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ttll-4 Tubulin polyglutamylase ttll-4 [ Caenorhabditis elegans ]

Gene ID: 176427, updated on 18-Sep-2024

Summary

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Official Symbol
ttll-4
Official Full Name
Tubulin polyglutamylase ttll-4
Primary source
WormBase:WBGene00014232
Locus tag
CELE_ZK1128.6
See related
AllianceGenome:WB:WBGene00014232
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables tubulin-glutamic acid ligase activity. Involved in protein polyglutamylation and response to hermaphrodite contact. Predicted to be active in cilium. Orthologous to human TTLL4 (tubulin tyrosine ligase like 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (10124183..10132411)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene General transcription factor IIH subunit 3 Neighboring gene SWI/SNF chromatin-remodeling accessory subunit 1 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Environmental responsiveness of tubulin glutamylation in sensory cilia is regulated by the p38 MAPK pathway. Kimura Y, et al. Sci Rep, 2018 May 30. PMID 29849065, Free PMC Article
  2. Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes. Mahalingan KK, et al. Nat Struct Mol Biol, 2020 Sep. PMID 32747782
  3. Caenorhabditis elegans glutamylating enzymes function redundantly in male mating. Chawla DG, et al. Biol Open, 2016 Sep 15. PMID 27635036, Free PMC Article
  4. The tubulin deglutamylase CCPP-1 regulates the function and stability of sensory cilia in C. elegans. O'Hagan R, et al. Curr Biol, 2011 Oct 25. PMID 21982591, Free PMC Article
  5. Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function. Power KM, et al. PLoS Genet, 2020 Oct. PMID 33064774, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.
    Title: Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-glutamic acid ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tubulin-glutamic acid ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyglutamylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reproductive behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hermaphrodite contact IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tubulin polyglutamylase ttll-4
NP_001022985.1
  • Confirmed by transcript evidence
NP_001022986.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10124183..10132411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027814.4 → NP_001022985.1  Tubulin polyglutamylase ttll-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022985.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09647, Q5FC81
    Conserved Domains (1) summary
    pfam03133
    Location:189 → 474
    TTL; Tubulin-tyrosine ligase family

  2. NM_001027815.6 → NP_001022986.1  Tubulin polyglutamylase ttll-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022986.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09647
    Conserved Domains (1) summary
    pfam03133
    Location:151 → 436
    TTL; Tubulin-tyrosine ligase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09647.3

Gene LinkOut

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