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MSH2 mutS homolog 2 [ Homo sapiens (human) ]

Gene ID: 4436, updated on 9-Mar-2023

Summary

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Official Symbol
MSH2provided by HGNC
Official Full Name
mutS homolog 2provided by HGNC
Primary source
HGNC:HGNC:7325
See related
Ensembl:ENSG00000095002 MIM:609309; AllianceGenome:HGNC:7325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FCC1; COCA1; HNPCC; LCFS2; MSH-2; hMSH2; HNPCC1; LYNCH1; MMRCS2
Summary
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Expression
Ubiquitous expression in lymph node (RPKM 3.7), testis (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

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See MSH2 in Genome Data Viewer
Location:
2p21-p16.3
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (47403067..47634501)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (47408101..47488281)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (47630206..47710367)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 119 Neighboring gene epithelial cell adhesion molecule Neighboring gene microRNA 559 Neighboring gene potassium two pore domain channel subfamily K member 12 Neighboring gene MSH2 overlapping transcript 1 Neighboring gene Sharpr-MPRA regulatory region 1309 Neighboring gene uncharacterized LOC124907764 Neighboring gene ribosomal protein L18a pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High MutS homolog 2 expression predicts poor prognosis and is related to immune infiltration in endometrial carcinoma. Lu X, et al. Cell Biol Int, 2023 Jan. PMID 36208091
  2. Genetic polymorphisms in the mismatch repair pathway (MMR) genes contribute to hematological and gastrointestinal toxicity in North Indian lung cancer patients treated with platinum-based chemotherapy. Singh S, et al. J Biochem Mol Toxicol, 2022 Nov. PMID 35924411
  3. RNA sequencing uncovers clinically actionable germline intronic MSH2 variants in previously unresolved Lynch syndrome families. Fulk K, et al. BMJ Case Rep, 2022 Apr 29. PMID 35487642,
  4. Identification of SNPs in hMSH3/MSH6 interaction domain affecting the structure and function of MSH2 protein. Singh S, et al. Biotechnol Appl Biochem, 2022 Dec. PMID 34837403
  5. A novel Lynch syndrome pedigree bearing germ-line MSH2 missense mutation c.1808A>T (Asp603Val). Sekine R, et al. Jpn J Clin Oncol, 2022 Jan 3. PMID 34761252

See all (886) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of SNPs in hMSH3/MSH6 interaction domain affecting the structure and function of MSH2 protein.
    Title: Identification of SNPs in hMSH3/MSH6 interaction domain affecting the structure and function of MSH2 protein.
  2. High MutS homolog 2 expression predicts poor prognosis and is related to immune infiltration in endometrial carcinoma.
    Title: High MutS homolog 2 expression predicts poor prognosis and is related to immune infiltration in endometrial carcinoma.
  3. Genetic polymorphisms in the mismatch repair pathway (MMR) genes contribute to hematological and gastrointestinal toxicity in North Indian lung cancer patients treated with platinum-based chemotherapy.
    Title: Genetic polymorphisms in the mismatch repair pathway (MMR) genes contribute to hematological and gastrointestinal toxicity in North Indian lung cancer patients treated with platinum-based chemotherapy.
  4. Teenage-Onset Colorectal Cancers in a Digenic Cancer Predisposition Syndrome Provide Clues for the Interaction between Mismatch Repair and Polymerase delta Proofreading Deficiency in Tumorigenesis.
    Title: Teenage-Onset Colorectal Cancers in a Digenic Cancer Predisposition Syndrome Provide Clues for the Interaction between Mismatch Repair and Polymerase δ Proofreading Deficiency in Tumorigenesis.
  5. Germline variants screening of MLH1, MSH2, MSH6 and PMS2 genes in 64 Algerian Lynch syndrome families: The first nationwide study.
    Title: Germline variants screening of MLH1, MSH2, MSH6 and PMS2 genes in 64 Algerian Lynch syndrome families: The first nationwide study.
  6. DNA methylation status of MutS genes in ameloblastoma.
    Title: DNA methylation status of MutS genes in ameloblastoma.
  7. CircWDR26 regulates endometrial carcinoma progression via miR-212-3p-mediated typing genes MSH2.
    Title: CircWDR26 regulates endometrial carcinoma progression via miR-212-3p-mediated typing genes MSH2.
  8. RNA sequencing uncovers clinically actionable germline intronic MSH2 variants in previously unresolved Lynch syndrome families.
    Title: RNA sequencing uncovers clinically actionable germline intronic MSH2 variants in previously unresolved Lynch syndrome families.
  9. Germline mutations in Chinese ovarian cancer with or without breast cancer.
    Title: Germline mutations in Chinese ovarian cancer with or without breast cancer.
  10. FAT1 and MSH2 Are Predictive Prognostic Markers for Chinese Osteosarcoma Patients Following Chemotherapeutic Treatment.
    Title: FAT1 and MSH2 Are Predictive Prognostic Markers for Chinese Osteosarcoma Patients Following Chemotherapeutic Treatment.
Submit: New GeneRIF Correction See all GeneRIFs (527)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Professional guidelines

Description
Professional guideline
ACMG 2013

The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in MSH2 that are pathogenic or expected to be pathogenic.

GuidelinePubMed

Associated conditions

Description Tests
Lynch syndrome
MedGen: C4552100 GeneReviews: Lynch Syndrome
Compare labs
Lynch syndrome 1
MedGen: C2936783 OMIM: 120435 GeneReviews: Lynch Syndrome
Compare labs
Mismatch repair cancer syndrome 2
MedGen: C5436806 OMIM: 619096 GeneReviews: Not available
Compare labs
Muir-Torre syndrome
MedGen: C1321489 OMIM: 158320 GeneReviews: Lynch Syndrome
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2021-10-13)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2021-10-13)

ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with mutS homolog 2, colon cancer, nonpolyposis type 1 (MSH2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ADP binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to MutLalpha complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables centromeric DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to dinucleotide insertion or deletion binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to dinucleotide repeat insertion binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to four-way junction DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to guanine/thymine mispair binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanine/thymine mispair binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to mismatched DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to oxidized purine DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to single guanine insertion binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to single thymine insertion binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in B cell mediated immunity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in determination of adult lifespan IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
involved_in germ cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
Inferred from Electronic Annotation
more info
  
involved_in isotype switching ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in maintenance of DNA repeat elements IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male gonad development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within mismatch repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mismatch repair IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mismatch repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic intra-S DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in negative regulation of DNA recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of isotype switching to IgA isotypes IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of isotype switching to IgG isotypes IEA
Inferred from Electronic Annotation
more info
  
involved_in postreplication repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to chromatin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to UV-B ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to X-ray ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in somatic hypermutation of immunoglobulin genes IEA
Inferred from Electronic Annotation
more info
  
involved_in somatic recombination of immunoglobulin gene segments ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in somatic recombination of immunoglobulin genes involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
part_of MutSalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of MutSalpha complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MutSalpha complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of MutSbeta complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MutSbeta complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome, telomeric region HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA mismatch repair protein Msh2
Names
DNA mismatch repair protein Msh2 transcript
MutS-like 2
mutS homolog 2, colon cancer, nonpolyposis type 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007110.2 RefSeqGene

    Range
    4944..85105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_218

mRNA and Protein(s)

  1. NM_000251.3 → NP_000242.1  DNA mismatch repair protein Msh2 isoform 1

    See identical proteins and their annotated locations for NP_000242.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK304496, CB250419, U04045
    Consensus CDS
    CCDS1834.1
    UniProtKB/Swiss-Prot
    O75488, P43246
    Related
    ENSP00000233146.2, ENST00000233146.7
    Conserved Domains (1) summary
    COG0249
    Location:23 → 853
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]

  2. NM_001258281.1 → NP_001245210.1  DNA mismatch repair protein Msh2 isoform 2

    See identical proteins and their annotated locations for NP_001245210.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment of the first exon, including the translation start site, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK304496, CB250419, DC342099
    Consensus CDS
    CCDS58709.1
    UniProtKB/Swiss-Prot
    P43246
    Related
    ENSP00000442697.1, ENST00000543555.6
    Conserved Domains (2) summary
    COG0249
    Location:58 → 787
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:5 → 66
    MutS_I; MutS domain I

  3. NM_001406631.1 → NP_001393560.1  DNA mismatch repair protein Msh2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  4. NM_001406632.1 → NP_001393561.1  DNA mismatch repair protein Msh2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  5. NM_001406633.1 → NP_001393562.1  DNA mismatch repair protein Msh2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  6. NM_001406634.1 → NP_001393563.1  DNA mismatch repair protein Msh2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  7. NM_001406635.1 → NP_001393564.1  DNA mismatch repair protein Msh2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  8. NM_001406636.1 → NP_001393565.1  DNA mismatch repair protein Msh2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  9. NM_001406637.1 → NP_001393566.1  DNA mismatch repair protein Msh2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC006509, AC079775, AC138655

  10. NM_001406638.1 → NP_001393567.1  DNA mismatch repair protein Msh2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  11. NM_001406639.1 → NP_001393568.1  DNA mismatch repair protein Msh2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  12. NM_001406640.1 → NP_001393569.1  DNA mismatch repair protein Msh2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  13. NM_001406641.1 → NP_001393570.1  DNA mismatch repair protein Msh2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/Swiss-Prot
    O75488

  14. NM_001406642.1 → NP_001393571.1  DNA mismatch repair protein Msh2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  15. NM_001406643.1 → NP_001393572.1  DNA mismatch repair protein Msh2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  16. NM_001406644.1 → NP_001393573.1  DNA mismatch repair protein Msh2 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    Consensus CDS
    CCDS92750.1
    UniProtKB/TrEMBL
    A0A2R8Y6P0

  17. NM_001406645.1 → NP_001393574.1  DNA mismatch repair protein Msh2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655
    UniProtKB/TrEMBL
    E9PHA6

  18. NM_001406646.1 → NP_001393575.1  DNA mismatch repair protein Msh2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655
    UniProtKB/TrEMBL
    A0A2R8YFH0

  19. NM_001406647.1 → NP_001393576.1  DNA mismatch repair protein Msh2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  20. NM_001406648.1 → NP_001393577.1  DNA mismatch repair protein Msh2 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  21. NM_001406649.1 → NP_001393578.1  DNA mismatch repair protein Msh2 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  22. NM_001406650.1 → NP_001393579.1  DNA mismatch repair protein Msh2 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  23. NM_001406651.1 → NP_001393580.1  DNA mismatch repair protein Msh2 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  24. NM_001406652.1 → NP_001393581.1  DNA mismatch repair protein Msh2 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  25. NM_001406653.1 → NP_001393582.1  DNA mismatch repair protein Msh2 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  26. NM_001406654.1 → NP_001393583.1  DNA mismatch repair protein Msh2 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  27. NM_001406655.1 → NP_001393584.1  DNA mismatch repair protein Msh2 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  28. NM_001406656.1 → NP_001393585.1  DNA mismatch repair protein Msh2 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  29. NM_001406657.1 → NP_001393586.1  DNA mismatch repair protein Msh2 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  30. NM_001406658.1 → NP_001393587.1  DNA mismatch repair protein Msh2 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  31. NM_001406659.1 → NP_001393588.1  DNA mismatch repair protein Msh2 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  32. NM_001406660.1 → NP_001393589.1  DNA mismatch repair protein Msh2 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  33. NM_001406661.1 → NP_001393590.1  DNA mismatch repair protein Msh2 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  34. NM_001406662.1 → NP_001393591.1  DNA mismatch repair protein Msh2 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  35. NM_001406666.1 → NP_001393595.1  DNA mismatch repair protein Msh2 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC079775

  36. NM_001406669.1 → NP_001393598.1  DNA mismatch repair protein Msh2 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  37. NM_001406672.1 → NP_001393601.1  DNA mismatch repair protein Msh2 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC079775

  38. NM_001406674.1 → NP_001393603.1  DNA mismatch repair protein Msh2 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

RNA

  1. NR_176230.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  2. NR_176231.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  3. NR_176232.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  4. NR_176233.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  5. NR_176234.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  6. NR_176235.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  7. NR_176236.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  8. NR_176237.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  9. NR_176238.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  10. NR_176239.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  11. NR_176240.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  12. NR_176241.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  13. NR_176242.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  14. NR_176243.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  15. NR_176244.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  16. NR_176245.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  17. NR_176246.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  18. NR_176247.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  19. NR_176248.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079250, AC079775, AC138655

  20. NR_176249.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

  21. NR_176250.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079775, AC138655

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    47403067..47634501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444416.1 → XP_047300372.1  DNA mismatch repair protein Msh2 isoform X2

    UniProtKB/TrEMBL
    A0A2R8YG02
    Related
    ENSP00000495543.1, ENST00000646415.1

  2. XM_011532867.3 → XP_011531169.1  DNA mismatch repair protein Msh2 isoform X3

    Related
    ENSP00000495455.1, ENST00000645506.1
    Conserved Domains (6) summary
    cd03285
    Location:633 → 852
    ABC_MSH2_euk; ATP-binding cassette domain of eukaryotic MutS2 homolog
    COG0249
    Location:23 → 853
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:18 → 132
    MutS_I; MutS domain I
    pfam05188
    Location:158 → 284
    MutS_II; MutS domain II
    pfam05190
    Location:473 → 569
    MutS_IV; MutS family domain IV
    pfam05192
    Location:305 → 423
    MutS_III; MutS domain III

  3. XM_005264332.5 → XP_005264389.2  DNA mismatch repair protein Msh2 isoform X1

    Conserved Domains (6) summary
    cd03285
    Location:633 → 852
    ABC_MSH2_euk; ATP-binding cassette domain of eukaryotic MutS2 homolog
    COG0249
    Location:23 → 853
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:18 → 132
    MutS_I; MutS domain I
    pfam05188
    Location:158 → 284
    MutS_II; MutS domain II
    pfam05190
    Location:473 → 569
    MutS_IV; MutS family domain IV
    pfam05192
    Location:305 → 423
    MutS_III; MutS domain III

RNA

  1. XR_001738747.3 RNA Sequence

  2. XR_939685.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    47408101..47488281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43246.1 GenPept UniProtKB/Swiss-Prot:P43246

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