Format

Send to:

Choose Destination

MEIS3 Meis homeobox 3 [ Homo sapiens (human) ]

Gene ID: 56917, updated on 9-Feb-2020

Summary

Official Symbol
MEIS3provided by HGNC
Official Full Name
Meis homeobox 3provided by HGNC
Primary source
HGNC:HGNC:29537
See related
Ensembl:ENSG00000105419
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRG2
Summary
This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells. [provided by RefSeq, Sep 2016]
Expression
Biased expression in endometrium (RPKM 15.5), brain (RPKM 9.1) and 10 other tissues See more
Orthologs

Genomic context

See MEIS3 in Genome Data Viewer
Location:
19q13.32
Exon count:
16
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (47403118..47422233, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47906375..47922785, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene complement component 5a receptor 2 Neighboring gene DExH-box helicase 34 Neighboring gene solute carrier family 8 member A2 Neighboring gene NAPA antisense RNA 1 Neighboring gene kaptin, actin binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp547H236

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 

General protein information

Preferred Names
homeobox protein Meis3
Names
Meis1, myeloid ecotropic viral integration site 1 homolog 3
meis1-related protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051644.1 RefSeqGene

    Range
    7707..24110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001009813.3NP_001009813.1  homeobox protein Meis3 isoform 2

    See identical proteins and their annotated locations for NP_001009813.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses alternate in-frame acceptor splice sites at two internal exon junctions compared to variant 1, which results in a shorter isoform (2) missing two internal protein segments compared to isoform 1.
    Source sequence(s)
    AL537583, BC069251, CF993984
    Consensus CDS
    CCDS46132.1
    UniProtKB/Swiss-Prot
    Q99687
    UniProtKB/TrEMBL
    A0A024R0S2
    Related
    ENSP00000388667.2, ENST00000441740.6
    Conserved Domains (2) summary
    pfam05920
    Location:263302
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96162
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  2. NM_001301059.2NP_001287988.1  homeobox protein Meis3 isoform 3

    See identical proteins and their annotated locations for NP_001287988.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AL537583, BC045741, BI522513, BM783223, CF993984
    Consensus CDS
    CCDS74406.1
    UniProtKB/Swiss-Prot
    Q99687
    UniProtKB/TrEMBL
    A0A024R0W2, Q49A38
    Related
    ENSP00000454073.1, ENST00000558555.6
    Conserved Domains (2) summary
    pfam05920
    Location:280319
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96179
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  3. NM_001346148.1NP_001333077.1  homeobox protein Meis3 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC073548
  4. NM_020160.3NP_064545.1  homeobox protein Meis3 isoform 1

    See identical proteins and their annotated locations for NP_064545.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL537583, BC025404, CF993984, DB545063
    Consensus CDS
    CCDS33064.1
    UniProtKB/Swiss-Prot
    Q99687
    Related
    ENSP00000453307.1, ENST00000561293.5
    Conserved Domains (2) summary
    pfam05920
    Location:329365
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96179
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    47403118..47422233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451615.1XP_024307383.1  homeobox protein Meis3 isoform X6

    Conserved Domains (2) summary
    pfam05920
    Location:326362
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:93176
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  2. XM_024451616.1XP_024307384.1  homeobox protein Meis3 isoform X7

    Related
    ENSP00000333552.4, ENST00000331559.9
    Conserved Domains (2) summary
    pfam05920
    Location:312348
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96162
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  3. XM_024451617.1XP_024307385.1  homeobox protein Meis3 isoform X8

    Conserved Domains (2) summary
    pfam05920
    Location:197233
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:147
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  4. XM_024451614.1XP_024307382.1  homeobox protein Meis3 isoform X5

    Conserved Domains (2) summary
    pfam05920
    Location:350386
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:184220
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  5. XM_024451613.1XP_024307381.1  homeobox protein Meis3 isoform X2

    Conserved Domains (2) summary
    pfam05920
    Location:400436
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:184250
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  6. XM_024451612.1XP_024307380.1  homeobox protein Meis3 isoform X1

    Conserved Domains (2) summary
    pfam05920
    Location:417453
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:184267
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  7. XM_011527136.3XP_011525438.1  homeobox protein Meis3 isoform X4

    Conserved Domains (2) summary
    pfam05920
    Location:351390
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:184250
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  8. XM_017027011.1XP_016882500.1  homeobox protein Meis3 isoform X3

    UniProtKB/TrEMBL
    H0YNA8
    Related
    ENSP00000453934.1, ENST00000561096.5
Support Center