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MEIS3 Meis homeobox 3 [ Homo sapiens (human) ]

Gene ID: 56917, updated on 10-Oct-2024

Summary

Official Symbol
MEIS3provided by HGNC
Official Full Name
Meis homeobox 3provided by HGNC
Primary source
HGNC:HGNC:29537
See related
Ensembl:ENSG00000105419 MIM:619443; AllianceGenome:HGNC:29537
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRG2
Summary
This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells. [provided by RefSeq, Sep 2016]
Expression
Biased expression in endometrium (RPKM 15.5), brain (RPKM 9.1) and 10 other tissues See more
Orthologs
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Genomic context

See MEIS3 in Genome Data Viewer
Location:
19q13.32
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (47403124..47422233, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (50228571..50253087, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47906381..47925490, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4678 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47852412-47853316 Neighboring gene complement C5a receptor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47858319-47858818 Neighboring gene DExH-box helicase 34 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:47895565-47896211 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:47896212-47896859 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47901415-47902082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47905147-47905846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47905847-47906546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47906547-47907244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47920878-47921870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47921871-47922864 Neighboring gene hESC enhancers GRCh37_chr19:47931091-47931659 and GRCh37_chr19:47931660-47932227 Neighboring gene Sharpr-MPRA regulatory region 169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47939851-47940352 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:47945299-47945446 Neighboring gene solute carrier family 8 member A2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47949904-47950829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47971701-47972200 Neighboring gene Sharpr-MPRA regulatory region 3844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14866 Neighboring gene NAPA antisense RNA 1 Neighboring gene kaptin, actin binding protein Neighboring gene NSF attachment protein alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp547H236

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in embryonic pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in eye development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
homeobox protein Meis3
Names
Meis1, myeloid ecotropic viral integration site 1 homolog 3
meis1-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051644.1 RefSeqGene

    Range
    7707..24110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001009813.3NP_001009813.1  homeobox protein Meis3 isoform 2

    See identical proteins and their annotated locations for NP_001009813.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses alternate in-frame acceptor splice sites at two internal exon junctions compared to variant 1, which results in a shorter isoform (2) missing two internal protein segments compared to isoform 1.
    Source sequence(s)
    AL537583, BC069251, CF993984
    Consensus CDS
    CCDS46132.1
    UniProtKB/Swiss-Prot
    A8K0S8
    Related
    ENSP00000388667.2, ENST00000441740.6
    Conserved Domains (2) summary
    pfam05920
    Location:263302
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96162
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  2. NM_001301059.2NP_001287988.1  homeobox protein Meis3 isoform 3

    See identical proteins and their annotated locations for NP_001287988.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AL537583, BC045741, BI522513, BM783223, CF993984
    Consensus CDS
    CCDS74406.1
    UniProtKB/Swiss-Prot
    A8K0S8, A8K1N5, Q6NT73, Q8TC66, Q99687, Q9NPW2
    Related
    ENSP00000454073.1, ENST00000558555.6
    Conserved Domains (2) summary
    pfam05920
    Location:280319
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96179
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  3. NM_001346148.2NP_001333077.1  homeobox protein Meis3 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC073548
    UniProtKB/Swiss-Prot
    A8K0S8
  4. NM_020160.3NP_064545.1  homeobox protein Meis3 isoform 1

    See identical proteins and their annotated locations for NP_064545.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL537583, BC025404, CF993984, DB545063
    Consensus CDS
    CCDS33064.1
    UniProtKB/Swiss-Prot
    A8K0S8
    Related
    ENSP00000453307.1, ENST00000561293.5
    Conserved Domains (2) summary
    pfam05920
    Location:329365
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96179
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    47403124..47422233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451615.2XP_024307383.1  homeobox protein Meis3 isoform X4

    UniProtKB/Swiss-Prot
    A8K0S8
    Conserved Domains (2) summary
    pfam05920
    Location:326362
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:93176
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  2. XM_024451616.2XP_024307384.1  homeobox protein Meis3 isoform X6

    UniProtKB/Swiss-Prot
    A8K0S8
    UniProtKB/TrEMBL
    H3BLU4
    Related
    ENSP00000333552.4, ENST00000331559.9
    Conserved Domains (2) summary
    pfam05920
    Location:312348
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96162
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  3. XM_024451617.2XP_024307385.1  homeobox protein Meis3 isoform X7

    Related
    ENST00000561204.5
    Conserved Domains (2) summary
    pfam05920
    Location:197233
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:147
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  4. XM_017027011.2XP_016882500.1  homeobox protein Meis3 isoform X5

    UniProtKB/TrEMBL
    H0YNA8
    Related
    ENSP00000453934.1, ENST00000561096.5
  5. XM_024451613.2XP_024307381.1  homeobox protein Meis3 isoform X2

    Conserved Domains (2) summary
    pfam05920
    Location:400436
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:184250
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  6. XM_024451612.2XP_024307380.1  homeobox protein Meis3 isoform X1

    Conserved Domains (2) summary
    pfam05920
    Location:417453
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:184267
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  7. XM_011527136.4XP_011525438.1  homeobox protein Meis3 isoform X3

    Conserved Domains (2) summary
    pfam05920
    Location:351390
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:184250
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  8. XM_047439109.1XP_047295065.1  homeobox protein Meis3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    50228571..50253087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321499.1XP_054177474.1  homeobox protein Meis3 isoform X4

  2. XM_054321501.1XP_054177476.1  homeobox protein Meis3 isoform X6

    UniProtKB/TrEMBL
    H3BLU4
  3. XM_054321502.1XP_054177477.1  homeobox protein Meis3 isoform X7

  4. XM_054321500.1XP_054177475.1  homeobox protein Meis3 isoform X5

    UniProtKB/TrEMBL
    H0YNA8
  5. XM_054321497.1XP_054177472.1  homeobox protein Meis3 isoform X2

  6. XM_054321495.1XP_054177470.1  homeobox protein Meis3 isoform X1

  7. XM_054321498.1XP_054177473.1  homeobox protein Meis3 isoform X3

  8. XM_054321496.1XP_054177471.1  homeobox protein Meis3 isoform X1