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Meis2 Meis homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 17536, updated on 12-May-2024

Summary

Official Symbol
Meis2provided by MGI
Official Full Name
Meis homeobox 2provided by MGI
Primary source
MGI:MGI:108564
See related
Ensembl:ENSMUSG00000027210 AllianceGenome:MGI:108564
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mrg1; Stra10; A430109D20Rik
Summary
This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcriptional regulators and several members have been shown to be essential contributors to developmental programs. In mice, a knock-out of this gene leads to lethality at embryonic day 14, accompanied with hemorrhaging. Embryos lacking this gene show defects in tissues derived from the neural crest, suggesting a critical role of this gene during cranial and cardiac neural crest cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Expression
Broad expression in frontal lobe adult (RPKM 31.3), CNS E14 (RPKM 21.9) and 17 other tissues See more
Orthologs
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Genomic context

See Meis2 in Genome Data Viewer
Location:
2 E4- E5; 2 58.28 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (115691745..115897925, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (115861264..116067537, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CDAN1 interacting nuclease 1 Neighboring gene predicted gene, 52524 Neighboring gene predicted gene, 31590 Neighboring gene STARR-seq mESC enhancer starr_05429 Neighboring gene STARR-seq mESC enhancer starr_05430 Neighboring gene RIKEN cDNA G630016G05 gene Neighboring gene RIKEN cDNA 2810405F15 gene Neighboring gene STARR-seq mESC enhancer starr_05431 Neighboring gene predicted gene, 57693

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in embryonic pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in eye development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within eye development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of myeloid cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cardiac muscle myoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeobox protein Meis2
Names
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2
meis1-related protein 1
myeloid ecotropic viral integration site-related gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136072.2NP_001129544.1  homeobox protein Meis2 isoform 1

    See identical proteins and their annotated locations for NP_001129544.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' and 3' UTRs and has multiple differences in the coding region, compared to variant 9. The encoded isoform (1) is shorter and has distinct N- and C-termini compared to isoform 9.
    Source sequence(s)
    AK146633, AL929037
    Consensus CDS
    CCDS50666.1
    UniProtKB/TrEMBL
    Q3TY73, Q3UJ35
    Related
    ENSMUSP00000106533.3, ENSMUST00000110908.9
    Conserved Domains (2) summary
    pfam05920
    Location:294333
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:110194
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  2. NM_001159567.1NP_001153039.1  homeobox protein Meis2 isoform 3

    See identical proteins and their annotated locations for NP_001153039.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and has multiple differences in the coding region, compared to variant 9. The encoded isoform (3) is shorter and has distinct N- and C-termini compared to isoform 9.
    Source sequence(s)
    AK146633, AK158839, AL929037
    Consensus CDS
    CCDS50668.1
    UniProtKB/TrEMBL
    Q3TY73
    Related
    ENSMUSP00000106532.2, ENSMUST00000110907.8
    Conserved Domains (2) summary
    pfam05920
    Location:294333
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:110194
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  3. NM_001159568.1NP_001153040.1  homeobox protein Meis2 isoform 4

    See identical proteins and their annotated locations for NP_001153040.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, and has multiple differences in the coding region, compared to variant 9. The encoded isoform (4) is shorter and has a distinct N-terminus compared to isoform 9.
    Source sequence(s)
    AK146633, AL929037, CX568764
    Consensus CDS
    CCDS50667.1
    UniProtKB/Swiss-Prot
    O35676, O35677, P97367, P97403, P97404
    UniProtKB/TrEMBL
    Q3TY73
    Related
    ENSMUSP00000028639.7, ENSMUST00000028639.13
    Conserved Domains (2) summary
    pfam05920
    Location:294333
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:110194
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  4. NM_001159569.2NP_001153041.1  homeobox protein Meis2 isoform 5

    See identical proteins and their annotated locations for NP_001153041.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region and differs in the 3' UTR, compared to variant 9. The encoded isoform (5) is shorter and has a distinct C-terminus compared to isoform 9.
    Source sequence(s)
    AK146633, AK158839, AL929037, CJ143034
    Consensus CDS
    CCDS50665.1
    UniProtKB/TrEMBL
    B1AWK4, Q3TY73
    Related
    ENSMUSP00000106531.3, ENSMUST00000110906.9
    Conserved Domains (2) summary
    pfam05920
    Location:293332
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:109193
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  5. NM_001159570.2NP_001153042.1  homeobox protein Meis2 isoform 6

    See identical proteins and their annotated locations for NP_001153042.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences in the coding region and differs in the 3' UTR, compared to variant 9. The encoded isoform (6) is shorter and has a distinct C-terminus compared to isoform 9.
    Source sequence(s)
    AK146633, AK158839, AL929037, CJ143034
    Consensus CDS
    CCDS50664.1
    UniProtKB/TrEMBL
    Q3TY73, Q3TYM2
    Related
    ENSMUSP00000073898.7, ENSMUST00000074285.8
    Conserved Domains (2) summary
    pfam05920
    Location:293332
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:109193
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  6. NM_001346036.1NP_001332965.1  homeobox protein Meis2 isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) encodes the longest isoform (9).
    Source sequence(s)
    AK146633, AK158839, AL772135, AL929037, BB612458, BQ572308, CX568764
    UniProtKB/TrEMBL
    Q3TY73, Q3UJ35
  7. NM_001346038.1NP_001332967.1  homeobox protein Meis2 isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks an alternate exon in the coding region, compared to variant 9. The encoded isoform (10) is shorter than isoform 9.
    Source sequence(s)
    AK146633, AK158839, AL772135, AL929037, BB612458, CX568764
    UniProtKB/TrEMBL
    Q3TY73
    Conserved Domains (2) summary
    pfam05920
    Location:293332
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:109193
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  8. NM_001346041.1NP_001332970.1  homeobox protein Meis2 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) has multiple differences in the coding region, compared to variant 9. The encoded isoform (11) is shorter than isoform 9.
    Source sequence(s)
    AK146633, AK158839, AL772135, AL929037, BB612458, KM974644
    UniProtKB/TrEMBL
    Q3TY73
    Conserved Domains (2) summary
    pfam05920
    Location:293332
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:109193
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  9. NM_001346044.1NP_001332973.1  homeobox protein Meis2 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) has multiple differences in the coding region and differs in the 3' UTR, compared to variant 9. The encoded isoform (12) is shorter and has a distinct C-terminus, compared to isoform 9.
    Source sequence(s)
    AK146633, AK158839, AL772135, AL929037, BB612458, BQ572308
    UniProtKB/TrEMBL
    Q3TY73
  10. NM_001346045.1NP_001332974.1  homeobox protein Meis2 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' and 3' UTRs and has multiple differences in the coding region, compared to variant 9. The encoded isoform (7) is shorter and has distinct N- and C-termini compared to isoform 9.
    Source sequence(s)
    AK146633, AL772135, AL929037, BQ572308
    UniProtKB/TrEMBL
    Q3TY73
  11. NM_001346047.1NP_001332976.1  homeobox protein Meis2 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' and 3' UTRs and has multiple differences in the coding region, compared to variant 9. The encoded isoform (8) is shorter and has distinct N- and C-termini compared to isoform 9.
    Source sequence(s)
    AK012325, AK146633, AK158839, AL772135, AL929037, BY012436
    UniProtKB/TrEMBL
    Q3TY73
    Conserved Domains (2) summary
    pfam05920
    Location:313352
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:129213
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  12. NM_001346053.1NP_001332982.1  homeobox protein Meis2 isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' and 3' UTRs and has multiple differences in the coding region, compared to variant 9. The encoded isoform (13) is shorter and has distinct N- and C-termini compared to isoform 9. Variants 13 and 14 encode the same isoform (13).
    Source sequence(s)
    AK146633, AK158839, AL929037, BY290986
    UniProtKB/TrEMBL
    A0A0A7EPH8
  13. NM_001346055.1NP_001332984.1  homeobox protein Meis2 isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR, uses a downstream start codon, has multiple differences in the coding region and differs in the 3' UTR, compared to variant 9. The encoded isoform (13) is shorter and has distinct N- and C-termini compared to isoform 9. Variants 13 and 14 encode the same isoform (13).
    Source sequence(s)
    AK146633, AK158839, AL929037, BY290986, CJ143034
    UniProtKB/TrEMBL
    A0A0A7EPH8
  14. NM_001346056.1NP_001332985.1  homeobox protein Meis2 isoform 15

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) differs in the 5' and 3' UTRs and has multiple differences in the coding region, compared to variant 9. The encoded isoform (15) is shorter and has distinct N- and C-termini compared to isoform 9.
    Source sequence(s)
    AK146633, AL929037, BY290986
    UniProtKB/TrEMBL
    A0A0A7EPH8
    Conserved Domains (2) summary
    pfam05920
    Location:206245
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:22106
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  15. NM_010825.3NP_034955.1  homeobox protein Meis2 isoform 2

    See identical proteins and their annotated locations for NP_034955.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and has multiple differences in the coding region, compared to variant 9. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 9.
    Source sequence(s)
    AK146633, AL929037, KM974644
    Consensus CDS
    CCDS16568.1
    UniProtKB/TrEMBL
    Q3TY73, Q6GU28
    Related
    ENSMUSP00000099597.4, ENSMUST00000102538.11
    Conserved Domains (2) summary
    pfam05920
    Location:294333
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:110194
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    115691745..115897925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159069.1XP_036014962.1  homeobox protein Meis2 isoform X12

    Conserved Domains (2) summary
    pfam05920
    Location:148187
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:148
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  2. XM_036159067.1XP_036014960.1  homeobox protein Meis2 isoform X11

    Conserved Domains (2) summary
    pfam05920
    Location:148187
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:148
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  3. XM_030248227.2XP_030104087.1  homeobox protein Meis2 isoform X13

    Conserved Domains (2) summary
    pfam05920
    Location:148187
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:148
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  4. XM_036159066.1XP_036014959.1  homeobox protein Meis2 isoform X10

    Conserved Domains (2) summary
    pfam05920
    Location:211250
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:148
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  5. XM_030248221.2XP_030104081.1  homeobox protein Meis2 isoform X5

    Conserved Domains (2) summary
    pfam05920
    Location:313352
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:129213
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  6. XM_006498871.5XP_006498934.1  homeobox protein Meis2 isoform X9

    See identical proteins and their annotated locations for XP_006498934.1

    UniProtKB/TrEMBL
    Q3TY73
    Conserved Domains (2) summary
    pfam05920
    Location:313352
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:129213
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  7. XM_030248224.2XP_030104084.1  homeobox protein Meis2 isoform X9

    UniProtKB/TrEMBL
    Q3TY73
    Conserved Domains (2) summary
    pfam05920
    Location:313352
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:129213
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  8. XM_036159058.1XP_036014951.1  homeobox protein Meis2 isoform X4

    Conserved Domains (2) summary
    pfam05920
    Location:313352
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:129213
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  9. XM_036159055.1XP_036014948.1  homeobox protein Meis2 isoform X2

    Conserved Domains (2) summary
    pfam05920
    Location:376415
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:129213
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  10. XM_036159064.1XP_036014957.1  homeobox protein Meis2 isoform X7

    UniProtKB/TrEMBL
    Q3TY73
    Conserved Domains (2) summary
    pfam05920
    Location:376415
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:129213
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  11. XM_011239337.4XP_011237639.1  homeobox protein Meis2 isoform X1

    See identical proteins and their annotated locations for XP_011237639.1

    Conserved Domains (2) summary
    pfam05920
    Location:376415
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:129213
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  12. XM_036159061.1XP_036014954.1  homeobox protein Meis2 isoform X6

    UniProtKB/TrEMBL
    Q3TY73
    Conserved Domains (2) summary
    pfam05920
    Location:376415
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:129213
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  13. XM_036159065.1XP_036014958.1  homeobox protein Meis2 isoform X8

    UniProtKB/TrEMBL
    Q3TY73
    Conserved Domains (2) summary
    pfam05920
    Location:357396
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:110194
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  14. XM_006498864.5XP_006498927.1  homeobox protein Meis2 isoform X3

    Conserved Domains (2) summary
    pfam05920
    Location:357396
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:110194
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  15. XM_030248225.2XP_030104085.1  homeobox protein Meis2 isoform X11

    Conserved Domains (2) summary
    pfam05920
    Location:148187
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:148
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  16. XM_030248226.2XP_030104086.1  homeobox protein Meis2 isoform X12

    Conserved Domains (2) summary
    pfam05920
    Location:148187
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:148
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1