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MEIS2 Meis homeobox 2 [ Homo sapiens (human) ]

Gene ID: 4212, updated on 18-May-2021

Summary

Official Symbol
MEIS2provided by HGNC
Official Full Name
Meis homeobox 2provided by HGNC
Primary source
HGNC:HGNC:7001
See related
Ensembl:ENSG00000134138 MIM:601740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRG1; CPCMR; HsT18361
Summary
This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 12.8), prostate (RPKM 12.0) and 24 other tissues See more
Orthologs
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Genomic context

See MEIS2 in Genome Data Viewer
Location:
15q14
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (36889204..37101311, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (37181405..37393512, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene CDAN1 interacting nuclease 1 Neighboring gene casein kinase 1 alpha 1 pseudogene 1 Neighboring gene uncharacterized LOC145845 Neighboring gene VISTA enhancer hs181 Neighboring gene microRNA 8063 Neighboring gene VISTA enhancer hs572 Neighboring gene VISTA enhancer hs599

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Cleft palate, cardiac defects, and mental retardation
MedGen: C1832950 OMIM: 600987 GeneReviews: Not available
Compare labs
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
GeneReviews: Not available
Genome-wide association study and meta-analysis of intraocular pressure.
GeneReviews: Not available
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
GeneReviews: Not available

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2014-11-05)

ClinGen Genome Curation Page
Haploinsufficency

Some evidence for dosage pathogenicity (Last evaluated 2014-11-05)

ClinGen Genome Curation PagePubMed

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2820

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in embryonic pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in eye development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of myeloid cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
involved_in pancreas development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cardiac muscle myoblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to growth factor IEA
Inferred from Electronic Annotation
more info
 
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
homeobox protein Meis2
Names
Meis homolog 2
Meis1, myeloid ecotropic viral integration site 1 homolog 2
Meis1-related gene 1
TALE homeobox protein Meis2
meis1-related protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029108.1 RefSeqGene

    Range
    5001..215279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001220482.2NP_001207411.1  homeobox protein Meis2 isoform d

    See identical proteins and their annotated locations for NP_001207411.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (i) differs in the 5' UTR, lacks the coding exon containing the stop codon, and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant a. The resulting isoform (d) has a longer and distinct C-terminus and lacks an alternate in-frame segment compared to isoform a. Variants d and i both encode the same isoform (d).
    Source sequence(s)
    AC018563, AC078909, AK226072, AK300247, BC050431, BM679305
    Consensus CDS
    CCDS10045.1
    UniProtKB/Swiss-Prot
    O14770
    UniProtKB/TrEMBL
    A0A024R9L4, B7Z6F6
    Related
    ENSP00000341400.4, ENST00000338564.9
    Conserved Domains (2) summary
    pfam05920
    Location:294333
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:110194
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  2. NM_002399.4NP_002390.1  homeobox protein Meis2 isoform f

    See identical proteins and their annotated locations for NP_002390.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (f) differs in the 5' UTR and coding sequence compared to variant a. The resulting isoform (f) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AC018563, AC078909, AK300247, BC001516, BM679305
    Consensus CDS
    CCDS42014.1
    UniProtKB/Swiss-Prot
    O14770
    UniProtKB/TrEMBL
    B7Z6F6
    Related
    ENSP00000339549.5, ENST00000340545.9
    Conserved Domains (2) summary
    pfam05920
    Location:281320
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:97181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  3. NM_170674.5NP_733774.1  homeobox protein Meis2 isoform b

    See identical proteins and their annotated locations for NP_733774.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) uses an alternate in-frame splice junction at the 5' end of a coding exon compared to variant a. It encodes a shorter isoform (b) that is missing an internal segment compared to isoform a.
    Source sequence(s)
    AC018563, AC078909, AF179896, AK056216, BC050431, BM679305, DA689122
    Consensus CDS
    CCDS45218.1
    UniProtKB/Swiss-Prot
    O14770
    UniProtKB/TrEMBL
    B3KPD8
    Related
    ENSP00000453497.1, ENST00000559561.5
    Conserved Domains (2) summary
    pfam05920
    Location:294333
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:110194
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  4. NM_170675.5NP_733775.1  homeobox protein Meis2 isoform c

    See identical proteins and their annotated locations for NP_733775.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) lacks the exon containing the stop codon compared to variant a, that causes a frameshift. The resulting isoform (c) contains a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC018563, AC078909, AF179897, AK056216, BC050431, BM679305, DA689122
    Consensus CDS
    CCDS10044.1
    UniProtKB/Swiss-Prot
    O14770
    UniProtKB/TrEMBL
    B3KPD8
    Related
    ENSP00000453793.1, ENST00000561208.6
    Conserved Domains (3) summary
    pfam05920
    Location:294333
    Homeobox_KN; Homeobox KN domain
    pfam09770
    Location:335463
    PAT1; Topoisomerase II-associated protein PAT1
    pfam16493
    Location:110194
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  5. NM_170676.5NP_733776.1  homeobox protein Meis2 isoform d

    See identical proteins and their annotated locations for NP_733776.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) uses an alternate in-frame splice junction at the 5' end of a coding exon and lacks the exon containing the stop codon compared to variant a, that causes a frameshift. The resulting isoform (d) lacks an alternate internal segment and has a longer and distinct C-terminus compared to isoform a. Variants d and i both encode the same isoform (d).
    Source sequence(s)
    AC018563, AC078909, AF179898, AK056216, BC050431, BM679305, DA689122
    Consensus CDS
    CCDS10045.1
    UniProtKB/Swiss-Prot
    O14770
    UniProtKB/TrEMBL
    A0A024R9L4, B3KPD8
    Conserved Domains (2) summary
    pfam05920
    Location:294333
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:110194
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  6. NM_170677.5NP_733777.1  homeobox protein Meis2 isoform a

    See identical proteins and their annotated locations for NP_733777.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the longest transcript.
    Source sequence(s)
    AC018563, AC078909, AF178948, AK056216, BC050431, BM679305, DA689122
    Consensus CDS
    CCDS45217.1
    UniProtKB/Swiss-Prot
    O14770
    UniProtKB/TrEMBL
    B3KPD8
    Related
    ENSP00000404185.2, ENST00000424352.6
    Conserved Domains (2) summary
    pfam05920
    Location:294333
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:110194
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  7. NM_172315.3NP_758526.1  homeobox protein Meis2 isoform g

    See identical proteins and their annotated locations for NP_758526.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (g) differs in the 5' UTR and coding sequence compared to variant a. The resulting isoform (g) has a shorter N-terminus when compared to isoform a.
    Source sequence(s)
    AC018563, AC078909, AK056038, AK226072, BM679305, DA648763
    Consensus CDS
    CCDS45219.1
    UniProtKB/Swiss-Prot
    O14770
    Related
    ENSP00000453390.1, ENST00000559085.5
    Conserved Domains (2) summary
    pfam05920
    Location:281320
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:97181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  8. NM_172316.3NP_758527.1  homeobox protein Meis2 isoform h

    See identical proteins and their annotated locations for NP_758527.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (h) differs in the 5' UTR and coding sequence compared to isoform a. The resulting isoform (h) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AC018563, AC078909, AK056620, AK226072, BM679305
    Consensus CDS
    CCDS45220.1
    UniProtKB/Swiss-Prot
    O14770
    Related
    ENSP00000380745.2, ENST00000397620.6
    Conserved Domains (2) summary
    pfam05920
    Location:206245
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:22106
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RNA

  1. NR_051953.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) lacks an alternate coding exon and internal segment compared to variant a, that causes a frameshift. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is therefore not thought to be protein-coding.
    Source sequence(s)
    AC018563, AC078909, AF179899, AK056216, BC050431, BM679305, DA689122

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    36889204..37101311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449927.1XP_024305695.1  homeobox protein Meis2 isoform X3

    Conserved Domains (2) summary
    pfam05920
    Location:281320
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:97180
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  2. XM_024449925.1XP_024305693.1  homeobox protein Meis2 isoform X2

    Conserved Domains (3) summary
    pfam05920
    Location:281320
    Homeobox_KN; Homeobox KN domain
    pfam09770
    Location:322450
    PAT1; Topoisomerase II-associated protein PAT1
    pfam16493
    Location:97181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  3. XM_024449929.1XP_024305697.1  homeobox protein Meis2 isoform X7

    Conserved Domains (2) summary
    pfam05920
    Location:281320
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:97181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  4. XM_017022205.2XP_016877694.1  homeobox protein Meis2 isoform X9

    UniProtKB/Swiss-Prot
    O14770
    Related
    ENSP00000380749.3, ENST00000397624.7
    Conserved Domains (2) summary
    pfam05920
    Location:206245
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:22106
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  5. XM_006720526.3XP_006720589.1  homeobox protein Meis2 isoform X6

    See identical proteins and their annotated locations for XP_006720589.1

    Conserved Domains (3) summary
    pfam05920
    Location:206245
    Homeobox_KN; Homeobox KN domain
    pfam09770
    Location:247375
    PAT1; Topoisomerase II-associated protein PAT1
    pfam16493
    Location:22106
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  6. XM_006720527.3XP_006720590.1  homeobox protein Meis2 isoform X8

    See identical proteins and their annotated locations for XP_006720590.1

    Conserved Domains (2) summary
    pfam05920
    Location:148187
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:147
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  7. XM_006720529.3XP_006720592.1  homeobox protein Meis2 isoform X10

    See identical proteins and their annotated locations for XP_006720592.1

    UniProtKB/TrEMBL
    B3KP81
    Related
    ENSP00000475899.1, ENST00000607277.5
    Conserved Domains (2) summary
    pfam05920
    Location:148187
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:148
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  8. XM_006720525.1XP_006720588.1  homeobox protein Meis2 isoform X5

    See identical proteins and their annotated locations for XP_006720588.1

    Conserved Domains (2) summary
    pfam05920
    Location:293332
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:109193
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  9. XM_006720523.1XP_006720586.1  homeobox protein Meis2 isoform X1

    See identical proteins and their annotated locations for XP_006720586.1

    Conserved Domains (3) summary
    pfam05920
    Location:293332
    Homeobox_KN; Homeobox KN domain
    pfam09770
    Location:334462
    PAT1; Topoisomerase II-associated protein PAT1
    pfam16493
    Location:109193
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  10. XM_006720524.1XP_006720587.1  homeobox protein Meis2 isoform X4

    See identical proteins and their annotated locations for XP_006720587.1

    Conserved Domains (2) summary
    pfam05920
    Location:293332
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:109193
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  11. XM_024449928.1XP_024305696.1  homeobox protein Meis2 isoform X6

    Conserved Domains (3) summary
    pfam05920
    Location:206245
    Homeobox_KN; Homeobox KN domain
    pfam09770
    Location:247375
    PAT1; Topoisomerase II-associated protein PAT1
    pfam16493
    Location:22106
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  12. XM_024449926.1XP_024305694.1  homeobox protein Meis2 isoform X2

    Conserved Domains (3) summary
    pfam05920
    Location:281320
    Homeobox_KN; Homeobox KN domain
    pfam09770
    Location:322450
    PAT1; Topoisomerase II-associated protein PAT1
    pfam16493
    Location:97181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  13. XM_011521591.2XP_011519893.1  homeobox protein Meis2 isoform X8

    See identical proteins and their annotated locations for XP_011519893.1

    Conserved Domains (2) summary
    pfam05920
    Location:148187
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:147
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RNA

  1. XR_002957641.1 RNA Sequence

  2. XR_002957640.1 RNA Sequence

  3. XR_001751290.2 RNA Sequence

    Related
    ENST00000314177.12

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020149.2: Suppressed sequence

    Description
    NM_020149.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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