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ulp-2 Ubiquitin-like protease 2;Ubiquitin-like protease family profile domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173859, updated on 18-Sep-2024

Summary

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Official Symbol
ulp-2
Official Full Name
Ubiquitin-like protease 2;Ubiquitin-like protease family profile domain-containing protein
Primary source
WormBase:WBGene00006737
Locus tag
CELE_Y38A8.3
See related
AllianceGenome:WB:WBGene00006737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable SUMO-specific isopeptidase activity. Involved in adherens junction maintenance; protein desumoylation; and regulation of cell-cell adhesion involved in gastrulation. Located in cytosol and nucleus. Is expressed in hypodermis and neuroblasts. Orthologous to human SENP6 (SUMO specific peptidase 6) and SENP7 (SUMO specific peptidase 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
15
Sequence:
Chromosome: II; NC_003280.10 (4955450..4959876, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Zygote defective protein 12 Neighboring gene Nudix hydrolase 3 Neighboring gene Proteasome subunit beta type-3 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ULP-2 SUMO Protease Regulates E-Cadherin Recruitment to Adherens Junctions. Tsur A, et al. Dev Cell, 2015 Oct 12. PMID 26412237
  2. Erratum: Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans. Pelisch F, et al. Nat Commun, 2015 Feb 12. PMID 25672768, Free PMC Article
  3. Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans. Pelisch F, et al. Nat Commun, 2014 Dec 5. PMID 25475837, Free PMC Article
  4. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ULP-2 SUMO protease regulates UPR[mt] and mitochondrial homeostasis in Caenorhabditis elegans.
    Title: ULP-2 SUMO protease regulates UPR(mt) and mitochondrial homeostasis in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables deSUMOylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deSUMOylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adherens junction maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein desumoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein desumoylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell-cell adhesion involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ubiquitin-like protease 2;Ubiquitin-like protease family profile domain-containing protein
NP_001305240.1
  • Confirmed by transcript evidence
NP_001305241.1
  • Confirmed by transcript evidence
NP_494914.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    4955450..4959876 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001318311.3 → NP_001305240.1  Ubiquitin-like protease family profile domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0S4XR45
    Conserved Domains (1) summary
    pfam02902
    Location:371 → 609
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  2. NM_062513.6 → NP_494914.1  Ubiquitin-like protease 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494914.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23238
    Conserved Domains (1) summary
    pfam02902
    Location:553 → 771
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  3. NM_001318312.3 → NP_001305241.1  Ubiquitin-like protease family profile domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0S4XRS7
    Conserved Domains (1) summary
    pfam02902
    Location:1 → 232
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23238.2

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