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mcm-10 Protein MCM10 homolog [ Caenorhabditis elegans ]

Gene ID: 176562, updated on 23-Nov-2023

Summary

Gene symbol
mcm-10
Gene description
Protein MCM10 homolog
Primary source
WormBase:WBGene00012935
Locus tag
CELE_Y47D3A.28
See related
AllianceGenome:WB:WBGene00012935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA replication origin binding activity and single-stranded DNA binding activity. Predicted to be involved in DNA replication initiation. Predicted to be located in nucleus. Predicted to be part of replication fork protection complex. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MCM10 (minichromosome maintenance 10 replication initiation factor). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See mcm-10 in Genome Data Viewer
Location:
chromosome: III
Exon count:
14
Sequence:
Chromosome: III; NC_003281.10 (11317570..11326664)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Ras-related protein Rab-35 Neighboring gene GYF domain-containing protein Neighboring gene GTP-binding protein 128up;OBG-type G domain-containing protein Neighboring gene CUB domain-containing protein Neighboring gene START domain-containing protein Neighboring gene Gamma-secretase subunit pen-2

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nuclear replication fork IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Protein MCM10 homolog
NP_499456.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11317570..11326664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067055.4NP_499456.1  Protein MCM10 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499456.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U2C2
    Conserved Domains (2) summary
    pfam09329
    Location:258304
    zf-primase; Primase zinc finger
    pfam09332
    Location:365691
    Mcm10; Mcm10 replication factor