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hadb-1 putative 3-ketoacyl-CoA thiolase [ Caenorhabditis elegans ]

Gene ID: 176216, updated on 23-Nov-2023

Summary

Gene symbol
hadb-1
Gene description
putative 3-ketoacyl-CoA thiolase
Primary source
WormBase:WBGene00015125
Locus tag
CELE_B0303.3
See related
AllianceGenome:WB:WBGene00015125
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable acetyl-CoA C-acyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion. Is expressed in body wall musculature; hypodermis; intestine; and tail. Human ortholog(s) of this gene implicated in mitochondrial metabolism disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See hadb-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (8686359..8688166, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene P granule abnormality protein 2 Neighboring gene pseudo Neighboring gene Protein flightless-1 homolog Neighboring gene ncRNA Neighboring gene tRNA-Trp Neighboring gene Nicotinamide N-methyltransferase Neighboring gene Uncharacterized protein Neighboring gene SH3 domain-containing protein Neighboring gene Skn-1 dependent zygotic transcript 1 protein

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acetyl-CoA C-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative 3-ketoacyl-CoA thiolase
NP_498915.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8686359..8688166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066514.8NP_498915.1  putative 3-ketoacyl-CoA thiolase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498915.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34255
    Conserved Domains (2) summary
    cd00751
    Location:27445
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
    TIGR01930
    Location:29444
    AcCoA-C-Actrans; acetyl-CoA acetyltransferases