic nephropathy.
  3. Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma.
    Title: Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma.
  4. Rare single-nucleotide variants of MLH1 and MSH2 genes in patients with Lynch syndrome.
    Title: Rare single-nucleotide variants of MLH1 and MSH2 genes in patients with Lynch syndrome.
  5. Role of MLH1 and MSH2 deficiency in the development of tumorigenesis and chemo-tolerance of cervical Carcinoma: Clinical implications.
    Title: Role of MLH1 and MSH2 deficiency in the development of tumorigenesis and chemo-tolerance of cervical Carcinoma: Clinical implications.
  6. Whole exome sequencing identifies MAP3K1, MSH2, and MLH1 as potential cancer-predisposing genes in familial early-onset colorectal cancer.
    Title: Whole exome sequencing identifies MAP3K1, MSH2, and MLH1 as potential cancer-predisposing genes in familial early-onset colorectal cancer.
  7. MiR-590-5p promotes cisplatin resistance via targeting hMSH2 in ovarian cancer.
    Title: MiR-590-5p promotes cisplatin resistance via targeting hMSH2 in ovarian cancer.
  8. MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1.
    Title: MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1.
  9. MSH2 is the very young onset ovarian cancer predisposition gene, not BRCA1.
    Title: MSH2 is the very young onset ovarian cancer predisposition gene, not BRCA1.
  10. Comprehensive RNA and protein functional assessments contribute to the clinical interpretation of MSH2 variants causing in-frame splicing alterations.
    Title: Comprehensive RNA and protein functional assessments contribute to the clinical interpretation of MSH2 variants causing in-frame splicing alterations.
Submit: New GeneRIF Correction See all GeneRIFs (538)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Professional guidelines

Description
Professional guideline
ACMG 2013

The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in MSH2 that are pathogenic or expected to be pathogenic.

GuidelinePubMed

Associated conditions

Description Tests
Lynch syndrome
MedGen: C4552100 GeneReviews: Lynch Syndrome
Compare labs
Lynch syndrome 1
MedGen: C2936783 OMIM: 120435 GeneReviews: Lynch Syndrome
Compare labs
Mismatch repair cancer syndrome 2
MedGen: C5436806 OMIM: 619096 GeneReviews: Not available
Compare labs
Muir-Torre syndrome
MedGen: C1321489 OMIM: 158320 GeneReviews: Lynch Syndrome
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2021-10-13)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2021-10-13)

ClinGen Genome Curation PagePubMed

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with mutS homolog 2, colon cancer, nonpolyposis type 1 (MSH2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ADP binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to MutLalpha complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables centromeric DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to dinucleotide insertion or deletion binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to dinucleotide repeat insertion binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to four-way junction DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to guanine/thymine mispair binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to guanine/thymine mispair binding IEA
Inferred from Electronic Annotation
more info
  
enables guanine/thymine mispair binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to mismatched DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to oxidized purine DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to single guanine insertion binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to single thymine insertion binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within B cell mediated immunity IEA
Inferred from Electronic Annotation
more info
  
involved_in B cell mediated immunity ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within determination of adult lifespan IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within germ cell development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within isotype switching IEA
Inferred from Electronic Annotation
more info
  
involved_in isotype switching ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in maintenance of DNA repeat elements IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within male gonad development IEA
Inferred from Electronic Annotation
more info
  
involved_in male gonad development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mismatch repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mismatch repair IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mismatch repair IEA
Inferred from Electronic Annotation
more info
  
involved_in mismatch repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mismatch repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within mitotic intra-S DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA recombination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of isotype switching to IgA isotypes IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of isotype switching to IgG isotypes IEA
Inferred from Electronic Annotation
more info
  
involved_in postreplication repair IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within postreplication repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to UV-B IEA
Inferred from Electronic Annotation
more info
  
involved_in response to UV-B ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within response to X-ray IEA
Inferred from Electronic Annotation
more info
  
involved_in response to X-ray ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within somatic hypermutation of immunoglobulin genes IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within somatic recombination of immunoglobulin gene segments IEA
Inferred from Electronic Annotation
more info
  
involved_in somatic recombination of immunoglobulin gene segments ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in somatic recombination of immunoglobulin genes involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within somatic recombination of immunoglobulin genes involved in immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of MutSalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MutSalpha complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MutSalpha complex IEA
Inferred from Electronic Annotation
more info
  
part_of MutSalpha complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of MutSbeta complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MutSbeta complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA mismatch repair protein Msh2
Names
DNA mismatch repair protein Msh2 transcript
MutS-like 2
mutS homolog 2, colon cancer, nonpolyposis type 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007110.2 RefSeqGene

    Range
    4944..85105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_218

mRNA and Protein(s)

  1. NM_000251.3 → NP_000242.1  DNA mismatch repair protein Msh2 isoform 1

    See identical proteins and their annotated locations for NP_000242.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK304496, CB250419, U04045
    Consensus CDS
    CCDS1834.1
    UniProtKB/Swiss-Prot
    B4E2Z2, O75488, P43246
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1
    Related
    ENSP00000233146.2, ENST00000233146.7
    Conserved Domains (1) summary
    COG0249
    Location:23 → 853
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]

  2. NM_001258281.1 → NP_001245210.1  DNA mismatch repair protein Msh2 isoform 2

    See identical proteins and their annotated locations for NP_001245210.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment of the first exon, including the translation start site, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK304496, CB250419, DC342099
    Consensus CDS
    CCDS58709.1
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1
    Related
    ENSP00000442697.1, ENST00000543555.6
    Conserved Domains (2) summary
    COG0249
    Location:58 → 787
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:5 → 66
    MutS_I; MutS domain I

  3. NM_001406631.1 → NP_001393560.1  DNA mismatch repair protein Msh2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  4. NM_001406632.1 → NP_001393561.1  DNA mismatch repair protein Msh2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  5. NM_001406633.1 → NP_001393562.1  DNA mismatch repair protein Msh2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  6. NM_001406634.1 → NP_001393563.1  DNA mismatch repair protein Msh2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  7. NM_001406635.1 → NP_001393564.1  DNA mismatch repair protein Msh2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  8. NM_001406636.1 → NP_001393565.1  DNA mismatch repair protein Msh2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  9. NM_001406637.1 → NP_001393566.1  DNA mismatch repair protein Msh2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC006509, AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  10. NM_001406638.1 → NP_001393567.1  DNA mismatch repair protein Msh2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  11. NM_001406639.1 → NP_001393568.1  DNA mismatch repair protein Msh2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  12. NM_001406640.1 → NP_001393569.1  DNA mismatch repair protein Msh2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  13. NM_001406641.1 → NP_001393570.1  DNA mismatch repair protein Msh2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/Swiss-Prot
    B4E2Z2, O75488, P43246
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  14. NM_001406642.1 → NP_001393571.1  DNA mismatch repair protein Msh2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  15. NM_001406643.1 → NP_001393572.1  DNA mismatch repair protein Msh2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  16. NM_001406644.1 → NP_001393573.1  DNA mismatch repair protein Msh2 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    Consensus CDS
    CCDS92750.1
    UniProtKB/TrEMBL
    A0A2R8Y6P0, Q53FK0, Q53GS1
    Related
    ENSP00000495455.1, ENST00000645506.1

  17. NM_001406645.1 → NP_001393574.1  DNA mismatch repair protein Msh2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/TrEMBL
    E9PHA6, Q53FK0, Q53GS1
    Related
    ENSP00000384199.1, ENST00000406134.5

  18. NM_001406646.1 → NP_001393575.1  DNA mismatch repair protein Msh2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655
    UniProtKB/TrEMBL
    A0A2R8YFH0, Q53FK0, Q53GS1
    Related
    ENSP00000496441.1, ENST00000645339.1

  19. NM_001406647.1 → NP_001393576.1  DNA mismatch repair protein Msh2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  20. NM_001406648.1 → NP_001393577.1  DNA mismatch repair protein Msh2 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/TrEMBL
    A0A2R8Y713, Q53FK0, Q53GS1
    Related
    ENSP00000495641.2, ENST00000644900.2

  21. NM_001406649.1 → NP_001393578.1  DNA mismatch repair protein Msh2 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/TrEMBL
    A0AAQ5BH31, Q53FK0, Q53GS1

  22. NM_001406650.1 → NP_001393579.1  DNA mismatch repair protein Msh2 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/TrEMBL
    A0AAQ5BH31, Q53FK0, Q53GS1
    Related
    ENSP00000519159.1, ENST00000713854.1

  23. NM_001406651.1 → NP_001393580.1  DNA mismatch repair protein Msh2 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  24. NM_001406652.1 → NP_001393581.1  DNA mismatch repair protein Msh2 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  25. NM_001406653.1 → NP_001393582.1  DNA mismatch repair protein Msh2 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  26. NM_001406654.1 → NP_001393583.1  DNA mismatch repair protein Msh2 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

  27. NM_001406655.1 → NP_001393584.1  DNA mismatch repair protein Msh2 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/TrEMBL
    Q53RU4

  28. NM_001406656.1 → NP_001393585.1  DNA mismatch repair protein Msh2 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/TrEMBL
    B4DL39, E9PBP1

  29. NM_001406657.1 → NP_001393586.1  DNA mismatch repair protein Msh2 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/TrEMBL
    A0A2R8Y7S8
    Related
    ENSP00000496351.1, ENST00000644092.1

  30. NM_001406658.1 → NP_001393587.1  DNA mismatch repair protein Msh2 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  31. NM_001406659.1 → NP_001393588.1  DNA mismatch repair protein Msh2 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  32. NM_001406660.1 → NP_001393589.1  DNA mismatch repair protein Msh2 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  33. NM_001406661.1 → NP_001393590.1  DNA mismatch repair protein Msh2 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  34. NM_001406662.1 → NP_001393591.1  DNA mismatch repair protein Msh2 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  35. NM_001406666.1 → NP_001393595.1  DNA mismatch repair protein Msh2 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC079775
    UniProtKB/TrEMBL
    V9H023
    Related
    ENSP00000519166.1, ENST00000713861.1

  36. NM_001406669.1 → NP_001393598.1  DNA mismatch repair protein Msh2 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  37. NM_001406672.1 → NP_001393601.1  DNA mismatch repair protein Msh2 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC079775
    UniProtKB/TrEMBL
    V9H023

  38. NM_001406674.1 → NP_001393603.1  DNA mismatch repair protein Msh2 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/TrEMBL
    Q53FK0, Q53GS1

RNA

  1. NR_176230.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  2. NR_176231.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  3. NR_176232.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  4. NR_176233.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  5. NR_176234.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  6. NR_176235.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  7. NR_176236.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  8. NR_176237.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  9. NR_176238.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  10. NR_176239.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  11. NR_176240.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  12. NR_176241.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  13. NR_176242.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  14. NR_176243.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  15. NR_176244.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  16. NR_176245.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  17. NR_176246.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  18. NR_176247.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  19. NR_176248.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  20. NR_176249.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  21. NR_176250.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    47403067..47709830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444416.1 → XP_047300372.1  DNA mismatch repair protein Msh2 isoform X1

    UniProtKB/TrEMBL
    A0A2R8YG02, Q53FK0, Q53GS1
    Related
    ENSP00000495543.1, ENST00000646415.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    47408101..47714827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43246.1 GenPept UniProtKB/Swiss-Prot:P43246

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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