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Meis3 Meis homeobox 3 [ Mus musculus (house mouse) ]

Gene ID: 17537, updated on 8-May-2024

Summary

Official Symbol
Meis3provided by MGI
Official Full Name
Meis homeobox 3provided by MGI
Primary source
MGI:MGI:108519
See related
Ensembl:ENSMUSG00000041420 AllianceGenome:MGI:108519
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mrg2
Summary
The protein encoding this gene belongs to the three amino acid loop extension family of homeodomain transcription factors, which play essential roles in many embryonic processes. These proteins are characterized by an atypical homeodomain containing a three amino acid loop extension between helices 1 and 2. Expression of this gene begins during the compaction stage of embryogenesis and continues into the blastocyst stage. This gene is also expressed in pancreatic islet cells and beta-cells and regulates beta-cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Expression
Broad expression in whole brain E14.5 (RPKM 38.1), CNS E14 (RPKM 35.8) and 21 other tissues See more
Orthologs
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Genomic context

See Meis3 in Genome Data Viewer
Location:
7 A2; 7 8.76 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (15908684..15920435)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16174012..16186510)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6515 Neighboring gene kaptin Neighboring gene solute carrier family 8 (sodium/calcium exchanger), member 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:16786573-16786682 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:16792577-16792686 Neighboring gene DExH-box helicase 34 Neighboring gene STARR-positive B cell enhancer ABC_E1334 Neighboring gene STARR-seq mESC enhancer starr_18126 Neighboring gene predicted gene, 26473 Neighboring gene complement component 5a receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC144812, MGC144813

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeobox protein Meis3
Names
meis1-related protein 2
myeloid ecotropic viral integration site-related gene 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277988.3NP_001264917.1  homeobox protein Meis3 isoform b

    See identical proteins and their annotated locations for NP_001264917.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, and 6 all encode the same isoform (b).
    Source sequence(s)
    AC156630
    Consensus CDS
    CCDS71892.1
    UniProtKB/TrEMBL
    Q3U2C1
    Conserved Domains (2) summary
    pfam05920
    Location:266305
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99166
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  2. NM_001277989.3NP_001264918.1  homeobox protein Meis3 isoform b

    See identical proteins and their annotated locations for NP_001264918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 5' end of an exon and differs in the 3' UTR compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, and 6 all encode the same isoform (b).
    Source sequence(s)
    AC156630
    Consensus CDS
    CCDS71892.1
    UniProtKB/TrEMBL
    Q3U2C1
    Related
    ENSMUSP00000134918.2, ENSMUST00000176506.8
    Conserved Domains (2) summary
    pfam05920
    Location:266305
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99166
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  3. NM_001302472.2NP_001289401.1  homeobox protein Meis3 isoform a

    See identical proteins and their annotated locations for NP_001289401.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR compared to variant 1. Variants 1 and 5 both encode the same isoform (a).
    Source sequence(s)
    AC156630
    Consensus CDS
    CCDS39782.1
    UniProtKB/Swiss-Prot
    P97368, Q149R5, Q99L81
    UniProtKB/TrEMBL
    Q3U2C1
    Conserved Domains (2) summary
    pfam05920
    Location:283322
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99183
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  4. NM_001417025.1NP_001403954.1  homeobox protein Meis3 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC156630
  5. NM_001417026.1NP_001403955.1  homeobox protein Meis3 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC156630
  6. NM_008627.5NP_032653.2  homeobox protein Meis3 isoform a

    See identical proteins and their annotated locations for NP_032653.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 5 both encode the same isoform (a).
    Source sequence(s)
    AC156630
    Consensus CDS
    CCDS39782.1
    UniProtKB/Swiss-Prot
    P97368, Q149R5, Q99L81
    UniProtKB/TrEMBL
    Q3U2C1
    Related
    ENSMUSP00000002495.11, ENSMUST00000002495.18
    Conserved Domains (2) summary
    pfam05920
    Location:283322
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99183
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RNA

  1. NR_102730.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and uses an alternate splice junction at the 3' end of an exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC156630
    Related
    ENSMUST00000177156.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    15908684..15920435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539603.5XP_006539666.1  homeobox protein Meis3 isoform X3

    See identical proteins and their annotated locations for XP_006539666.1

    UniProtKB/Swiss-Prot
    P97368, Q149R5, Q99L81
    UniProtKB/TrEMBL
    Q3U2C1
    Conserved Domains (2) summary
    pfam05920
    Location:283322
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99183
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  2. XM_036152757.1XP_036008650.1  homeobox protein Meis3 isoform X14

    Conserved Domains (2) summary
    pfam05920
    Location:216255
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99135
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  3. XM_036152746.1XP_036008639.1  homeobox protein Meis3 isoform X4

    UniProtKB/TrEMBL
    Q148B2
    Conserved Domains (2) summary
    pfam05920
    Location:305344
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99205
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  4. XM_036152756.1XP_036008649.1  homeobox protein Meis3 isoform X13

    UniProtKB/TrEMBL
    Q3U2C1
    Conserved Domains (2) summary
    pfam05920
    Location:233272
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99152
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  5. XM_036152753.1XP_036008646.1  homeobox protein Meis3 isoform X10

    UniProtKB/TrEMBL
    Q148B2
    Conserved Domains (2) summary
    pfam05920
    Location:266305
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99166
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  6. XM_036152751.1XP_036008644.1  homeobox protein Meis3 isoform X8

    UniProtKB/TrEMBL
    Q148B2
    Conserved Domains (2) summary
    pfam05920
    Location:283322
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99183
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  7. XM_036152748.1XP_036008641.1  homeobox protein Meis3 isoform X7

    UniProtKB/TrEMBL
    Q3U2C1
    Conserved Domains (2) summary
    pfam05920
    Location:255294
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99174
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  8. XM_036152750.1XP_036008643.1  homeobox protein Meis3 isoform X8

    UniProtKB/TrEMBL
    Q148B2
    Conserved Domains (2) summary
    pfam05920
    Location:283322
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99183
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  9. XM_036152744.1XP_036008637.1  homeobox protein Meis3 isoform X1

    UniProtKB/TrEMBL
    Q3U2C1
    Conserved Domains (2) summary
    pfam05920
    Location:305344
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99205
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  10. XM_036152749.1XP_036008642.1  homeobox protein Meis3 isoform X8

    UniProtKB/TrEMBL
    Q148B2
    Conserved Domains (2) summary
    pfam05920
    Location:283322
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99183
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  11. XM_036152745.1XP_036008638.1  homeobox protein Meis3 isoform X2

    UniProtKB/TrEMBL
    Q3U2C1
    Conserved Domains (2) summary
    pfam05920
    Location:288327
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99188
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  12. XM_036152743.1XP_036008636.1  homeobox protein Meis3 isoform X1

    UniProtKB/TrEMBL
    Q3U2C1
    Conserved Domains (2) summary
    pfam05920
    Location:305344
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99205
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  13. XM_030242197.2XP_030098057.1  homeobox protein Meis3 isoform X11

    UniProtKB/TrEMBL
    Q3U2C1
    Conserved Domains (2) summary
    pfam05920
    Location:233272
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99152
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  14. XM_036152755.1XP_036008648.1  homeobox protein Meis3 isoform X12

    UniProtKB/TrEMBL
    Q3U2C1
    Conserved Domains (2) summary
    pfam05920
    Location:216255
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99135
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  15. XM_036152747.1XP_036008640.1  homeobox protein Meis3 isoform X5

    UniProtKB/TrEMBL
    Q3U2C1
    Conserved Domains (2) summary
    pfam05920
    Location:266305
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99166
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  16. XM_036152752.1XP_036008645.1  homeobox protein Meis3 isoform X9

    UniProtKB/TrEMBL
    Q3U2C1
    Conserved Domains (2) summary
    pfam05920
    Location:249288
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99149
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  17. XM_036152754.1XP_036008647.1  homeobox protein Meis3 isoform X11

    UniProtKB/TrEMBL
    Q3U2C1
    Conserved Domains (2) summary
    pfam05920
    Location:233272
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99152
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  18. XM_006539605.5XP_006539668.1  homeobox protein Meis3 isoform X6

    UniProtKB/TrEMBL
    Q3U2C1
    Conserved Domains (2) summary
    pfam05920
    Location:266305
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99166
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  19. XM_030242194.2XP_030098054.1  homeobox protein Meis3 isoform X3

    UniProtKB/Swiss-Prot
    P97368, Q149R5, Q99L81
    UniProtKB/TrEMBL
    Q3U2C1
    Conserved Domains (2) summary
    pfam05920
    Location:283322
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99183
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  20. XM_030242195.2XP_030098055.1  homeobox protein Meis3 isoform X5

    UniProtKB/TrEMBL
    Q3U2C1
    Conserved Domains (2) summary
    pfam05920
    Location:266305
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99166
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  21. XM_030242198.2XP_030098058.1  homeobox protein Meis3 isoform X15

    Conserved Domains (2) summary
    pfam05920
    Location:156195
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:2656
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RNA

  1. XR_004934026.1 RNA Sequence

  2. XR_004934025.1 RNA Sequence

  3. XR_004934027.1 RNA Sequence

  4. XR_004934028.1 RNA Sequence