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nduc-2 NADH dehydrogenase [ubiquinone] 1 subunit C2 [ Caenorhabditis elegans ]

Gene ID: 175397, updated on 18-Sep-2024

Summary

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Official Symbol
nduc-2
Official Full Name
NADH dehydrogenase [ubiquinone] 1 subunit C2
Primary source
WormBase:WBGene00022169
Locus tag
CELE_Y71H2AM.4
See related
AllianceGenome:WB:WBGene00022169
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be integral component of membrane. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency. Orthologous to several human genes including NDUFC2 (NADH:ubiquinone oxidoreductase subunit C2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003281.10 (2786852..2788028)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DNA/pantothenate metabolism flavoprotein C-terminal domain-containing protein;Myotubularin phosphatase domain-containing protein Neighboring gene Serine/threonine-protein phosphatase 2A activator Neighboring gene Cytochrome oxidase c subunit VIb Neighboring gene C-CAP/cofactor C-like domain-containing protein Neighboring gene Potassium channel domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 subunit C2
NP_001380068.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    2786852..2788028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393299.1 → NP_001380068.1  NADH dehydrogenase [ubiquinone] 1 subunit C2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BL33
    Conserved Domains (1) summary
    pfam06374
    Location:31 → 132
    NDUF_C2; NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)
Nucleotide Protein
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