car-1 Protein LSM14 homolog car-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: car-1
Official Full Name: Protein LSM14 homolog car-1
Primary source: WormBase:WBGene00012484
Locus tag: CELE_Y18D10A.17
See related: AllianceGenome:WB:WBGene00012484
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II core promoter sequence-specific DNA binding activity. Involved in positive regulation of gene expression. Located in cytoplasmic ribonucleoprotein granule; endoplasmic reticulum; and microtubule cytoskeleton. Part of messenger ribonucleoprotein complex. Is expressed in germ line; gonad; neurons; and somatic cell. Orthologous to human LSM14B (LSM family member 14B) and LSM14A (LSM14A mRNA processing body assembly factor). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See car-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (12904470..12906040)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural and biochemical insights into the recognition of RNA helicase CGH-1 by CAR-1 in C. elegans.
Title: Structural and biochemical insights into the recognition of RNA helicase CGH-1 by CAR-1 in C. elegans.
The mRNA Decay Factor CAR-1/LSM14 Regulates Axon Regeneration via Mitochondrial Calcium Dynamics.
Title: The mRNA Decay Factor CAR-1/LSM14 Regulates Axon Regeneration via Mitochondrial Calcium Dynamics.
These results indicate that both HMG-12 and CAR-1 play important roles in embryonic expression of cdc-48.1.
Title: Involvement of HMG-12 and CAR-1 in the cdc-48.1 expression of Caenorhabditis elegans.
The CAR-1 protein functions with CGH-1 to regulate a specific set of maternally loaded RNAs that is required for anaphase spindle structure and cytokinesis.
Title: A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans.
CAR-1, a protein likely to be associated with RNA metabolism, plays an essential role in the late stage of cytokinesis, suggesting a novel link between RNA, membrane trafficking and cytokinesis in the C. elegans embryo
Title: CAR-1, a protein that localizes with the mRNA decapping component DCAP-1, is required for cytokinesis and ER organization in Caenorhabditis elegans embryos.
Regulation of physiological germ cell apoptosis is specifically influenced by certain functions of the CGH-1/CAR-1 RNA-protein complex.
Title: A conserved RNA-protein complex component involved in physiological germline apoptosis regulation in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y18D10A.17 (e-PCR)
- UniSTS:317293

Y18D10A.16 (e-PCR)
- UniSTS:317618

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in P-body assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress granule assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in pericentriolar material	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
located_in ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein LSM14 homolog car-1

NP_493254.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

12904470..12906040

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060853.7 → NP_493254.1 Protein LSM14 homolog car-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493254.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XW17

Conserved Domains (3) summary

cd01736
Location:5 → 77

LSm14_N; Like-Sm protein 14, N-terminal domain

pfam05091
Location:114 → 241

eIF-3_zeta; Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)

pfam09532
Location:185 → 268

FDF; FDF domain