U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

alh-1 Aldedh domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175691, updated on 5-Jun-2022

Summary

Gene symbol
alh-1
Gene description
Aldedh domain-containing protein
Primary source
WormBase:WBGene00000107
Locus tag
CELE_F54D8.3
See related
AllianceGenome:WB:WBGene00000107
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable aldehyde dehydrogenase (NAD+) activity. Is expressed in head mesodermal cell; intestine; nervous system; pharynx; and rectal gland cell. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); diabetic neuropathy; and liver disease (multiple). Orthologous to several human genes including ALDH1B1 (aldehyde dehydrogenase 1 family member B1) and ALDH2 (aldehyde dehydrogenase 2 family member). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See alh-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (5077764..5080661)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative tRNA-dihydrouridine synthase-like protein C45G9.2 Neighboring gene Uncharacterized protein Neighboring gene Inactive tau-tubulin kinase ttbk-6 Neighboring gene ncRNA Neighboring gene Cytochrome c oxidase subunit 6A, mitochondrial

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the alh-1 gene: The alh-1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.
  • Orthologs

General protein information

Preferred Names
Aldedh domain-containing protein
NP_001379805.1
  • Confirmed by transcript evidence
NP_498081.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5077764..5080661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392085.1NP_001379805.1  Aldedh domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd07091
    Location:1415
    ALDH_F1-2_Ald2-like; ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins
  2. NM_065680.8NP_498081.2  Aldedh domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498081.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20780
    Conserved Domains (1) summary
    cd07141
    Location:24504
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like